Neuroengineering
We are engaged in development of neurotechnology for monitoring and modulating brain activity
Research
Neuroengineering
Yale Brain Atlas
We have created the Yale brain atlas - a structural map of the brain parcellated into 696 different regions for aggregating multimodal data, including imaging, electrophysiology and functional stimulation mapping. This is a multimodal cortical atlas for testing function-structure hypotheses and to aid clinical decision making in epilepsy surgery.Computational Neurophysiology
Our research on computational neurophysiology is focused on improving our understanding of epilepsy and the control of seizures. In our work on epilepsy, we seek to employ our knowledge of seizure generation, sophisticated continuous brain sensing methods, and advanced computational methods for seizure forecasting and localizing the seizure onset area.Neurochemistry
We use mass spectrometry and chemistry sensors to study the metabolome of cyclical brain disorders, such as epilepsy, addiction, and mood disorders.
Publications
- Combined neuromodulation and resection for functional cortex epilepsy: a case series.Merenzon MA, Sivaraju A, Herlopian A, Gerrard JL, Quraishi IH, Hirsch LJ, Spencer DD, Damisah EC. J Neurosurg. 2024 Dec 1; 2024 Jun 7. PMID: 38848588.
- Modeling seizure networks in neuron-glia cultures using microelectrode arrays.Boddeti U, Langbein J, McAfee D, Altshuler M, Bachani M, Zaveri HP, Spencer D, Zaghloul KA, Ksendzovsky A. Front Netw Physiol. 2024; 2024 Sep 3. PMID: 39290793.
- Stability of infraslow correlation structure in time-shifted intracranial EEG signals.Joshi RB, Duckrow RB, Goncharova II, Hirsch LJ, Spencer DD, Godwin DW, Zaveri HP. Front Netw Physiol. 2024; 2024 Aug 27. PMID: 39258030.
- Mapping the structure-function relationship along macroscale gradients in the human brain.Collins E, Chishti O, Obaid S, McGrath H, King A, Shen X, Arora J, Papademetris X, Constable RT, Spencer DD, Zaveri HP. Nat Commun. 2024 Aug 16; 2024 Aug 16. PMID: 39152127.
- Seizing Control: Primary Visual Cortex Epilepsy Treated With Resection and Responsive Neurostimulation: 2-Dimensional Operative Video.Merenzon MA, Lamsam L, McGrath H, Sivaraju A, Hirsch LJ, Cukiert A, Zibly Z, Spencer DD, Damisah EC. Oper Neurosurg (Hagerstown). 2024 Aug 1; 2024 Mar 7. PMID: 39007609.
- Functional parcellation of the cingulate gyrus by electrical cortical stimulation: a synthetic literature review and future directions.Mahgoub R, Bayram AK, Spencer DD, Alkawadri R. J Neurol Neurosurg Psychiatry. 2024 Jul 15; 2024 Jul 15. PMID: 38242679.
- Optimized Multilayer Perceptron for Sensorimotor Functional Mapping Based on a Few Minutes of Intracranial Electroencephalogram Data.Iktimal A, Spencer DD, Alkawadri R. Ann Neurol. 2024 Jul; 2024 Mar 20. PMID: 38506405.
- Systematic 1 Hz direct electrical stimulation for seizure induction: A reliable method for localizing seizure onset zone and predicting seizure freedom.Sivaraju A, Quraishi I, Collins E, McGrath H, Ramos A, Turk-Browne NB, Zaveri H, Damisah E, Spencer DD, Hirsch LJ. Brain Stimul. 2024 Mar-Apr; 2024 Mar 13. PMID: 38490472.
- Editorial for 'focus collection in memory of Prof Mark A Reed'.Calvet L, Guan W, Klemic J, Lee T, Nami M, Sleight J, Stern E, Yosinski S, Zhou C. Nanotechnology. 2023 Dec 27; 2023 Dec 27. PMID: 38149961.
- Seizure forecasting: Where do we stand?Andrzejak RG, Zaveri HP, Schulze-Bonhage A, Leguia MG, Stacey WC, Richardson MP, Kuhlmann L, Lehnertz K. Epilepsia. 2023 Dec; 2023 Mar 8. PMID: 36780237.
