2024
Neighborhood Food Access in Early Life and Trajectories of Child Body Mass Index and Obesity
Aris I, Wu A, Lin P, Zhang M, Farid H, Hedderson M, Zhu Y, Ferrara A, Chehab R, Barrett E, Carnell S, Camargo C, Chu S, Mirzakhani H, Kelly R, Comstock S, Strakovsky R, O’Connor T, Ganiban J, Dunlop A, Dabelea D, Breton C, Bastain T, Farzan S, Call C, Hartert T, Snyder B, Santarossa S, Cassidy-Bushrow A, O’Shea T, McCormack L, Karagas M, McEvoy C, Alshawabkeh A, Zimmerman E, Wright R, McCann M, Wright R, Coull B, Amutah-Onukagha N, Hacker M, James-Todd T, Oken E, Smith P, Newby L, Adair L, Jacobson L, Catellier D, McGrath M, Douglas C, Duggal P, Knapp E, Kress A, Blackwell C, Mansolf M, Lai J, Ho E, Cella D, Gershon R, Macy M, Das S, Freedman J, Mallal S, McLean J, Shah R, Shilts M, Alshawabkeh A, Cordero J, Meeker J, Trasande L, Camargo C, Hasegawa K, Zhu Z, Sullivan A, Dabelea D, Perng W, Bekelman T, Wilkening G, Magzamen S, Moore B, Starling A, Rinehart D, Koinis Mitchell D, D'Sa V, Deoni S, Mueller H, Duarte C, Monk C, Canino G, Posner J, Murray T, Lugo-Candelas C, Dunlop A, Brennan P, Hockett C, Elliott A, Ferrara A, Croen L, Hedderson M, Ainsworth J, Bacharier L, Bendixsen C, Gern J, Gold D, Hartert T, Jackson D, Johnson C, Joseph C, Kattan M, Khurana Hershey G, Lemanske, Jr. R, Lynch S, Miller R, O’Connor G, Ober C, Ownby D, Rivera-Spoljaric K, Ryan P, Seroogy C, Singh A, Wood R, Zoratti E, Habre R, Farzan S, Gilliland F, Hertz-Picciotto I, Bennett D, Schweitzer J, Schmidt R, LaSalle J, Hipwell A, Keenan K, Karr C, Bush N, LeWinn K, Sathyanarayana S, Zhao Q, Tylavsky F, Carroll K, Loftus C, Leve L, Ganiban J, Neiderhiser J, Weiss S, Litonjua A, McEvoy C, Spindel E, Tepper R, Newschaffer C, Lyall K, Volk H, Landa R, Ozonoff S, Piven J, Hazlett H, Pandey J, Schultz R, Dager S, Botteron K, Messinger D, Stone W, Ames J, O'Connor T, Miller R, Oken E, Hacker M, James-Todd T, O'Shea T, Fry R, Frazier J, Singh R, Rollins C, Montgomery A, Vaidya R, Joseph R, Washburn L, Gogcu S, Bear K, Rollins J, Hooper S, Taylor G, Jackson W, Thompson A, Daniels J, Hernandez M, Lu K, Msall M, Lenski M, Obeid R, Pastyrnak S, Jensen E, Sakai C, Santos H, Kerver J, Paneth N, Barone C, Elliott M, Ruden D, Fussman C, Herbstman J, Margolis A, Schantz S, Geiger S, Aguiar A, Tabb K, Strakovsky R, Woodruff T, Morello-Frosch R, Padula A, Stanford J, Porucznik C, Giardino A, Wright R, Wright R, Collett B, Baumann-Blackmore N, Gangnon R, McKennan C, Wilson J, Altman M, Aschner J, Stroustrup A, Merhar S, Moore P, Pryhuber G, Hudak M, Reynolds Lyndaker A, Lampland A, Rochelson B, Jan S, Blitz M, Katzow M, Brown Z, Chiuzan C, Rafael T, Lewis D, Meirowitz N, Poindexter B, Gebretsadik T, Osmundson S, Straughen J, Eapen A, Cassidy-Bushrow A, Wegienka G, Sitarik A, Woodcroft K, Urquhart A, Levin A, Johnson-Hooper T, Davidson B, Ma T, Barrett E, Blaser M, Dominguez-Bello M, Horton D, Jimenez M, Rosen T, Palomares K, Avalos L, Zhu Y, Hunt K, Newman R, Bloom M, Alkis M, Roberts J, Mumford S, Burris H, DeMauro S, Yee L, Hamvas A, Olidipo A, Haddad A, Eiland L, Spillane N, Suri K, Fisher S, Goldstein J, Mithal L, DeRegnier R, Maitre N, Nguyen R, JaKa M, Sidebottom A, Paidas M, Potter J, Ruby N, Duthely L, Jayakumar A, Young K, Maldonado I, Miller M, Slaughter J, Keim S, Lynch C, Venkatesh K, Whitworth K, Symanski E, Northrup T, Mendez-Figueroa H, Mosquera R, Karagas M, Madan J, MacKenzie D, Lewis J, Rennie B, Leventhal B, Kim Y, Bishop S, Nozadi S, Luo L, Lester B, Marsit C, Everson T, Loncar C, McGowan E, Sheinkopf