Katherine Gross
she/her/hers
About
Research
Publications
2026
Divalent siRNA for prion disease
Gentile J, Corridon T, Serack F, Echeverria D, Kennedy Z, Gallant-Behm C, Hassler M, Kinberger G, Kelemen M, Kamath N, Lian Y, Gross K, Miller R, DeSouza-Lenz K, Howard M, Guzman K, Chan N, Laversenne V, Curtis D, Fettes K, Lemaitre M, Jackson A, Yamada K, Alterman J, Coffey A, Minikel E, Khvorova A, Vallabh S. Divalent siRNA for prion disease. Nucleic Acids Research 2026, 54: gkag287. PMID: 42033217, PMCID: PMC13107126, DOI: 10.1093/nar/gkag287.Peer-Reviewed Original ResearchRNAi-mediated p38δ silencing mitigates anthracycline cardiotoxicity in female mice
Trampel K, Gross K, O’Reilly D, Melisova A, Salman B, Green S, George S, Khvorova A, Efimov I, Efimova T. RNAi-mediated p38δ silencing mitigates anthracycline cardiotoxicity in female mice. AJP Heart And Circulatory Physiology 2026, 330: h1522-h1539. PMID: 41874387, PMCID: PMC13390149, DOI: 10.1152/ajpheart.00944.2025.Peer-Reviewed Original ResearchThe Approval of Redemplo for Familial Chylomicronemia Syndrome and the Many Flavors of GalNAc-Oligonucleotides
Alterman J, Gross K, Khvorova A. The Approval of Redemplo for Familial Chylomicronemia Syndrome and the Many Flavors of GalNAc-Oligonucleotides. Nucleic Acid Therapeutics 2026, 36: 129-134. PMID: 41877501, DOI: 10.1177/21593337261435980.Peer-Reviewed Original ResearchAn siRNA targeting S6k1 identifies photoreceptor phospholipid metabolism as a contributor to lipid buildup in age-related macular degeneration
Cheng S, Giguere D, Kim S, Seddon J, Caiazzi J, Gross K, McHugh N, Echeverria D, Alterman J, Gray-Edwards H, Benatti H, Renner L, Woolard H, Stoddard J, McGill T, Neuringer M, Brush R, Agbaga M, Khvorova A, Punzo C. An siRNA targeting S6k1 identifies photoreceptor phospholipid metabolism as a contributor to lipid buildup in age-related macular degeneration. Molecular Therapy - Nucleic Acids 2026, 37: 102878. PMID: 41858838, PMCID: PMC12996783, DOI: 10.1016/j.omtn.2026.102878.Peer-Reviewed Original ResearchIntradermal delivery of lipophilic siRNAs enables prolonged skin retention and sustained gene silencing in a porcine model
Fakih H, Zain UI Abideen M, Rachid M, Gross K, Ormsby T, Ross V, Gagnon R, Dahlke C, Furgal R, Lochmann C, Summers A, Sleiman H, Fürst S, Jackson S, Gordilho J, Bouix-Peter C, Portal T, Tang Q, Harris J, Khvorova A, Blanchard C, Alterman J. Intradermal delivery of lipophilic siRNAs enables prolonged skin retention and sustained gene silencing in a porcine model. Nature Communications 2026, 17: 2292. PMID: 41634015, PMCID: PMC12976281, DOI: 10.1038/s41467-026-68993-1.Peer-Reviewed Original ResearchPresence of phosphodiester backbone, but not nucleobases, in the guide’s 3′ terminal region is necessary for RISC loading and target cleavage in vitro and in vivo
O’Reilly D, Furgal R, Ross V, Luu E, Gross K, Hariharan V, Summers A, Cooper D, Allen S, Dahlke C, Rachid M, Chan I, Fakih H, Alterman J, Echeverria D, Watts J, Khvorova A. Presence of phosphodiester backbone, but not nucleobases, in the guide’s 3′ terminal region is necessary for RISC loading and target cleavage in vitro and in vivo. Nucleic Acids Research 2026, 54: gkaf1438. PMID: 41521659, PMCID: PMC12784967, DOI: 10.1093/nar/gkaf1438.Peer-Reviewed Original Research
2025
Potent and durable gene modulation in heart and muscle with chemically defined lipophilic siRNAs
Fakih H, Lochmann C, Gagnon R, Summers A, Caiazzi J, Buchwald J, Tang Q, Maru B, Hildebrand S, Abideen M, Furgal R, Gross K, Yang Y, Cooper D, Monopoli K, Echeverria D, Shim J, Yamada K, Alterman J, Khvorova A. Potent and durable gene modulation in heart and muscle with chemically defined lipophilic siRNAs. Nucleic Acids Research 2025, 53: gkaf1374. PMID: 41432033, PMCID: PMC12723224, DOI: 10.1093/nar/gkaf1374.Peer-Reviewed Original ResearchAlbumin-binding dendritic siRNA improves delivery and efficacy to solid tumors in a melanoma model
Fakih H, Tang Q, Summers A, Gross K, Rachid M, Okamura K, Martinez N, Sleiman H, Harris J, Khvorova A. Albumin-binding dendritic siRNA improves delivery and efficacy to solid tumors in a melanoma model. Molecular Therapy - Nucleic Acids 2025, 36: 102579. PMID: 40606645, PMCID: PMC12213268, DOI: 10.1016/j.omtn.2025.102579.Peer-Reviewed Original ResearchA Therapeutic Small-Interfering RNA Potentiates Janus Kinase 1 Modulation for the Treatment of Dog Inflammatory Diseases
Tang Q, Fakih H, Gross K, Winter S, Bramato B, Yıldız-Altay U, Chang B, Echeverria D, Jackson S, McHugh N, Srnka A, Alterman J, Almela R, Kudej R, London C, Richmond J, Harris J, Khvorova A. A Therapeutic Small-Interfering RNA Potentiates Janus Kinase 1 Modulation for the Treatment of Dog Inflammatory Diseases. ACS Pharmacology & Translational Science 2025, 8: 1526-1535. PMID: 40534660, PMCID: PMC12171875, DOI: 10.1021/acsptsci.4c00594.Peer-Reviewed Original Research
2024
Multispecies-targeting siRNAs for the modulation of JAK1 in the skin
Tang Q, Gross K, Fakih H, Jackson S, Zain U I Abideen M, Monopoli K, Blanchard C, Bouix-Peter C, Portal T, Harris J, Khvorova A, Alterman J. Multispecies-targeting siRNAs for the modulation of JAK1 in the skin. Molecular Therapy - Nucleic Acids 2024, 35: 102117. PMID: 38304729, PMCID: PMC10831156, DOI: 10.1016/j.omtn.2024.102117.Peer-Reviewed Original Research