- Outcomes in Patients With Poststroke Seizures: A Systematic Review and Meta-Analysis.Misra S, Kasner SE, Dawson J, Tanaka T, Zhao Y, Zaveri HP, Eldem E, Vazquez J, Silva LS, Mohidat S, Hickman LB, Khan EI, Funaro MC, Nicolo JP, Mazumder R, Yasuda CL, Sunnerhagen KS, Ihara M, Ross JS, Liebeskind DS, Kwan P, Quinn TJ, Engel J Jr, Mishra NK. JAMA Neurol. 2023 Nov 1. PMID: 37721736.
- Nicotine flux as a powerful tool for regulating nicotine delivery from e-cigarettes: Protocol of two complimentary randomized crossover clinical trials.El-Hellani A, Hanna E, Sharma M, Blohowiak R, Joseph P, Eid T, Nadim H, El-Hage R, Salman R, Karaoghlanian N, Adeniji A, Salam S, Talih F, Elbejjani M, Breland A, Eissenberg T, Shihadeh A, Baldassarri SR, Talih S. PLoS One. 2023; 2023 Sep 21. PMID: 37733666.
- SOX7 deficiency causes ventricular septal defects through its effects on endocardial-to-mesenchymal transition and the expression of Wnt4 and Bmp2.Hernández-García A, Pendleton KE, Kim S, Li Y, Kim BJ, Zaveri HP, Jordan VK, Berry AM, Ljungberg MC, Chen R, Lanz RB, Scott DA. Hum Mol Genet. 2023 Jun 19. PMID: 37000005.
- Contribution of Somatic Ras/Raf/Mitogen-Activated Protein Kinase Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy.Khoshkhoo S, Wang Y, Chahine Y, Erson-Omay EZ, Robert SM, Kiziltug E, Damisah EC, Nelson-Williams C, Zhu G, Kong W, Huang AY, Stronge E, Phillips HW, Chhouk BH, Bizzotto S, Chen MH, Adikari TN, Ye Z, Witkowski T, Lai D, Lee N, Lokan J, Scheffer IE, Berkovic SF, Haider S, Hildebrand MS, Yang E, Gunel M, Lifton RP, Richardson RM, Blümcke I, Alexandrescu S, Huttner A, Heinzen EL, Zhu J, Poduri A, DeLanerolle N, Spencer DD, Lee EA, Walsh CA, Kahle KT. JAMA Neurol. 2023 Jun 1. PMID: 37126322.
- Quantitative assessment of burst suppression as a predictor of seizure recurrence in refractory status epilepticus.Fong MWK, Pu K, Jadav R, Khan T, Hirsch LJ, Zaveri HP. Clin Neurophysiol. 2023 Jun; 2023 Mar 30. PMID: 37060844.
- Exploring CITEs of Inflammation in the Human Epilepsy Brain.Eid T. Epilepsy Curr. 2023 May-Jun; 2023 Apr 11. PMID: 37334410.
- Transfrontal Approach to the Amygdala for Ablation With Laser Interstitial Thermal Therapy: An Epilepsy Case Report.Lamsam L, Brigido MM, Sivaraju A, Hirsch LJ, Spencer DD, Chiang V, Damisah E. Oper Neurosurg (Hagerstown). 2023 May 1; 2023 Jan 2. PMID: 36715982.
- Recent advances in epilepsy surgery.Medina-Pizarro M, Spencer DD, Damisah EC. Curr Opin Neurol. 2023 Apr 1; 2023 Jan 31. PMID: 36762633.
- Threshold for the pleasurable effects of nicotine are lower than its reinforcing effects during self-administration.MacLean RR, Eid T, Parida S, Gueorguieva R, DeVito EE, Sofuoglu M. Exp Clin Psychopharmacol. 2023 Feb; 2022 Mar 7. PMID: 35254839.
- Age-dependent vestibular cingulate-cerebral network underlying gravitational perception: a cross-sectional multimodal study.Plute TJ, Spencer DD, Alkawadri R. Brain Inform. 2022 Dec 21; 2022 Dec 21. PMID: 36542188.
