Main Scientific Publications

Interneuron loss and microglia activation by transcriptome analyses in the basal ganglia of Tourette disorder.Wang Y, Fasching L, Wu F, Suvakov M, Huttner A, Berretta S, Roberts R, Leckman JF, Fernandez TV, Abyzov A, Vaccarino FM. Biol Psychiatry. 2025 Jan 30; 2025 Jan 30. PMID: 39892689.
A framework for neural organoids, assembloids and transplantation studies.Pașca SP, Arlotta P, Bateup HS, Camp JG, Cappello S, Gage FH, Knoblich JA, Kriegstein AR, Lancaster MA, Ming GL, Novarino G, Okano H, Parmar M, Park IH, Reiner O, Song H, Studer L, Takahashi J, Temple S, Testa G, Treutlein B, Vaccarino FM, Vanderhaeghen P, Young-Pearse T. Nature. 2024 Dec 9; 2024 Dec 9. PMID: 39653126.
Elevated antibody binding to striatal cholinergic interneurons in patients with pediatric acute-onset neuropsychiatric syndrome.Xu J, Frankovich J, Liu RJ, Thienemann M, Silverman M, Farhadian B, Willett T, Manko C, Columbo L, Leibold C, Vaccarino FM, Che A, Pittenger C. Brain Behav Immun. 2024 Nov; 2024 Jul 30. PMID: 39084540.
Transgenerational transmission of post-zygotic mutations suggests symmetric contribution of first two blastomeres to human germline.Jang Y, Tomasini L, Bae T, Szekely A, Vaccarino FM, Abyzov A. Nat Commun. 2024 Oct 23; 2024 Oct 23. PMID: 39438473.
Early Developmental Origins of Cortical Disorders Modeled in Human Neural Stem Cells.Mato-Blanco X, Kim SK, Jourdon A, Ma S, Tebbenkamp ATN, Liu F, Duque A, Vaccarino FM, Sestan N, Colantuoni C, Rakic P, Santpere G, Micali N. bioRxiv. 2024 Jun 14; 2024 Jun 14. PMID: 38915580.
Massively parallel characterization of regulatory elements in the developing human cortex.Deng C, Whalen S, Steyert M, Ziffra R, Przytycki PF, Inoue F, Pereira DA, Capauto D, Norton S, Vaccarino FM, Pollen AA, Nowakowski TJ, Ahituv N, Pollard KS. Science. 2024 May 24; 2024 May 24. PMID: 38781390.
Evaluating performance and applications of sample-wise cell deconvolution methods on human brain transcriptomic data.Dai R, Chu T, Zhang M, Wang X, Jourdon A, Wu F, Mariani J, Vaccarino FM, Lee D, Fullard JF, Hoffman GE, Roussos P, Wang Y, Wang X, Pinto D, Wang SH, Zhang C, Chen C, Liu C. Sci Adv. 2024 May 24; 2024 May 23. PMID: 38781336.
Specification of human regional brain lineages using orthogonal gradients of WNT and SHH in organoids.Scuderi S, Kang TY, Jourdon A, Yang L, Wu F, Nelson A, Anderson GM, Mariani J, Sarangi V, Abyzov A, Levchenko A, Vaccarino FM. bioRxiv. 2024 May 19; 2024 May 19. PMID: 38798404.
Characterization of enhancer activity in early human neurodevelopment using Massively Parallel Reporter Assay (MPRA) and forebrain organoids.Capauto D, Wang Y, Wu F, Norton S, Mariani J, Inoue F, Crawford GE, Ahituv N, Abyzov A, Vaccarino FM. Sci Rep. 2024 Feb 16; 2024 Feb 16. PMID: 38365907.
Genomic data resources of the Brain Somatic Mosaicism Network for neuropsychiatric diseases.Garrison MA, Jang Y, Bae T, Cherskov A, Emery SB, Fasching L, Jones A, Moldovan JB, Molitor C, Pochareddy S, Peters MA, Shin JH, Wang Y, Yang X, Akbarian S, Chess A, Gage FH, Gleeson JG, Kidd JM, McConnell M, Mills RE, Moran JV, Park PJ, Sestan N, Urban AE, Vaccarino FM, Walsh CA, Weinberger DR, Wheelan SJ, Abyzov A. Sci Data. 2023 Nov 20; 2023 Nov 20. PMID: 37985666.
