Bridget Chen
About
Biography
Originally from Michigan, Bridget attended Johns Hopkins University, where she earned her Bachelor of Science in Neuroscience with a second major in German, in 2019. Bridget began cultivating her interest in medicine and research as an undergraduate, when she joined a basic behavioral neuroscience lab led by Dr. Patricia Janak, to examine neural circuits involved in potentiating addictive behavior in rodents trained under various conditioning paradigms. Around the same time, she joined Dr. Rebecca Gottesman's stroke and neuroepidemiology lab, examining the interface between cardiovascular disease and neurological health and in particular, the potential causal link between stroke and dementia. In her gap year, Bridget had the opportunity to dissect factors driving racial health disparities in stroke care with Dr. Roland Faigle.
Clinically, her interests span from stroke neurology, cardiology to obstetrics and gynecology - with a special interest in pathophysiological perturbations and mental health challenges during perimenstrual and peripartum periods. For her PhD, Bridget is looking to explore the brain-body interface, in various physiological and pathological processes in Rui Chang's Lab - particularly, neuroimmune interactions in the periphery, the role of organ intrinsic neuronal populations, and peripheral neural pathways involved in reproductive function. Outside of research and medicine, she enjoys playing volleyball, pickleball, dancing, teaching ultrasound or neuroanatomy, mentorship, and learning about languages and cultures. She also loves playing with her two kittens and teaching them new tricks.
Education & Training
- BS (Hon)
- Johns Hopkins University, Neuroscience, German (2019)
Research
Overview
Medical Research Interests
Public Health Interests
ORCID
0000-0001-6167-8315
Research at a Glance
Publications Timeline
Research Interests
Publications
Featured Publications
Nucleus accumbens and dorsal medial striatal dopamine and neural activity are essential for action sequence performance
Chen BJ*, Fraser KM*, Janak PH. Nucleus accumbens and dorsal medial striatal dopamine and neural activity are essential for action sequence performance. Eur J Neurosci. 2023 Dec 13. doi: 10.1111/ejn.16210. Epub ahead of print. PMID: 38093522.Peer-Reviewed Original Research
2025
Contextual cues facilitate dynamic value encoding in the mesolimbic dopamine system
Fraser K, Collins V, Wolff A, Ottenheimer D, Bornhoft K, Pat F, Chen B, Janak P, Saunders B. Contextual cues facilitate dynamic value encoding in the mesolimbic dopamine system. Current Biology 2025, 35: 746-760.e5. PMID: 39855205, PMCID: PMC11859769, DOI: 10.1016/j.cub.2024.12.031.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsMesolimbic dopamine systemConditioned stimulusDopamine systemNucleus accumbensDopamine functionDopamine releaseOccasion setterDopamine neuronsActivity of ventral tegmental area dopamine neuronsVentral tegmental area dopamine neuronsTheory of dopamine functionNon-overlapping presentationSucrose deliverySucrose rewardContextual cuesBehavioral outputAdaptive behaviorDynamic environmental contextBehavioral responsesFemale ratsAccumbensStimuliSeeking behaviorDopamineMotor control
2024
Encoding and context-dependent control of reward consumption within the central nucleus of the amygdala
Fraser K, Kim T, Castro M, Drieu C, Padovan-Hernandez Y, Chen B, Pat F, Ottenheimer D, Janak P. Encoding and context-dependent control of reward consumption within the central nucleus of the amygdala. IScience 2024, 27: 109652. PMID: 38650988, PMCID: PMC11033178, DOI: 10.1016/j.isci.2024.109652.Peer-Reviewed Original ResearchConceptsCentral amygdalaCentral nucleus of the amygdalaEnhanced alcohol intakeOptogenetic stimulationAlcohol use disorderAmygdala neural activityCentral amygdala neuronsReward consumptionDrinking sucroseReward choicesUse disorderAberrant choiceAmygdala neuronsAmygdala stimulationCentral nucleusNeural activityAmygdalaReward approachRewardMale ratsActivity changesAlcohol intakeAlcoholIdentity optionsRatsEncoding and context-dependent control of reward consumption within the central nucleus of the amygdala