S, Carter B, Check J, Helderman J, Neal C, Smith L. Neighborhood Food Access in Early Life and Trajectories of Child Body Mass Index and Obesity. JAMA Pediatrics 2024, 178: 1172-1182. PMID: 39283628, PMCID: PMC11406455, DOI: 10.1001/jamapediatrics.2024.3459.Peer-Reviewed Original ResearchConceptsChild body mass indexLow food accessBody mass indexNeighborhood food accessChild obesityObesity riskLow-incomeFood accessAccess neighborhoodsAssociated with higher BMI z-scoreHigher BMI z-scoreBody mass index z-scoreHigher risk of obesityPrevent child obesityHigher obesity riskGeocoded residential addressesIndividual sociodemographic characteristicsBMI z-scoreRisk of obesityZ-scoreImprove food accessLow-income neighborhoodsExposure in early lifeSevere obesityEarly lifeAssessment of immune cells in the uterine fluid at the time of the embryo transfer
Strbo N, Rodriguez S, Padula L, Fisher E, Lyons A, Rodriguez C, Rivas K, Ibrahim M, Paidas M, Attia G. Assessment of immune cells in the uterine fluid at the time of the embryo transfer. American Journal Of Reproductive Immunology 2024, 91: e13842. PMID: 38650366, DOI: 10.1111/aji.13842.Peer-Reviewed Original ResearchConceptsGamma delta T cellsFrozen embryo transferLower uterusAssisted reproductive technologyIn vitro fertilizationTransfer catheterT cellsEmbryo transferTime of implantationImmune milieuUpper uterusImmune cellsUltrasound guidanceExpression of CD4+ T cellsAssessment of immune cellsImprove IVF outcomesCD8+ T cellsCD4+ T cellsPopulation of T cellsComposition of immune cellsLower uterine segmentTime of embryo transferExpression of CD3+T regulatory cellsCD3+ cellsSpeculum-free portable preterm imaging system
Boonya-Ananta T, Gonzalez M, Ajmal A, Du Le V, DeHoog E, Paidas M, Jayakumar A, Ramella-Roman J. Speculum-free portable preterm imaging system. Journal Of Biomedical Optics 2024, 29: 052918-052918. PMID: 38282917, PMCID: PMC10821769, DOI: 10.1117/1.jbo.29.5.052918.Peer-Reviewed Original ResearchMeSH KeywordsCervix UteriChildFemaleHumansInfantInfant, NewbornPregnancyPremature BirthQuality of LifeConceptsNon-pregnant volunteersWeeks of gestationMortality rateNon-pregnant cervixCervical imagesPreterm birth riskStandard of careMaternal mortality rateUterine cervixPreterm birthPremature birthWomen's reproductive healthBirth riskCervixQuality of lifeDevelopmental impairmentReproductive healthBirthPatientsInfantsInfant mortality rateReducing infantInsertion sheathImaging probesPatient care
2023
Maternal SARS-CoV-2, Placental Changes and Brain Injury in 2 Neonates
Benny M, Bandstra E, Saad A, Lopez-Alberola R, Saigal G, Paidas M, Jayakumar A, Duara S. Maternal SARS-CoV-2, Placental Changes and Brain Injury in 2 Neonates. Pediatrics 2023, 151: e2022058271. PMID: 37021494, PMCID: PMC10467358, DOI: 10.1542/peds.2022-058271.Peer-Reviewed Original ResearchConceptsSARS-CoV-2SARS-CoV-2 infectionBrain injuryFetal brainSevere acute respiratory syndrome coronavirus disease 2Detectable SARS-CoV-2 antibodiesMaternal SARS-CoV-2 infectionSARS-CoV-2-positive mothersLong-term neurodevelopmental sequelaeMaternal SARS-CoV-2SARS-CoV-2 antibodiesStromal cell-derived factor-1Sudden unexpected infant deathInfant brainCell-derived factor-1Fetal vascular malperfusionSevere parenchymal atrophyHypoxic-ischemic encephalopathyBlood inflammatory markersUnexpected infant deathEarly-onset seizuresHuman chorionic gonadotropinOxidative stress injuryMonths of ageSARS-CoV-2 nucleocapsid protein
2015
Immune regulatory and neuroprotective properties of preimplantation factor: From newborn to adult