Author Correction: Modeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis.Jourdon A, Wu F, Mariani J, Capauto D, Norton S, Tomasini L, Amiri A, Suvakov M, Schreiner JD, Jang Y, Panda A, Nguyen CK, Cummings EM, Han G, Powell K, Szekely A, McPartland JC, Pelphrey K, Chawarska K, Ventola P, Abyzov A, Vaccarino FM. Nat Neurosci. 2023 Nov. PMID: 37674007.
Author Correction: Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia.Zhu X, Zhou B, Pattni R, Gleason K, Tan C, Kalinowski A, Sloan S, Fiston-Lavier AS, Mariani J, Petrov D, Barres BA, Duncan L, Abyzov A, Vogel H, Moran JV, Vaccarino FM, Tamminga CA, Levinson DF, Urban AE. Nat Neurosci. 2023 Oct. PMID: 37648813.
Modeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis.Jourdon A, Wu F, Mariani J, Capauto D, Norton S, Tomasini L, Amiri A, Suvakov M, Schreiner JD, Jang Y, Panda A, Nguyen CK, Cummings EM, Han G, Powell K, Szekely A, McPartland JC, Pelphrey K, Chawarska K, Ventola P, Abyzov A, Vaccarino FM. Nat Neurosci. 2023 Sep; 2023 Aug 10. PMID: 37563294.
Characterization of enhancer activity in early human neurodevelopment using Massively parallel reporter assay (MPRA) and forebrain organoids.Capauto D, Wang Y, Wu F, Norton S, Mariani J, Inoue F, Crawford GE, Ahituv N, Abyzov A, Vaccarino FM. bioRxiv. 2023 Aug 14; 2023 Aug 14. PMID: 37645832.
Efficient reconstruction of cell lineage trees for cell ancestry and cancer.Jang Y, Fasching L, Bae T, Tomasini L, Schreiner J, Szekely A, Fernandez TV, Leckman JF, Vaccarino FM, Abyzov A. Nucleic Acids Res. 2023 Jun 9. PMID: 37026484.
Clonally Selected Lines After CRISPR-Cas Editing Are Not Isogenic.Panda A, Suvakov M, Mariani J, Drucker KL, Park Y, Jang Y, Kollmeyer TM, Sarkar G, Bae T, Kim JJ, Yoon WH, Jenkins RB, Vaccarino FM, Abyzov A. CRISPR J. 2023 Apr. PMID: 37071670.
Maternal FGF2 levels associated with child anxiety and depression symptoms through child FGF2 levels.Lebowitz ER, Marin CE, Orbach M, Salmaso N, Vaccarino FM, Silverman WK. J Affect Disord. 2023 Apr 1; 2023 Jan 28. PMID: 36717031.
Evaluating performance and applications of sample-wise cell deconvolution methods on human brain transcriptomic data.Dai R, Chu T, Zhang M, Wang X, Jourdon A, Wu F, Mariani J, Vaccarino FM, Lee D, Fullard JF, Hoffman GE, Roussos P, Wang Y, Wang X, Pinto D, Wang SH, Zhang C, Chen C, Liu C. bioRxiv. 2023 Mar 15; 2023 Mar 15. PMID: 36993743.
Neonatal loss of FGFR2 in astroglial cells affects locomotion, sociability, working memory, and glia-neuron interactions in mice.Stevens HE, Scuderi S, Collica SC, Tomasi S, Horvath TL, Vaccarino FM. Transl Psychiatry. 2023 Mar 11; 2023 Mar 11. PMID: 36906620.
Massively parallel characterization of psychiatric disorder-associated and cell-type-specific regulatory elements in the developing human cortex.Deng C, Whalen S, Steyert M, Ziffra R, Przytycki PF, Inoue F, Pereira DA, Capauto D, Norton S, Vaccarino FM, Pollen A, Nowakowski TJ, Ahituv N, Pollard KS. bioRxiv. 2023 Feb 16; 2023 Feb 16. PMID: 36824845.