Fraser KM, Kim TH, Castro M, Drieu C, Padovan-Hernandez Y, Chen BJ, Pat F, Ottenheimer DJ, Janak PH, Encoding and context-dependent control of reward consumption within the central nucleus of the amygdala, ISCIENCE (2024), doi: https://doi.org/10.1016/j.isci.2024.109652.Peer-Reviewed Original Research In Press
2023
Nucleus accumbens and dorsal medial striatal dopamine and neural activity are essential for action sequence performance
Fraser K, Chen B, Janak P. Nucleus accumbens and dorsal medial striatal dopamine and neural activity are essential for action sequence performance. European Journal Of Neuroscience 2023, 59: 220-237. PMID: 38093522, PMCID: PMC10841748, DOI: 10.1111/ejn.16210.Peer-Reviewed Original ResearchConceptsNucleus accumbens coreDorsomedial striatumDopamine transmissionNeural activityFemale Long-Evans ratsLong-Evans ratsSequence performanceStriatal dopamineDopamine antagonistsDopamine antagonismNucleus accumbensStriatal circuitsDopamine systemDorsolateral striatumPharmacological inactivationAbsence of cuesAccumbens coreNumber of rewardsDistinct leversFlupenthixolInstrumental behaviorStriatumTask variationAction chainsAction sequencesAdvance directives among community-dwelling stroke survivors
Gupta S, Chen B, Suolang D, Cooper R, Faigle R. Advance directives among community-dwelling stroke survivors. PLOS ONE 2023, 18: e0292484. PMID: 37847705, PMCID: PMC10581473, DOI: 10.1371/journal.pone.0292484.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsCommunity-dwelling stroke survivorsPalliative care knowledgeStroke survivorsLife-sustaining treatmentAdvance directivesCare knowledgeAdvance careScale scoreLogistic regressionMultivariable logistic regressionCross-sectional studyMedian agePalliative careTreatment preferencesSurvivorsCareHealth careTreatment ScaleScoresAgeLower scoresPhysiciansPresent studyTreatmentParticipantsEncoding and context-dependent control of reward consumption within the central nucleus of the amygdala
Fraser KM, Kim TH, Castro M, Drieu C, Padovan-Hernandez Y, Chen BJ, Pat F, Ottenheimer DJ, Janak PH. Encoding and context-dependent control of reward consumption within the central nucleus of the amygdala. bioRxiv 2023.06.28.546936; doi: https://doi.org/10.1101/2023.06.28.546936Peer-Reviewed Original ResearchContexts facilitate dynamic value encoding in the mesolimbic dopamine system
Kurt M Fraser, Val L Collins, Amy R Wolff, David J Ottenheimer, Kaisa N Bornhoft, Fiona Pat, Bridget J Chen, Patricia H Janak, Benjamin T Saunders bioRxiv 2023.11.05.565687; doi: https://doi.org/10.1101/2023.11.05.565687Peer-Reviewed Original Research In Press
2022
Practice Patterns and Attitudes Among Speech–Language Pathologists Treating Stroke Patients with Dysphagia: A Nationwide Survey
Chen BJ, Suolang D, Frost N, Faigle R. Practice Patterns and Attitudes Among Speech–Language Pathologists Treating Stroke Patients with Dysphagia: A Nationwide Survey. Dysphagia 2022, 37: 1715-1722. PMID: 35274162, DOI: 10.1007/s00455-022-10432-6.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsSpeech-language pathologistsSwallow testingStroke patientsPractice patternsHigher oddsDysphagia managementPost-stroke dysphagia patientsPercutaneous endoscopic gastrostomy tubeOptimal timingQuality stroke careStroke center certificationPost-stroke dysphagiaAcute stroke patientsDysphagia testingAmerican Speech-LanguageStroke centersGastrostomy tubeStroke carePEG tubeSwallowing recoveryCenter certificationDysphagia patientsPatientsMore daysHearing AssociationTemporal Trends in Racial and Ethnic Disparities in Palliative Care Use After Intracerebral Hemorrhage in the United States
Suolang D, Chen BJ, Faigle R. Temporal Trends in Racial and Ethnic Disparities in Palliative Care Use After Intracerebral Hemorrhage in the United States. Stroke 2022, 53: e85-e87. PMID: 34983241, PMCID: PMC8885879, DOI: 10.1161/strokeaha.121.037182.Peer-Reviewed Original Research