- High-resolution cortical parcellation based on conserved brain landmarks for localization of multimodal data to the nearest centimeter.McGrath H, Zaveri HP, Collins E, Jafar T, Chishti O, Obaid S, Ksendzovsky A, Wu K, Papademetris X, Spencer DD. Sci Rep. 2022 Nov 5; 2022 Nov 5. PMID: 36335146.
- A companion to the preclinical common data elements for proteomics, lipidomics, and metabolomics data in rodent epilepsy models. A report of the TASK3-WG4 omics working group of the ILAE/AES joint translational TASK force.Bindila L, Eid T, Mills JD, Hildebrand MS, Brennan GP, Masino SA, Whittemore V, Perucca P, Reid CA, Patel M, Wang KK, van Vliet EA. Epilepsia Open. 2022 Oct 18; 2022 Oct 18. PMID: 36259125.
- The changing landscape in epilepsy imaging: Unmasking subtle and unique entities.Adin ME, Durand D, Zucconi WB, Huttner AJ, Spencer DD, Bronen RA. Diagn Interv Radiol. 2022 Sep. PMID: 35997478.
- Tongue as a Wire? Glossokinetic Artifact and Insights From Intracranial EEG.Bayram AK, Spencer DD, Alkawadri R. J Clin Neurophysiol. 2022 Sep 1; 2021 Feb 15. PMID: 34411027.
- Passive localization of the central sulcus during sleep based on intracranial EEG.Alkawadri R, Zaveri HP, Sheth KN, Spencer DD. Cereb Cortex. 2022 Aug 22. PMID: 34921723.
- A companion to the preclinical common data elements for genomics, transcriptomics, and epigenomics data in rodent epilepsy models. A report of the TASK3-WG4 omics working group of the ILAE/AES joint translational TASK force.van Vliet EA, Hildebrand MS, Mills JD, Brennan GP, Eid T, Masino SA, Whittemore V, Bindila L, Wang KK, Patel M, Perucca P, Reid CA. Epilepsia Open. 2022 Aug 11; 2022 Aug 11. PMID: 35950645.
- Cellular recovery after prolonged warm ischaemia of the whole body.Andrijevic D, Vrselja Z, Lysyy T, Zhang S, Skarica M, Spajic A, Dellal D, Thorn SL, Duckrow RB, Ma S, Duy PQ, Isiktas AU, Liang D, Li M, Kim SK, Daniele SG, Banu K, Perincheri S, Menon MC, Huttner A, Sheth KN, Gobeske KT, Tietjen GT, Zaveri HP, Latham SR, Sinusas AJ, Sestan N. Nature. 2022 Aug; 2022 Aug 3. PMID: 35922506.
- Factors Predicting Outcome After Intracranial EEG Evaluation in Patients With Medically Refractory Epilepsy.Sivaraju A, Hirsch L, Gaspard N, Farooque P, Gerrard J, Xu Y, Deng Y, Damisah E, Blumenfeld H, Spencer DD. Neurology. 2022 Jul 5; 2022 May 4. PMID: 35508395.
- Catch the Rhythm!Eid T, Zaveri HP. Epilepsy Curr. 2022 Jul-Aug; 2022 Apr 26. PMID: 36187149.
- Rapid Screen for Antiviral T-Cell Immunity with Nanowire Electrochemical Biosensors.Nami M, Han P, Hanlon D, Tatsuno K, Wei B, Sobolev O, Pitruzzello M, Vassall A, Yosinski S, Edelson R, Reed M. Adv Mater. 2022 Jul; 2022 Mar 25. PMID: 35165959.
- The neural networks underlying the illusion of time dilation: case study and literature survey.Sheikh M, Koubeissi M, Constable RT, Spencer DD, Alkawadri R. Epileptic Disord. 2022 Jun 1. PMID: 35653087.
- Prognostication of responsive neurostimulation system responsiveness using presurgical magnetoencephalography.Joshi RB, Zaveri HP. Brain Commun. 2022; 2022 May 9. PMID: 35611311.
- Perspectives on Understanding Aberrant Brain Networks in Epilepsy.Sinha N, Joshi RB, Sandhu MRS, Netoff TI, Zaveri HP, Lehnertz K. Front Netw Physiol. 2022; 2022 Apr 5. PMID: 36926081.
