Nathaniel Bachtel
About
Research
Publications
Featured Publications
Immune sensing of food allergens promotes avoidance behaviour
Florsheim E, Bachtel N, Cullen J, Lima B, Godazgar M, Carvalho F, Chatain C, Zimmer M, Zhang C, Gautier G, Launay P, Wang A, Dietrich M, Medzhitov R. Immune sensing of food allergens promotes avoidance behaviour. Nature 2023, 620: 643-650. PMID: 37437602, PMCID: PMC10432274, DOI: 10.1038/s41586-023-06362-4.Peer-Reviewed Original ResearchConceptsMast cellsImmune systemBALB/c miceAllergen-specific IgEDifferentiation factor 15Behavioral modificationAllergen avoidanceAllergic sensitizationAllergic inflammationFood allergyTractus solitariusC miceCysteinyl leukotrienesParabrachial nucleusAllergen ingestionE antibodiesCentral amygdalaFactor 15Mouse modelFood allergensBrain areasImmune sensingAvoidance behaviorAversive stimuliGenetic backgroundAdverse Food Reactions: Physiological and Ecological Perspectives
Korn L, Kutyavin V, Bachtel N, Medzhitov R. Adverse Food Reactions: Physiological and Ecological Perspectives. Annual Review Of Nutrition 2024, 44: 155-178. PMID: 38724028, PMCID: PMC12372117, DOI: 10.1146/annurev-nutr-061021-022909.Peer-Reviewed Original ResearchIntestinal mast cell–derived leukotrienes mediate the anaphylactic response to ingested antigens
Bachtel N, Cullen J, Liu M, Erickson S, Kutyavin V, El-Naccache D, Florsheim E, Lim J, Sullivan Z, Imaeda R, Hudak A, Zhang C, Medzhitov R. Intestinal mast cell–derived leukotrienes mediate the anaphylactic response to ingested antigens. Science 2025, 389: eadp0246. PMID: 40773543, DOI: 10.1126/science.adp0246.Peer-Reviewed Original ResearchConceptsLife-threatening complicationsIntestinal mast cellsMast cellsIntravenous injectionAntigen-induced responsesFood allergen exposureLeukotriene synthesisCysteinyl leukotriene synthesisOral anaphylaxisTissue mast cellsMucosal exposureConnective tissue mast cellsIntestine of miceEffector functionsAnaphylactic responseReceptor 1Allergen exposureArachidonate 5-lipoxygenaseAnaphylaxisMiceLeukotrieneHeterogeneous populationCellsInjectionAntagonist
2025
The five senses of immunity
Nixon D, Bachtel N, Hupert N, Eleftherianos I. The five senses of immunity. Trends In Immunology 2025, 46: 361-363. PMID: 40251093, PMCID: PMC12172028, DOI: 10.1016/j.it.2025.03.005.Peer-Reviewed Original Research
2024
A model of proximate protection against pathogenic infection through shared immunity
Nixon D, Kyza-Karavioti M, Mallick S, Daley L, Hupert N, Bachtel N, Eleftherianos I. A model of proximate protection against pathogenic infection through shared immunity. MBio 2024, 15: e03046-24. PMID: 39526781, PMCID: PMC11633142, DOI: 10.1128/mbio.03046-24.Peer-Reviewed Original ResearchDrosophila melanogasterHost immune defenseTransforming biomedical researchMicrobial signalsPathogen infectionPathogen challengeAdult fliesImmunological primingInsect pathogensImmune defenseInfected hostsInnate immune primingImmune primingHostPathogensInfluence immunityBiomedical researchHealthy individualsFliesPrimed hostsProtective effectLethal doseImmunityBacteriaSpecific chemicals
2019
Introduction