Barnea E, Almogi-Hazan O, Or R, Mueller M, Ria F, Weiss L, Paidas M. Immune regulatory and neuroprotective properties of preimplantation factor: From newborn to adult. Pharmacology & Therapeutics 2015, 156: 10-25. PMID: 26546485, DOI: 10.1016/j.pharmthera.2015.10.008.Peer-Reviewed Original ResearchConceptsPreImplantation FactorNeurological disordersAdverse maternal environmentSynthetic preimplantation factorEarly adverse eventsHigh safety profileFast track designationComplex neurological disorderEmbryonic-maternal interactionColon ulcerationPIF's effectHost diseaseLeukemia effectAdverse eventsLiver inflammationTransplant acceptanceBrain infectionNeuroprotective effectsAutoimmune disordersImmune suppressionNeuroprotective propertiesImmune modulationNeonatal prematuritySupraphysiological dosesSkin ulceration
2013
Exploring the Role of Antithrombin Replacement for the Treatment of Preeclampsia: A Prospective Randomized Evaluation of the Safety and Efficacy of Recombinant Antithrombin in Very Preterm Preeclampsia (PRESERVE‐1)
Paidas MJ, Sibai BM, Triche EW, Frieling J, Lowry S, Group T. Exploring the Role of Antithrombin Replacement for the Treatment of Preeclampsia: A Prospective Randomized Evaluation of the Safety and Efficacy of Recombinant Antithrombin in Very Preterm Preeclampsia (PRESERVE‐1). American Journal Of Reproductive Immunology 2013, 69: 539-544. PMID: 23444920, DOI: 10.1111/aji.12091.Peer-Reviewed Original ResearchConceptsProspective Randomized EvaluationAntithrombin replacementWeeks' gestationRandomized EvaluationRecombinant antithrombinTreatment of preeclampsiaRecombinant human ATExpectant managementPreterm preeclampsiaPrimary endpointMaternal indicationsGestational ageStudy enrollmentAT therapyPreeclampsia studyPreeclampsiaGestationHuman ATAT replacementPharmacokinetic activityAntithrombinEfficacySafetyLaboratory assaysDelivery
2012
PreImplantation Factor (PIF) orchestrates systemic antiinflammatory response by immune cells: effect on peripheral blood mononuclear cells
Barnea ER, Kirk D, Ramu S, Rivnay B, Roussev R, Paidas MJ. PreImplantation Factor (PIF) orchestrates systemic antiinflammatory response by immune cells: effect on peripheral blood mononuclear cells. American Journal Of Obstetrics And Gynecology 2012, 207: 313.e1-313.e11. PMID: 23021695, DOI: 10.1016/j.ajog.2012.07.017.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsPreImplantation FactorSynthetic PIFBlood mononuclear cellsLymphocyte reactionMononuclear cellsImmune cellsSystemic effectsNaïve peripheral blood mononuclear cellsSynthetic preimplantation factorSystemic antiinflammatory effectMixed lymphocyte reactionImmune-modulatory propertiesTumor necrosis factorGranulocyte-macrophage colony-stimulating factorColony-stimulating factorSPIF effectNonpregnant patientsDiabetes mellitusMale patientsAntiinflammatory effectsIL-4Immune modulationSubset populationsAntiinflammatory responseThrombophilias and adverse pregnancy outcomes: results from the Danish National Birth Cohort
LYKKE JA, BARE LA, OLSEN J, LAGIER R, ARELLANO AR, TONG C, PAIDAS MJ, LANGHOFF‐ROOS J. Thrombophilias and adverse pregnancy outcomes: results from the Danish National Birth Cohort. Journal Of Thrombosis And Haemostasis 2012, 10: 1320-1325. PMID: 22578003, DOI: 10.1111/j.1538-7836.2012.04773.x.Peer-Reviewed Original ResearchConceptsMethylenetetrahydrofolate reductase (MTHFR) C677TFetal growth restrictionProthrombin mutation G20210APlacental abruptionSevere preeclampsiaGrowth restrictionAllelic modelAdverse pregnancy outcomesBody mass indexCase-cohort studyReductase C677TPreterm deliveryComposite outcomePregnancy outcomesMass indexPregnant womenMedical recordsC677TFV LeidenStudy designSocioeconomic statusPreeclampsiaAbruptionRandom controlsOutcomes