- Effects of Bovine Hemoglobin on Chemistry Testing: Pseudohemolysis or Real?Vera MA, Eid T, El-Khoury JM. Clin Chem. 2022 Mar 31. PMID: 36103316.
- Plasma Menthol Glucuronide as a Biomarker for the Behavioral Effects of Menthol and Nicotine in Humans.Gueorguieva R, Schwartz EKC, MacLean RR, DeVito EE, Eid T, Wu R, O'Malley SS, Sofuoglu M. Front Pharmacol. 2022; 2022 Mar 31. PMID: 35431934.
- Harnessing Metabolomics to Advance Epilepsy Research.Eid T. Epilepsy Curr. 2022 Mar-Apr; 2022 Feb 17. PMID: 35444500.
- Transforming Glia to Neurons Effectively Treats Temporal Lobe Seizures.Eid T. Epilepsy Curr. 2022 Mar-Apr; 2022 Jan 8. PMID: 35444496.
- Impact of delivery rate on the acute response to intravenous nicotine: A human laboratory study with implications for regulatory science.De Aquino JP, MacLean RR, Gueorguieva R, DeVito EE, Eid T, Sofuoglu M. Addict Biol. 2022 Mar. PMID: 35229960.
- Optimizing the surgical management of MRI-negative epilepsy in the neuromodulation era.McGrath H, Mandel M, Sandhu MRS, Lamsam L, Adenu-Mensah N, Farooque P, Spencer DD, Damisah EC. Epilepsia Open. 2022 Mar; 2022 Feb 1. PMID: 35038792.
- Management of patients with medically intractable epilepsy and anterior temporal lobe encephaloceles.Sandhu MRS, Mandel M, McGrath H, Lamsam L, Farooque P, Bronen RA, Spencer DD, Damisah EC. J Neurosurg. 2022 Mar 1; 2021 Sep 10. PMID: 34507290.
- International Post Stroke Epilepsy Research Consortium (IPSERC): A consortium to accelerate discoveries in preventing epileptogenesis after stroke.Mishra NK, Engel J Jr, Liebeskind DS, Sharma VK, Hirsch LJ, Kasner SE, French JA, Devinsky O, Friedman A, Dawson J, Quinn TJ, Selim M, de Havenon A, Yasuda CL, Cendes F, Benninger F, Zaveri HP, Burneo JG, Srivastava P, Bhushan Singh M, Bhatia R, Vishnu VY, Bentes C, Ferro J, Weiss S, Sivaraju A, Kim JA, Galovic M, Gilmore EJ, Pitkänen A, Davis K, Sansing LH, Sheth KN, Paz JT, Singh A, Sheth S, Worrall BB, Grotta JC, Casillas-Espinos PM, Chen Z, Nicolo JP, Yan B, Kwan P. Epilepsy Behav. 2022 Feb; 2021 Dec 27. PMID: 34968775.
- Combining Transcranial Doppler and EEG Data to Predict Delayed Cerebral Ischemia After Subarachnoid Hemorrhage.Chen HY, Elmer J, Zafar SF, Ghanta M, Moura Junior V, Rosenthal ES, Gilmore EJ, Hirsch LJ, Zaveri HP, Sheth KN, Petersen NH, Westover MB, Kim JA. Neurology. 2022 Feb 1; 2021 Nov 29. PMID: 34845057.
- The Neural Networks Underlying the Illusion of Time Dilation.Sheikh MM, Koubeissi MZ, Spencer DD, Alkawadri R. Ann Neurol. 2022 Feb; 2021 Dec 13. PMID: 34841572.
- Designing Sensitivity: A Comparative Analysis of Microelectrode Topologies for Electrochemical Oxygen Sensing in Biomedical Applications.Bacheschi DT, Strittmatter EZ, Sawtelle S, Nami M. Micromachines (Basel). 2022 Jan 17; 2022 Jan 17. PMID: 35056306.
- Oral glutamine supplementation increases seizure severity in a rodent model of mesial temporal lobe epilepsy.Dhaher R, Chen EC, Perez E, Rapuano A, Sandhu MRS, Gruenbaum SE, Deshpande K, Dai F, Zaveri HP, Eid T. Nutr Neurosci. 2022 Jan; 2020 Jan 3. PMID: 31900092.
