Josh Saskin
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Featured Publications
OR7A10 GPCR engineering boosts CAR-NK therapy against solid tumours
Yang L, Renauer PA, Tang K, Saskin J, Zhou L, Zou C, Lee SH, Fox M, Johnson-Noya S, Weiss B, Deng S, Fang P, Chen B, Sferruzza G, Fooladi S, Zhao K, Park D, Zhang F, Tu J, Chen J, Moliterno J, Gunel M, Peng L, Chen S. OR7A10 GPCR engineering boosts CAR-NK therapy against solid tumours. Nature 2026 DOI: 10.1038/s41586-026-10149-8.Peer-Reviewed Original ResearchThis study investigates engineering CAR-NK cells with OR7A10 to improve solid tumor treatment, showing enhanced tumor targeting, persistence, and survival in multiple cancer models.
2025
Hypothalamic opsin 3 suppresses MC4R signaling and potentiates Kir7.1 to promote food consumption.
Haddad HK, Mercado-Reyes JI, Mustafá ER, D'Souza SP, Chung CS, Nestor RRM, Olinski LE, Martinez Damonte V, Saskin J, Vemaraju S, Raingo J, Kauer JA, Lang RA, Oancea E. Hypothalamic opsin 3 suppresses MC4R signaling and potentiates Kir7.1 to promote food consumption. Proc Natl Acad Sci U S A 2025, 122: e2403891122. PMID: 39951488, DOI: 10.1073/pnas.2403891122.Peer-Reviewed Original Research
2024
Integrative functional genomic analyses identify genetic variants influencing skin pigmentation in Africans
Feng Y, Xie N, Inoue F, Fan S, Saskin J, Zhang C, Zhang F, Hansen MEB, Nyambo T, Mpoloka SW, Mokone GG, Fokunang C, Belay G, Njamnshi AK, Marks MS, Oancea E, Ahituv N, Tishkoff SA. Integrative functional genomic analyses identify genetic variants influencing skin pigmentation in Africans. Nat Genet 2024, 56: 258-272. PMID: 38200130, DOI: 10.1038/s41588-023-01626-1.Peer-Reviewed Original Research
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