Performance of Polygenic Risk Scores for Primary Open-Angle Glaucoma in Populations of African Descent
Chang-Wolf J, Kinzy T, Driessen S, Cruz L, Iyengar S, Peachey N, Aung T, Khor C, Williams S, Ramsay M, Olawoye O, Ashaye A, Klaver C, Hauser M, Thiadens A, Cooke Bailey J, Bonnemaijer P, Sanywia A, Cook C, Hassan H, Kanyaro N, Ntomoka C, Allingham R, van der Heide C, Taylor K, Rotter J, Wang S, ABDULLAHI S, Abu-Amero K, Anderson M, Akafo S, ALHASSAN M, Asimadu I, Ayyagari R, BAKAYOKO S, BIANGOUP NYAMSI P, Bowden D, Bromley W, Budenz D, Carmichael T, Challa P, Chen Y, Chuka-Okosa C, Costa V, Cruz D, DuBiner H, Ervin J, Feldman R, Flamme-Wiese M, Gaasterland D, Garnai S, Girkin C, GUIROU N, Guo X, Haines J, Hammond C, Herndon L, Hoffmann T, Hulette C, Hydara A, Igo Jr. R, Jorgenson E, KABWE J, KILANGALANGA N, Kizor-Akaraiwe N, Kuchtey R, LAMARI H, Li Z, Liebmann J, Liu Y, Loos R, Melo M, Moroi S, Msosa J, Mullins R, Nadkarni G, NAPO A, Ng M, Nunes H, Obeng-Nyarkoh E, Okeke A, Okeke S, OLANIYI O, Oliveira M, Pasquale L, Perez-Grossmann R, Pericak-Vance M, Qin X, RESNIKOFF S, Richards J, Schimiti R, Sim K, Sponsel W, Svidnicki P, Uche N, van Duijn C, Vasconcellos J, Wiggs J, Zangwill L, Risch N, Milea D, Weinreb R, Ashley-Koch A, Fingert J, Aslan M, Antonelli M, de Asis M, Bauer M, Brophy M, Concato J, Cunningham F, Freedman R, Gaziano M, Gleason T, Harvey P, Huang G, Kelsoe J, Kosten T, Lehner T, Lohr J, Marder S, Miller P, O Leary T, Patterson T, Peduzzi P, Przygodski R, Siever L, Sklar P, Strakowski S, Zhao H, Fanous A, Farwell W, Malhorta A, Mane S, Palacios P, Bigdeli T, Corsey M, Zaluda L, Johnson J, Sueiro M, Cavaliere D, Jeanpaul V, Maffucci A, Mancini L, Deen J, Muldoon G, Whitbourne S, Canive J, Adamson L, Calais L, Fuldauer G, Kushner R, Toney G, Lackey M, Mank A, Mahdavi N, Villarreal G, Muly E, Amin F, Dent M, Wold J, Fischer B, Elliott A, Felix C, Gill G, Parker P, Logan C, McAlpine J, DeLisi L, Reece S, Hammer M, Agbor‐Tabie D, Goodson W, Aslam M, Grainger M, Richtand N, Rybalsky A, Al Jurdi R, Boeckman E, Natividad T, Smith D, Stewart M, Torres S, Zhao Z, Mayeda A, Green A, Hofstetter J, Ngombu S, Scott M, Strasburger A, Sumner J, Paschall G, Mucciarelli J, Owen R, Theus S, Tompkins D, Potkin S, Reist C, Novin M, Khalaghizadeh S, Douyon R, Kumar N, Martinez B, Sponheim S, Bender T, Lucas H, Lyon A, Marggraf M, Sorensen L, Surerus C, Sison C, Amato J, Johnson D, Pagan‐Howard N, Adler L, Alerpin S, Leon T, Mattocks K, Araeva N, Sullivan J, Suppes T, Bratcher K, Drag L, Fischer E, Fujitani L, Gill S, Grimm D, Hoblyn J, Nguyen T, Nikolaev E, Shere L, Relova R, Vicencio A, Yip M, Hurford I, Acheampong S, Carfagno G, Haas G, Appelt C, Brown E, Chakraborty B, Kelly E, Klima G, Steinhauer S, Hurley R, Belle R, Eknoyan D, Johnson K, Lamotte J, Granholm E, Bradshaw K, Holden J, Jones R, Le T, Molina I, Peyton M, Ruiz I, Sally L, Tapp A, Devroy S, Jain V, Kilzieh N, Maus L, Miller K, Pope H, Wood A, Meyer E, Givens P, Hicks P, Justice S, McNair K, Pena J, Tharp D, Davis L, Ban M, Cheatum L, Darr P, Grayson W, Munford J, Whitfield B, Wilson E, Melnikoff S, Schwartz B, Tureson M, D Souza D, Forselius K, Ranganathan M, Rispoli L, Sather M, Colling C, Haakenson C, Kruegar D, Muralidhar S, Ramoni R, Breeling J, Chang K, O Donnell C, Tsao P, Moser J, Brewer J, Warren S, Argyres D, Stevens B, Humphries D, Do N, Shayan S, Nguyen X, Pyarajan S, Cho K, Hauser E, Sun Y, Wilson P, McArdle R, Dellitalia L, Harley J, Whittle J. Performance of Polygenic Risk Scores for Primary Open-Angle Glaucoma in Populations of African Descent. JAMA Ophthalmology 2025, 143: 7-14. PMID: 39541127, PMCID: PMC11565374, DOI: 10.1001/jamaophthalmol.2024.4784.Peer-Reviewed Original ResearchConceptsPrimary open-angle glaucomaEuropean ancestry groupsArea under the receiver operating characteristic curveAfrican descentSouth AfricaOpen-angle glaucomaCross-sectional studyIndividuals of African descentBaseline of ageAfrican ancestryOdds ratioGlaucoma patientsRisk stratificationMillion Veteran ProgramPolygenic risk scoresGenetics of glaucomaRisk scorePatients of African descentEuropean ancestryRisk quintileReceiver operating characteristic curveGhanaiansGhanaPopulations of African descentAmerican individuals
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