- Etched-And-Regrown GaN P-N Diodes with Low-Defect Interfaces Prepared by In Situ TBCl Etching.Li B, Wang S, Nami M, Armstrong AM, Han J. ACS Appl Mater Interfaces. 2021 Nov 10; 2021 Oct 27. PMID: 34706193.
- Brain Energy Oscillations-A Possible Explanation for Seizure Periodicity in Epilepsy?Eid T. Epilepsy Curr. 2021 Nov-Dec; 2021 Oct 7. PMID: 34924854.
- Small loci of astroglial glutamine synthetase deficiency in the postnatal brain cause epileptic seizures and impaired functional connectivity.Farina MG, Sandhu MRS, Parent M, Sanganahalli BG, Derbin M, Dhaher R, Wang H, Zaveri HP, Zhou Y, Danbolt NC, Hyder F, Eid T. Epilepsia. 2021 Nov; 2021 Sep 18. PMID: 34536233.
- Progressive Neuronal Loss in Epilepsy - A Long-Standing Conundrum Finally Resolved?Eid T. Epilepsy Curr. 2021 Oct; 2021 Jul 17. PMID: 34924838.
- Imaging of Neuromodulation and Surgical Interventions for Epilepsy.Adin ME, Spencer DD, Damisah E, Herlopian A, Gerrard JL, Bronen RA. AJNR Am J Neuroradiol. 2021 Oct; 2021 Aug 5. PMID: 34353787.
- Gerstmann Syndrome Deconstructed by Cortical Stimulation.Vaddiparti A, McGrath H, Benjamin CFA, Sivaraju A, Spencer DD, Hirsch LJ, Damisah E, Quraishi IH. Neurology. 2021 Aug 31; 2021 Jun 29. PMID: 34187861.
- Threshold dose for intravenous nicotine self-administration in young adult non-dependent smokers.MacLean RR, DeVito EE, Eid T, Parida S, Gueorguieva R, Sofuoglu M. Psychopharmacology (Berl). 2021 Aug; 2021 Apr 1. PMID: 33796907.
- Influence of menthol and green apple e-liquids containing different nicotine concentrations among youth e-cigarette users.Jackson A, Green B, Erythropel HC, Kong G, Cavallo DA, Eid T, Gueorguieva R, Buta E, O'Malley SS, Krishnan-Sarin S. Exp Clin Psychopharmacol. 2021 Aug; 2020 Apr 16. PMID: 32297782.
- Localizing the Seizure Onset Site Through Metabolic Imaging of GABA.Eid T. Epilepsy Curr. 2021 Jul-Aug; 2021 Apr 28. PMID: 34690567.
- Artificial neural network trained on smartphone behavior can trace epileptiform activity in epilepsy.Duckrow RB, Ceolini E, Zaveri HP, Brooks C, Ghosh A. iScience. 2021 Jun 25; 2021 May 13. PMID: 34308281.
- Increased branched-chain amino acids at baseline and hours before a spontaneous seizure in the human epileptic brain.Ong C, Damisah EC, Gruenbaum SE, Dhaher R, Deng Y, Sandhu MRS, Zaveri HP, Spencer DD, Eid T. Epilepsia. 2021 Jun; 2021 May 5. PMID: 33949690.
- Altered hippocampal astroglial metabolism is associated with aging and preserved spatial learning and memory.Ebersole J, Rose G, Eid T, Behar K, Patrylo P. Neurobiol Aging. 2021 Jun; 2021 Feb 26. PMID: 33774381.
- RERE deficiency contributes to the development of orofacial clefts in humans and mice.Kim BJ, Zaveri HP, Kundert PN, Jordan VK, Scott TM, Carmichael J, Scott DA. Hum Mol Genet. 2021 May 12. PMID: 33772547.
- Network-Related Changes in Neurotransmitters and Seizure Propagation During Rodent Epileptogenesis.Dhaher R, Gruenbaum SE, Sandhu MRS, Ottestad-Hansen S, Tu N, Wang Y, Lee TW, Deshpande K, Spencer DD, Danbolt NC, Zaveri HP, Eid T. Neurology. 2021 May 4; 2021 Mar 15. PMID: 33722994.