2010
Mortality of mothers from cardiovascular and non‐cardiovascular causes following pregnancy complications in first delivery
Lykke JA, Langhoff‐Roos J, Lockwood CJ, Triche EW, Paidas MJ. Mortality of mothers from cardiovascular and non‐cardiovascular causes following pregnancy complications in first delivery. Paediatric And Perinatal Epidemiology 2010, 24: 323-330. PMID: 20618721, DOI: 10.1111/j.1365-3016.2010.01120.x.Peer-Reviewed Original ResearchConceptsNon-cardiovascular causesGestational age offspringEarly maternal deathPreterm deliveryCardiovascular causesHypertensive disordersPregnancy complicationsMaternal deathsEarly deathRegistry-based retrospective cohort studyCox proportional hazards modelFirst singleton deliveryMortality of mothersRetrospective cohort studyProportional hazards modelDenmark 1978Placental abruptionCohort studySingleton deliveriesLarge cohortFirst deliveryMortality hazardHazards modelSubsequent deathStrong markerA genomic and proteomic investigation of the impact of preimplantation factor on human decidual cells
Paidas MJ, Krikun G, Huang SJ, Jones R, Romano M, Annunziato J, Barnea ER. A genomic and proteomic investigation of the impact of preimplantation factor on human decidual cells. American Journal Of Obstetrics And Gynecology 2010, 202: 459.e1-459.e8. PMID: 20452489, PMCID: PMC2867836, DOI: 10.1016/j.ajog.2010.03.024.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cellsDown syndrome cell adhesion moleculeSyndrome cell adhesion moleculeGlobal gene expressionProtein arraysQuantitative mass spectrometryPreImplantation FactorBinding protein 1B-cell lymphoma protein 2PIF interactionProteomic analysisProteomic investigationCell adhesion moleculeInsulin-degrading enzymeGene expressionPathway analysisApoptotic pathwayApoptotic processToll-like receptor 5Protein 2Amino acid peptideProtein 1Protein 15Synthetic preimplantation factorEndometrial stromal cells
2009
Preterm delivery and risk of subsequent cardiovascular morbidity and type‐II diabetes in the mother
Lykke J, Paidas M, Damm P, Triche E, Kuczynski E, Langhoff‐Roos J. Preterm delivery and risk of subsequent cardiovascular morbidity and type‐II diabetes in the mother. BJOG An International Journal Of Obstetrics & Gynaecology 2009, 117: 274-281. PMID: 20015308, DOI: 10.1111/j.1471-0528.2009.02448.x.Peer-Reviewed Original ResearchConceptsRisk of thromboembolismType II diabetesPreterm deliveryCardiovascular morbiditySingleton deliveriesRegistry-based retrospective cohort studyCox proportional hazards modelFirst singleton deliveryHypertensive pregnancy disordersMaternal cardiovascular morbiditySecond singleton deliverySpecific cardiovascular eventsSubsequent cardiovascular morbidityRetrospective cohort studyIschemic heart diseaseWeeks of gestationYear of deliveryProportional hazards modelFetal growth deviationsMaternal hypertensionAdjusted riskCardiovascular eventsPlacental abruptionPregnancy complicationsCohort studyPulmonary embolism in pregnancy