Characterization of human basal ganglia organoids.Brady MV, Mariani J, Koca Y, Szekely A, King RA, Bloch MH, Landeros-Weisenberger A, Leckman JF, Vaccarino FM. Mol Psychiatry. 2022 Dec. PMID: 36536052.
Somatic genomic mosaicism in the brain during aging: Scratching the surface.Bae T, Wang Y, Vaccarino FM, Abyzov A. Clin Transl Med. 2022 Dec. PMID: 36495113.
Mispatterning and interneuron deficit in Tourette Syndrome basal ganglia organoids.Brady MV, Mariani J, Koca Y, Szekely A, King RA, Bloch MH, Landeros-Weisenberger A, Leckman JF, Vaccarino FM. Mol Psychiatry. 2022 Dec; 2022 Nov 29. PMID: 36447010.
A nomenclature consensus for nervous system organoids and assembloids.Pașca SP, Arlotta P, Bateup HS, Camp JG, Cappello S, Gage FH, Knoblich JA, Kriegstein AR, Lancaster MA, Ming GL, Muotri AR, Park IH, Reiner O, Song H, Studer L, Temple S, Testa G, Treutlein B, Vaccarino FM. Nature. 2022 Sep; 2022 Sep 28. PMID: 36171373.
Analysis of somatic mutations in 131 human brains reveals aging-associated hypermutability.Bae T, Fasching L, Wang Y, Shin JH, Suvakov M, Jang Y, Norton S, Dias C, Mariani J, Jourdon A, Wu F, Panda A, Pattni R, Chahine Y, Yeh R, Roberts RC, Huttner A, Kleinman JE, Hyde TM, Straub RE, Walsh CA, Urban AE, Leckman JF, Weinberger DR, Vaccarino FM, Abyzov A. Science. 2022 Jul 29; 2022 Jul 28. PMID: 35901164.
All2: A tool for selecting mosaic mutations from comprehensive multi-cell comparisons.Sarangi V, Jang Y, Suvakov M, Bae T, Fasching L, Sekar S, Tomasini L, Mariani J, Vaccarino FM, Abyzov A. PLoS Comput Biol. 2022 Apr; 2022 Apr 20. PMID: 35442945.
Role of SHH in Patterning Human Pluripotent Cells towards Ventral Forebrain Fates.Brady MV, Vaccarino FM. Cells. 2021 Apr 16; 2021 Apr 16. PMID: 33923415.
Comprehensive identification of somatic nucleotide variants in human brain tissue.Wang Y, Bae T, Thorpe J, Sherman MA, Jones AG, Cho S, Daily K, Dou Y, Ganz J, Galor A, Lobon I, Pattni R, Rosenbluh C, Tomasi S, Tomasini L, Yang X, Zhou B, Akbarian S, Ball LL, Bizzotto S, Emery SB, Doan R, Fasching L, Jang Y, Juan D, Lizano E, Luquette LJ, Moldovan JB, Narurkar R, Oetjens MT, Rodin RE, Sekar S, Shin JH, Soriano E, Straub RE, Zhou W, Chess A, Gleeson JG, Marquès-Bonet T, Park PJ, Peters MA, Pevsner J, Walsh CA, Weinberger DR, Vaccarino FM, Moran JV, Urban AE, Kidd JM, Mills RE, Abyzov A. Genome Biol. 2021 Mar 29; 2021 Mar 29. PMID: 33781308.
Early developmental asymmetries in cell lineage trees in living individuals.Fasching L, Jang Y, Tomasi S, Schreiner J, Tomasini L, Brady MV, Bae T, Sarangi V, Vasmatzis N, Wang Y, Szekely A, Fernandez TV, Leckman JF, Abyzov A, Vaccarino FM. Science. 2021 Mar 19. PMID: 33737484.
Fibroblast Growth Factor 2 Implicated in Childhood Anxiety and Depression Symptoms.Lebowitz ER, Orbach M, Marin CE, Salmaso N, Vaccarino FM, Silverman WK. J Affect Disord. 2021 Mar 1; 2021 Jan 11. PMID: 33445083.
