Michael Vetick
About
Research
Publications
2022
The expression of essential selenoproteins during development requires SECIS-binding protein 2–like
Kiledjian N, Shah R, Vetick M, Copeland P. The expression of essential selenoproteins during development requires SECIS-binding protein 2–like. Life Science Alliance 2022, 5: e202101291. PMID: 35210313, PMCID: PMC8881744, DOI: 10.26508/lsa.202101291.Peer-Reviewed Original ResearchConceptsSECIS-binding protein 2Sec insertion sequenceSelenoprotein synthesisProtein 2Amino acid selenocysteineFrame UGA codonDays post fertilizationEssential selenoproteinsCRISPR mutationsSec incorporationUGA codonSelenoprotein mRNAsPost fertilizationRNA structureSe labelingSelenoproteinsFull complementInsertion sequenceEmbryosCodonGenesSBP2Oxidative stressDietary requirementsRelative roles
2019
Processive Recoding and Metazoan Evolution of Selenoprotein P: Up to 132 UGAs in Molluscs
Baclaocos J, Santesmasses D, Mariotti M, Bierła K, Vetick MB, Lynch S, McAllen R, Mackrill JJ, Loughran G, Guigó R, Szpunar J, Copeland PR, Gladyshev VN, Atkins JF. Processive Recoding and Metazoan Evolution of Selenoprotein P: Up to 132 UGAs in Molluscs. Journal Of Molecular Biology 2019, 431: 4381-4407. PMID: 31442478, PMCID: PMC6885538, DOI: 10.1016/j.jmb.2019.08.007.Peer-Reviewed Original ResearchConceptsSELENOP geneEvolution of selenoproteinsPacific oyster Magallana gigasC-terminal domainN-terminal domainOyster Magallana gigasGene evolutionRibosome profilingMammalian counterpartsRibosome progressionMagallana gigasCertain insectsDynamic evolutionary processInitiation codonSECIS elementsGenetic elementsRNA structureCommon spiderEvolutionary processesSelenoprotein expressionSELENOP mRNAUGAAquatic organismsBivalve molluscsSelenocysteine
2018
Processive incorporation of multiple selenocysteine residues is driven by a novel feature of the selenocysteine insertion sequence
Shetty SP, Sturts R, Vetick M, Copeland PR. Processive incorporation of multiple selenocysteine residues is driven by a novel feature of the selenocysteine insertion sequence. Journal Of Biological Chemistry 2018, 293: 19377-19386. PMID: 30323062, PMCID: PMC6302164, DOI: 10.1074/jbc.ra118.005211.Peer-Reviewed Original Research