- Intrastimulation discharges during electrical stimulation mapping May help identify seizure onset network.Sivaraju A, Spencer DD, Hirsch LJ. Brain Stimul. 2021 May-Jun; 2021 Apr 4. PMID: 33826933.
- Effect of anesthesia on electrocorticography for localization of epileptic focus: Literature review and future directions.Kacar Bayram A, Yan Q, Isitan C, Rao S, Spencer DD, Alkawadri R. Epilepsy Behav. 2021 May; 2021 Apr 2. PMID: 33819715.
- Video quality using outpatient smartphone videos in epilepsy: Results from the OSmartViE study.Tatum WO, Hirsch LJ, Gelfand MA, Acton EK, LaFrance WC, Duckrow RB, Chen D, Blum AS, Hixson J, Drazkowski J, Benbadis S, Cascino GD. Eur J Neurol. 2021 May; 2021 Feb 11. PMID: 33465822.
- Astroglial Glutamine Synthetase and the Pathogenesis of Mesial Temporal Lobe Epilepsy.Sandhu MRS, Gruenbaum BF, Gruenbaum SE, Dhaher R, Deshpande K, Funaro MC, Lee TW, Zaveri HP, Eid T. Front Neurol. 2021; 2021 Apr 13. PMID: 33927688.
- Ticktock-What Is the Seizure Driving Clock?Eid T. Epilepsy Curr. 2021 Mar-Apr; 2021 Jan 29. PMID: 34025290.
- Graph-based risk assessment and error detection in radiation therapy.Munbodh R, Bowles JK, Zaveri HP. Med Phys. 2021 Mar; 2021 Feb 6. PMID: 33340128.
- Electrical cortical stimulation can impair production of the alphabet without impairing counting.Rojas PH, Sivaraju A, Quraishi IH, Vanderlind M, Rofes A, Połczynska-Bletsos MM, Spencer DD, Hirsch LJ, Benjamin CFA. Epilepsy Behav Rep. 2021; 2021 Feb 11. PMID: 33778464.
- Gene expression in the epileptic (EL) mouse hippocampus.Lee TS, Li AY, Rapuano A, Mantis J, Eid T, Seyfried TN, de Lanerolle NC. Neurobiol Dis. 2021 Jan; 2020 Oct 24. PMID: 33153970.
- Ectopic HCN4 expression drives mTOR-dependent epilepsy in mice.Hsieh LS, Wen JH, Nguyen LH, Zhang L, Getz SA, Torres-Reveron J, Wang Y, Spencer DD, Bordey A. Sci Transl Med. 2020 Nov 18. PMID: 33208499.
- Novel aspects of glutamine synthetase in ammonia homeostasis.Zhou Y, Eid T, Hassel B, Danbolt NC. Neurochem Int. 2020 Nov; 2020 Aug 3. PMID: 32758585.
- Evaluating the effect of switching to non-menthol cigarettes among current menthol smokers: an empirical study of a potential ban of characterising menthol flavour in cigarettes.Bold KW, Jatlow P, Fucito LM, Eid T, Krishnan-Sarin S, O'Malley S. Tob Control. 2020 Nov; 2019 Nov 4. PMID: 31685586.
- Reduced synaptic vesicle protein 2A binding in temporal lobe epilepsy: A [(11) C]UCB-J positron emission tomography study.Finnema SJ, Toyonaga T, Detyniecki K, Chen MK, Dias M, Wang Q, Lin SF, Naganawa M, Gallezot JD, Lu Y, Nabulsi NB, Huang Y, Spencer DD, Carson RE. Epilepsia. 2020 Oct; 2020 Sep 18. PMID: 32944949.
- Brief history of electrical cortical stimulation: A journey in time from Volta to Penfield.Isitan C, Yan Q, Spencer DD, Alkawadri R. Epilepsy Res. 2020 Oct; 2020 May 22. PMID: 32673971.