Bachtel N, Israni-Winger K. Introduction. Axon 2019, 93: 227-228. PMCID: PMC7309659, DOI: 10.30687/axon/2532-6848/2019/06/000.Peer-Reviewed Original ResearchThe Psychiatric Risk Gene NT5C2 Regulates Adenosine Monophosphate-Activated Protein Kinase Signaling and Protein Translation in Human Neural Progenitor Cells
Duarte RRR, Bachtel ND, Côtel MC, Lee SH, Selvackadunco S, Watson IA, Hovsepian GA, Troakes C, Breen GD, Nixon DF, Murray RM, Bray NJ, Eleftherianos I, Vernon AC, Powell TR, Srivastava DP. The Psychiatric Risk Gene NT5C2 Regulates Adenosine Monophosphate-Activated Protein Kinase Signaling and Protein Translation in Human Neural Progenitor Cells. Biological Psychiatry 2019, 86: 120-130. PMID: 31097295, PMCID: PMC6614717, DOI: 10.1016/j.biopsych.2019.03.977.Peer-Reviewed Original ResearchConceptsHuman neural progenitor cellsProtein translationNeural progenitor cellsMotility behaviorAvailable expression dataRibosomal protein S6Protein Kinase SignalingRegulation of AMPKProgenitor cellsNutrient sensing mechanismsProtein kinase alphaQuantitative polymerase chain reactionPsychiatric risk allelesDrosophila melanogasterTranscriptional changesKinase signalingProtein S6Transcriptomic profilingRNA interferenceNeural stem cellsExpression changesKinase alphaUnknown roleExpression dataHuman dorsolateral prefrontal cortex22THE PSYCHIATRIC RISK GENE NT5C2 REGULATES PROTEIN TRANSLATION IN HUMAN NEURAL PROGENITOR CELLS, AND IS INVOLVED IN LOCOMOTOR BEHAVIOUR IN DROSOPHILA MELANOGASTER
Duarte R, Bachtel N, Eleftherianos I, Nixon D, Murray R, Bray N, Powell T, Srivastava D. 22THE PSYCHIATRIC RISK GENE NT5C2 REGULATES PROTEIN TRANSLATION IN HUMAN NEURAL PROGENITOR CELLS, AND IS INVOLVED IN LOCOMOTOR BEHAVIOUR IN DROSOPHILA MELANOGASTER. European Neuropsychopharmacology 2019, 29: s1078. DOI: 10.1016/j.euroneuro.2018.08.029.Peer-Reviewed Original Research
2018
Short Communication: Expression of Host Restriction Factors by Memory CD4+ T Cells Differs Between Healthy Donors and HIV-1-Infected Individuals with Effective Antiretroviral Therapy
Bachtel ND, Beckerle GA, Mota TM, de Mulder Rougvie M, Raposo RAS, Jones RB, Nixon DF, Apps R. Short Communication: Expression of Host Restriction Factors by Memory CD4+ T Cells Differs Between Healthy Donors and HIV-1-Infected Individuals with Effective Antiretroviral Therapy. AIDS Research And Human Retroviruses 2018, 35: 108-111. PMID: 30198299, PMCID: PMC6343196, DOI: 10.1089/aid.2018.0162.Peer-Reviewed Original ResearchConceptsHIV-1-infected individualsHost restriction factorsRestriction factor expressionEffective antiretroviral therapyAntiretroviral therapyUninfected individualsMemory CD4Viral reservoirRestriction factorsT cellsChronic HIV-1 infectionHIV-1 gag DNAHIV-1 reservoir sizeFactor expressionMemory T cell compartmentQuantitative viral outgrowth assaysART-suppressed individualsSuppressive antiretroviral therapyViral outgrowth assaysHIV-1 infectionT cell compartmentDroplet digital polymerase chain reactionGag DNAViral loadImmune activationPublisher Correction: Evidence that CD32a does not mark the HIV-1 latent reservoir
Osuna C, Lim S, Kublin J, Apps R, Chen E, Mota T, Huang S, Ren Y, Bachtel N, Tsibris A, Ackerman M, Jones R, Nixon D, Whitney J. Publisher Correction: Evidence that CD32a does not mark the HIV-1 latent reservoir. Nature 2018, 563: e33-e33. PMID: 30315222, DOI: 10.1038/s41586-018-0611-3.Peer-Reviewed Original Research