Bourjeily G, Paidas M, Khalil H, Rosene-Montella K, Rodger M. Pulmonary embolism in pregnancy. The Lancet 2009, 375: 500-512. PMID: 19889451, DOI: 10.1016/s0140-6736(09)60996-x.Peer-Reviewed Original ResearchConceptsPulmonary embolismRisk of complicationsBest possible treatmentPotential adverse effectsAppropriate prophylaxisVenous thromboembolismRisk stratificationVenous stasisPregnant womenVascular damageVirchow's triadFetal teratogenicityMaternal mortalityPharmacological treatmentTherapeutic interventionsPregnancyPossible treatmentAccurate diagnosisDiagnostic testingRight populationAdverse effectsEmbolismMortalityPhysiological changesDiagnosisInvolvement of human decidual cell-expressed tissue factor in uterine hemostasis and abruption
Lockwood C, Paidas M, Murk W, Kayisli U, Gopinath A, Huang S, Krikun G, Schatz F. Involvement of human decidual cell-expressed tissue factor in uterine hemostasis and abruption. Thrombosis Research 2009, 124: 516-520. PMID: 19720393, PMCID: PMC2787516, DOI: 10.1016/j.thromres.2009.07.017.Peer-Reviewed Original ResearchConceptsDecidual cellsTissue factorPlacental ischemiaTF expressionDecidual cell-expressed tissue factorCultured term decidual cellsAutocrine/paracrine fashionDecidual spiral arteriesDecidual vascular remodelingTerm decidual cellsUteroplacental blood flowMaternal-fetal interfaceAutocrine/paracrine mediatorsDecidual infiltrationHemostatic protectionUterine hemostasisDecidual hemorrhageExtracellular matrixSpiral arteriesFetal interfaceHuman pregnancyVascular injuryConductance vesselsSFlt-1Interleukin-8Hypertensive Pregnancy Disorders and Subsequent Cardiovascular Morbidity and Type 2 Diabetes Mellitus in the Mother
Lykke JA, Langhoff-Roos J, Sibai BM, Funai EF, Triche EW, Paidas MJ. Hypertensive Pregnancy Disorders and Subsequent Cardiovascular Morbidity and Type 2 Diabetes Mellitus in the Mother. Hypertension 2009, 53: 944-951. PMID: 19433776, DOI: 10.1161/hypertensionaha.109.130765.Peer-Reviewed Original ResearchMeSH KeywordsAdultCardiovascular DiseasesCase-Control StudiesCohort StudiesDenmarkDiabetes Mellitus, Type 2FemaleHumansHypertension, Pregnancy-InducedIncidencePre-EclampsiaPregnancyPregnancy OutcomePregnancy RatePregnancy, High-RiskPremature BirthProbabilityProportional Hazards ModelsRegistriesSeverity of Illness IndexYoung AdultConceptsType 2 diabetes mellitusSubsequent type 2 diabetes mellitusHypertensive pregnancy disordersSubsequent cardiovascular eventsDiabetes mellitusGestational hypertensionSevere preeclampsiaPregnancy disordersSubsequent hypertensionCardiovascular eventsRegistry-based cohort studyConsecutive singleton deliveriesSubsequent cardiovascular morbidityCongestive heart failureIschemic heart diseaseCardiovascular morbidityPlacental abruptionPreterm deliveryThromboembolic eventsCohort studyMild preeclampsiaSingleton deliveriesHeart failureSubsequent thromboembolismGestational age
2008
Genetic influences on smoking cessation and relapse in pregnant women
Triche E, Hossain N, Paidas M. Genetic influences on smoking cessation and relapse in pregnant women. Journal Of Obstetrics And Gynaecology 2008, 28: 155-160. PMID: 18393009, DOI: 10.1080/01443610801912725.Peer-Reviewed Original ResearchConceptsLow birth weight infantsBirth weight infantsPregnant womenWeight infantsSmoking behaviorNegative long-term health consequencesLong-term health consequencesPre-term deliverySignificant public health concernFetal growth restrictionLow birth weightPublic health concernAuditory processing deficitsMaternal smokingObstetrical complicationsPlacental problemsCigarette smokingSmoking cessationBirth weightGrowth restrictionSpontaneous abortionPlacental functionLong-term consequencesRespiratory conditionsGenetic influences
2007
Do Thrombophilias Cause Placenta-Mediated Pregnancy Complications?