- Beyond implantation effect? Long-term seizure reduction and freedom following intracranial monitoring without additional surgical interventions.Percy J, Zaveri H, Duckrow RB, Gerrard J, Farooque P, Hirsch LJ, Spencer DD, Sivaraju A. Epilepsy Behav. 2020 Oct; 2020 Jun 29. PMID: 32615416.
- The connectivity index: an effective metric for grading epileptogenicity.Yan Q, Gaspard N, Zaveri HP, Blumenfeld H, Hirsch LJ, Spencer DD, Alkawadri R. J Neurosurg. 2020 Oct 1; 2019 Sep 27. PMID: 31561212.
- Nine-year prospective efficacy and safety of brain-responsive neurostimulation for focal epilepsy.Nair DR, Laxer KD, Weber PB, Murro AM, Park YD, Barkley GL, Smith BJ, Gwinn RP, Doherty MJ, Noe KH, Zimmerman RS, Bergey GK, Anderson WS, Heck C, Liu CY, Lee RW, Sadler T, Duckrow RB, Hirsch LJ, Wharen RE Jr, Tatum W, Srinivasan S, McKhann GM, Agostini MA, Alexopoulos AV, Jobst BC, Roberts DW, Salanova V, Witt TC, Cash SS, Cole AJ, Worrell GA, Lundstrom BN, Edwards JC, Halford JJ, Spencer DC, Ernst L, Skidmore CT, Sperling MR, Miller I, Geller EB, Berg MJ, Fessler AJ, Rutecki P, Goldman AM, Mizrahi EM, Gross RE, Shields DC, Schwartz TH, Labar DR, Fountain NB, Elias WJ, Olejniczak PW, Villemarette-Pittman NR, Eisenschenk S, Roper SN, Boggs JG, Courtney TA, Sun FT, Seale CG, Miller KL, Skarpaas TL, Morrell MJ. Neurology. 2020 Sep 1; 2020 Jul 20. PMID: 32690786.
- Diagnosis and Management of pituitary disease with focus on the role of Magnetic Resonance Imaging.Mahajan A, Bronen RA, Mian AY, Omay SB, Spencer DD, Inzucchi SE. Endocrine. 2020 Jun; 2020 Mar 11. PMID: 32162185.
- Circadian-Like Rhythmicity of Extracellular Brain Glutamate in Epilepsy.Sandhu MRS, Dhaher R, Gruenbaum SE, Raaisa R, Spencer DD, Pavlova MK, Zaveri HP, Eid T. Front Neurol. 2020; 2020 May 15. PMID: 32499751.
- Controversies on the network theory of epilepsy: Debates held during the ICTALS 2019 conference.Zaveri HP, Schelter B, Schevon CA, Jiruska P, Jefferys JGR, Worrell G, Schulze-Bonhage A, Joshi RB, Jirsa V, Goodfellow M, Meisel C, Lehnertz K. Seizure. 2020 May; 2020 Mar 19. PMID: 32272333.
- Assessment of the Predictive Value of Outpatient Smartphone Videos for Diagnosis of Epileptic Seizures.Tatum WO, Hirsch LJ, Gelfand MA, Acton EK, LaFrance WC Jr, Duckrow RB, Chen DK, Blum AS, Hixson JD, Drazkowski JF, Benbadis SR, Cascino GD. JAMA Neurol. 2020 May 1. PMID: 31961382.
- Deficiency of FRAS1-related extracellular matrix 1 (FREM1) causes congenital diaphragmatic hernia in humans and mice.Beck TF, Veenma D, Shchelochkov OA, Yu Z, Kim BJ, Zaveri HP, van Bever Y, Choi S, Douben H, Bertin TK, Patel PI, Lee B, Tibboel D, de Klein A, Stockton DW, Justice MJ, Scott DA. Hum Mol Genet. 2020 Apr 15. PMID: 32016392.
- Epilepsy Benchmarks Area II: Prevent Epilepsy and Its Progression.Binder DK, Boison D, Eid T, Frankel WN, Mingorance A, Smith BN, Dacks PA, Whittemore V, Poduri A. Epilepsy Curr. 2020 Jan-Feb; 2020 Jan 15. PMID: 31937124.
- An Ancient Enzyme Takes a Hit in Epilepsy.Eid T. Epilepsy Curr. 2019 Nov-Dec; 2019 Sep 17. PMID: 31530017.
