2024
Age and Sex in the Development of Hepatic Encephalopathy: Role of Alcohol
Tong X, Hussain H, Shamaladevi N, Norenberg M, Fadel A, Hiba O, Abdeljalil E, El-Mansoury B, Kempuraj D, Natarajan S, Schally A, Jaszberenyi M, Salgueiro L, Paidas M, Jayakumar A. Age and Sex in the Development of Hepatic Encephalopathy: Role of Alcohol. Biology 2024, 13: 228. PMID: 38666840, PMCID: PMC11048384, DOI: 10.3390/biology13040228.Peer-Reviewed Original ResearchFemale ratsMiddle-aged ratsAged male ratsAged female ratsBehavioral deficitsType C HEHepatic encephalopathyBrain edemaTAA-induced HELiver failureAged malesAged femalesMale ratsBehavioral changesAdult ratsChronic HEDevelopment of hepatic encephalopathySustained plasma levelsAcute liver failureMiddle-agedEtOHAcute HEC HEBrainDrug-induced
2010
WAG‐F8m1Ycb rats harboring a factor VIII gene mutation provide a new animal model for hemophilia A
BOOTH CJ, BROOKS MB, ROCKWELL S, MURPHY JW, RINDER HM, ZELTERMAN D, PAIDAS MJ, COMPTON SR, MARKS PW. WAG‐F8m1Ycb rats harboring a factor VIII gene mutation provide a new animal model for hemophilia A. Journal Of Thrombosis And Haemostasis 2010, 8: 2472-2477. PMID: 20626616, DOI: 10.1111/j.1538-7836.2010.03978.x.Peer-Reviewed Original ResearchConceptsAutosomal locationX chromosomeGenetic basisFactor VIIITertiary structureChromosome 18Point mutationsA1 domainFactor activityGenetic defectsHuman recombinant factor VIIIPartial thromboplastin timeSpecific coagulation factorsNew animal modelNormal prothrombin timeFactor VIII gene mutationsRecombinant factor VIIIMutationsPeripartum deathsGene mutationsCoagulation abnormalitiesSpontaneous bruisingProthrombin timeFemale ratsNovel therapies