Rodger M, Paidas M. Do Thrombophilias Cause Placenta-Mediated Pregnancy Complications? Seminars In Thrombosis And Hemostasis 2007, 33: 597-603. PMID: 17768692, DOI: 10.1055/s-2007-985756.Peer-Reviewed Original ResearchConceptsPlacenta-mediated pregnancy complicationsPregnancy complicationsAnticoagulant prophylaxisIntrauterine growth restrictionThrombophilic pregnanciesNeonatal morbidityPlacental abruptionVenous thromboembolismThrombophilic womenPregnancy lossGrowth restrictionClinical consequencesHigh riskThrombophiliaComplicationsCausal associationProphylaxisAssociationThromboembolismAbruptionPreeclampsiaMorbidityEvidencePregnancyNew associationsEmbryo–Placento–Maternal Interaction and Biomarkers: From Diagnosis to Therapy – A Workshop Report
Than N, Paidas M, Mizutani S, Sharma S, Padbury J, Barnea E. Embryo–Placento–Maternal Interaction and Biomarkers: From Diagnosis to Therapy – A Workshop Report. Placenta 2007, 28: s107-s110. PMID: 17382999, PMCID: PMC2574429, DOI: 10.1016/j.placenta.2007.01.017.Peer-Reviewed Original Research
2005
Protein Z, protein S levels are lower in patients with thrombophilia and subsequent pregnancy complications
PAIDAS MJ, KU D, LEE M, MANISH S, THURSTON A, LOCKWOOD CJ, ARKEL YS. Protein Z, protein S levels are lower in patients with thrombophilia and subsequent pregnancy complications. Journal Of Thrombosis And Haemostasis 2005, 3: 497-501. PMID: 15748239, DOI: 10.1111/j.1538-7836.2005.01158.x.Peer-Reviewed Original ResearchConceptsAdverse pregnancy outcomesNormal pregnancy outcomeProtein S levelsPZ levelsPregnancy outcomesProtein SSubsequent pregnancy complicationsProtein ZAdditional risk factorsFree PS antigenPregnancy complicationsPregnant controlsThird trimesterPlasma levelsRisk factorsPatientsThrombophiliaPS antigenS levelsWomenSignificant decreasePS levelsOutcomesLow levelsTrimester
2004
Does heparin therapy improve pregnancy outcome in patients with thrombophilias?
Paidas M, Ku D, Triche E, Lockwood C, Arkel Y. Does heparin therapy improve pregnancy outcome in patients with thrombophilias? Journal Of Thrombosis And Haemostasis 2004, 2: 1194-1195. PMID: 15219211, DOI: 10.1111/j.1538-7836.2004.00784.x.Peer-Reviewed Original ResearchSoluble monocyte cluster domain 163, a new global marker of anti‐inflammatory response, is elevated in the first trimester of pregnancy
Paidas M, Ku D, Davis B, Lockwood C, Arkel Y. Soluble monocyte cluster domain 163, a new global marker of anti‐inflammatory response, is elevated in the first trimester of pregnancy. Journal Of Thrombosis And Haemostasis 2004, 2: 1009-1010. PMID: 15140143, DOI: 10.1111/j.1538-7836.2004.00681.x.Peer-Reviewed Original Research