- Default mode and visual network activity in an attention task: Direct measurement with intracranial EEG.Li J, Kronemer SI, Herman WX, Kwon H, Ryu JH, Micek C, Wu Y, Gerrard J, Spencer DD, Blumenfeld H. Neuroimage. 2019 Nov 1; 2019 Jul 8. PMID: 31295566.
- Astrocytes and Glutamine Synthetase in Epileptogenesis.Eid T, Lee TW, Patrylo P, Zaveri HP. J Neurosci Res. 2019 Nov; 2018 Jul 18. PMID: 30022509.
- Branched-Chain Amino Acids and Seizures: A Systematic Review of the Literature.Gruenbaum SE, Chen EC, Sandhu MRS, Deshpande K, Dhaher R, Hersey D, Eid T. CNS Drugs. 2019 Aug. PMID: 31313139.
- Slowly progressive fatal PML-IRIS following antiretroviral initiation at CD4+ nadir of 350 cells/mm(3) despite CD4+ cell count rise to 900 cells/mm(3).Sandhu MR, Rutledge R, Grant M, Mahajan A, Spudich S. Int J STD AIDS. 2019 Jul; 2019 May 2. PMID: 31046614.
- Slowing less than 1 Hz is decreased near the seizure onset zone.Lundstrom BN, Boly M, Duckrow R, Zaveri HP, Blumenfeld H. Sci Rep. 2019 Apr 17; 2019 Apr 17. PMID: 30996228.
- Human and rodent temporal lobe epilepsy is characterized by changes in O-GlcNAc homeostasis that can be reversed to dampen epileptiform activity.Sánchez RG, Parrish RR, Rich M, Webb WM, Lockhart RM, Nakao K, Ianov L, Buckingham SC, Broadwater DR, Jenkins A, de Lanerolle NC, Cunningham M, Eid T, Riley K, Lubin FD. Neurobiol Dis. 2019 Apr; 2019 Jan 6. PMID: 30625365.
- Association of Seizure Spread With Surgical Failure in Epilepsy.Andrews JP, Gummadavelli A, Farooque P, Bonito J, Arencibia C, Blumenfeld H, Spencer DD. JAMA Neurol. 2019 Apr 1. PMID: 30508033.
- Effects of Branched-Chain Amino Acid Supplementation on Spontaneous Seizures and Neuronal Viability in a Model of Mesial Temporal Lobe Epilepsy.Gruenbaum SE, Dhaher R, Rapuano A, Zaveri HP, Tang A, de Lanerolle N, Eid T. J Neurosurg Anesthesiol. 2019 Apr. PMID: 29620688.
- Resting state connectivity in neocortical epilepsy: The epilepsy network as a patient-specific biomarker.Marino AC, Yang GJ, Tyrtova E, Wu K, Zaveri HP, Farooque P, Spencer DD, Bandt SK. Clin Neurophysiol. 2019 Feb; 2018 Dec 6. PMID: 30605890.
- Selective deletion of glutamine synthetase in the mouse cerebral cortex induces glial dysfunction and vascular impairment that precede epilepsy and neurodegeneration.Zhou Y, Dhaher R, Parent M, Hu QX, Hassel B, Yee SP, Hyder F, Gruenbaum SE, Eid T, Danbolt NC. Neurochem Int. 2019 Feb; 2018 Jul 24. PMID: 30053506.
- Axon-terminals expressing EAAT2 (GLT-1; Slc1a2) are common in the forebrain and not limited to the hippocampus.Zhou Y, Hassel B, Eid T, Danbolt NC. Neurochem Int. 2019 Feb; 2018 Mar 9. PMID: 29530756.
- A Switch and Wave of Neuronal Activity in the Cerebral Cortex During the First Second of Conscious Perception.Herman WX, Smith RE, Kronemer SI, Watsky RE, Chen WC, Gober LM, Touloumes GJ, Khosla M, Raja A, Horien CL, Morse EC, Botta KL, Hirsch LJ, Alkawadri R, Gerrard JL, Spencer DD, Blumenfeld H. Cereb Cortex. 2019 Feb 1. PMID: 29194517.
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