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Josh Saskin

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About

Biography

Josh is a third-year MD-PhD student from Newtown, PA. He is currently a student in the lab of Sidi Chen, where he his graduate work lies within the intersection of cancer immunology, genetic engineering, and systems biology.

Josh completed his undergraduate education at Brown University, where he earned degrees in Chemistry and Biomedical Engineering with honors. At Brown, Josh’s research dissected GPCR-mediated signaling pathways implicated in melanoma progression. He also contributed to a thorough functional characterization of regulatory SNPs that yields insight into the evolutionary mechanisms of human skin color diversity. At Yale, Josh hopes to leverage his background in cell biology and functional genomics to explore how gene editing and high throughput screening can be used to identify therapies for hematologic and solid malignancies.

Outside of science and medicine, Josh enjoys pottery, cooking, and walking dogs around New Haven.

Last Updated on June 27, 2025.

Education & Training

ScB
Brown University, Chemistry (2023)
ScB
Brown University, Biomedical Engineering (2023)

Research

Publications

Featured Publications

  • OR7A10 GPCR engineering boosts CAR-NK therapy against solid tumours
    Yang L, Renauer PA, Tang K, Saskin J, Zhou L, Zou C, Lee SH, Fox M, Johnson-Noya S, Weiss B, Deng S, Fang P, Chen B, Sferruzza G, Fooladi S, Zhao K, Park D, Zhang F, Tu J, Chen J, Moliterno J, Gunel M, Peng L, Chen S. OR7A10 GPCR engineering boosts CAR-NK therapy against solid tumours. Nature 2026 DOI: 10.1038/s41586-026-10149-8.
    Peer-Reviewed Original Research
    This study investigates engineering CAR-NK cells with OR7A10 to improve solid tumor treatment, showing enhanced tumor targeting, persistence, and survival in multiple cancer models.

2025

2024

Academic Achievements & Community Involvement

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