2011
The microRNA regulation of stem cells
Huang XA, Lin H. The microRNA regulation of stem cells. Wiley Interdisciplinary Reviews Membrane Transport And Signalling 2011, 1: 83-95. PMID: 23024929, PMCID: PMC3459065, DOI: 10.1002/wdev.5.Peer-Reviewed Original ResearchStem cellsMore mRNA targetsAdult tissue stem cellsDistinct expression profilesEmbryonic stem cellsTissue stem cellsMiRNA pathwayNegative feedback loopGene regulationMicroRNA regulationMRNA targetsTranscription factorsGene expressionRegulatory mechanismsEpigenetic factorsExpression profilesBiological processesDifferent miRNAsConcerted controlRegulatory roleIPS cellsMiRNAsSuch regulationRegulationCells
2009
MicroRNAs: key regulators of stem cells
Gangaraju VK, Lin H. MicroRNAs: key regulators of stem cells. Nature Reviews Molecular Cell Biology 2009, 10: 116-125. PMID: 19165214, PMCID: PMC4118578, DOI: 10.1038/nrm2621.Peer-Reviewed Original ResearchConceptsPIWI-interacting RNAsAdult tissue stem cellsStem cell processesTissue stem cellsSmall RNAsStem cellsCell processesNext-generation sequencing technologiesKey protein factorsLong non-coding RNAsNon-coding RNAsNumber of miRNAsGeneration sequencing technologyTranscriptional machineryNew miRNAsAsymmetric divisionDaughter cellsTarget mRNAsProtein factorsMaster regulatorSequencing technologiesKey regulatorUntranslated regionDifferentiation pathwayMiRNAs
2008
Piecing Together the Mosaic of Early Mammalian Development through MicroRNAs*
Blakaj A, Lin H. Piecing Together the Mosaic of Early Mammalian Development through MicroRNAs*. Journal Of Biological Chemistry 2008, 283: 9505-9508. PMID: 18272516, PMCID: PMC2442291, DOI: 10.1074/jbc.r800002200.Peer-Reviewed Original ResearchConceptsRole of miRNAsES cellsEarly mammalian developmentMammalian ES cellsDozens of miRNAsRNase III enzymeCluster of miRNAsES cell differentiationEmbryonic stem cellsRNA biogenesisMammalian embryogenesisMammalian developmentLineage specificationMicroRNA pathwayMiR-290MiRNA biogenesisEmbryonic developmentNuclear proteinsCell differentiationMiRNAsStem cellsBiogenesisEarly developmentCellsCrucial role