Mechanism of Alzheimer type II astrocyte development in hepatic encephalopathy
Tong X, Norenberg M, Paidas M, Shamaladevi N, Salgueiro L, Jaszberenyi M, John B, Hussain H, El Hiba O, Abdeljalil E, Bilal E, Natarajan S, Romaguera R, Papayan S, Carden A, Ramamoorthy R, Elumalai N, Schally A, Nithura J, Patrizio R, Jayakumar A. Mechanism of Alzheimer type II astrocyte development in hepatic encephalopathy. Neurochemistry International 2024, 180: 105866. PMID: 39369794, DOI: 10.1016/j.neuint.2024.105866.Peer-Reviewed Original ResearchType C HEMotor deficitsChronic liver failureHuman post-mortem brain sectionsLiver failureC HEInflammatory factorsOxidative/nitrosative stressPost-mortem brain sectionsIncreased levelsType C hepatic encephalopathyDeficitsMotor disturbancesLevels of inflammatory factorsTreatment in vitroTAA-treated ratsBrain sectionsLevels of GFAPHistopathological findingsIncreased oxidative/nitrosative stressHepatic encephalopathyW-7Pharmacological inhibitionAstrocyte culturesMotorAge and Sex in the Development of Hepatic Encephalopathy: Role of Alcohol
Tong X, Hussain H, Shamaladevi N, Norenberg M, Fadel A, Hiba O, Abdeljalil E, El-Mansoury B, Kempuraj D, Natarajan S, Schally A, Jaszberenyi M, Salgueiro L, Paidas M, Jayakumar A. Age and Sex in the Development of Hepatic Encephalopathy: Role of Alcohol. Biology 2024, 13: 228. PMID: 38666840, PMCID: PMC11048384, DOI: 10.3390/biology13040228.Peer-Reviewed Original ResearchFemale ratsMiddle-aged ratsAged male ratsAged female ratsBehavioral deficitsType C HEHepatic encephalopathyBrain edemaTAA-induced HELiver failureAged malesAged femalesMale ratsBehavioral changesAdult ratsChronic HEDevelopment of hepatic encephalopathySustained plasma levelsAcute liver failureMiddle-agedEtOHAcute HEC HEBrainDrug-induced