Cell-to-Cell Adhesion and Neurogenesis in Human Cortical Development: A Study Comparing 2D Monolayers with 3D Organoid Cultures.Scuderi S, Altobelli GG, Cimini V, Coppola G, Vaccarino FM. Stem Cell Reports. 2021 Feb 9; 2021 Jan 28. PMID: 33513360.
Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia.Zhu X, Zhou B, Pattni R, Gleason K, Tan C, Kalinowski A, Sloan S, Fiston-Lavier AS, Mariani J, Petrov D, Barres BA, Duncan L, Abyzov A, Vogel H, Moran JV, Vaccarino FM, Tamminga CA, Levinson DF, Urban AE. Nat Neurosci. 2021 Feb; 2021 Jan 11. PMID: 33432196.
PsychENCODE and beyond: transcriptomics and epigenomics of brain development and organoids.Jourdon A, Scuderi S, Capauto D, Abyzov A, Vaccarino FM. Neuropsychopharmacology. 2021 Jan; 2020 Jul 13. PMID: 32659782.
Antibodies From Children With PANDAS Bind Specifically to Striatal Cholinergic Interneurons and Alter Their Activity.Xu J, Liu RJ, Fahey S, Frick L, Leckman J, Vaccarino F, Duman RS, Williams K, Swedo S, Pittenger C. Am J Psychiatry. 2021 Jan 1; 2020 Jun 16. PMID: 32539528.
Complex mosaic structural variations in human fetal brains.Sekar S, Tomasini L, Proukakis C, Bae T, Manlove L, Jang Y, Scuderi S, Zhou B, Kalyva M, Amiri A, Mariani J, Sedlazeck FJ, Urban AE, Vaccarino FM, Abyzov A. Genome Res. 2020 Dec; 2020 Oct 29. PMID: 33122304.
The role of somatic mosaicism in brain disease.Jourdon A, Fasching L, Scuderi S, Abyzov A, Vaccarino FM. Curr Opin Genet Dev. 2020 Dec; 2020 Jul 1. PMID: 32622340.
SCELLECTOR: ranking amplification bias in single cells using shallow sequencing.Sarangi V, Jourdon A, Bae T, Panda A, Vaccarino F, Abyzov A. BMC Bioinformatics. 2020 Nov 12; 2020 Nov 12. PMID: 33183232.
Cell Lineage Tracing and Cellular Diversity in Humans.Abyzov A, Vaccarino FM. Annu Rev Genomics Hum Genet. 2020 Aug 31; 2020 May 15. PMID: 32413272.
One for All: A Pooled Approach to Classify Functional Impacts of Multiple Mutations.Jourdon A, Vaccarino FM. Cell Stem Cell. 2020 Jul 2. PMID: 32619508.
Breakthrough Moments: Yoshiki Sasai's Discoveries in the Third Dimension.Mariani J, Vaccarino FM. Cell Stem Cell. 2019 Jun 6. PMID: 31173711.
Transcriptome and epigenome landscape of human cortical development modeled in organoids.Amiri A, Coppola G, Scuderi S, Wu F, Roychowdhury T, Liu F, Pochareddy S, Shin Y, Safi A, Song L, Zhu Y, Sousa AMM, Gerstein M, Crawford GE, Sestan N, Abyzov A, Vaccarino FM. Science. 2018 Dec 14. PMID: 30545853.
Fibroblast growth factor 2 is necessary for the antidepressant effects of fluoxetine.Simard S, Shail P, MacGregor J, El Sayed M, Duman RS, Vaccarino FM, Salmaso N. PLoS One. 2018; 2018 Oct 1. PMID: 30273396.
Loss of TrkB Signaling in Parvalbumin-Expressing Basket Cells Results in Network Activity Disruption and Abnormal Behavior.Xenos D, Kamceva M, Tomasi S, Cardin JA, Schwartz ML, Vaccarino FM. Cereb Cortex. 2018 Oct 1. PMID: 28968898.
iPSC-derived neurons profiling reveals GABAergic circuit disruption and acetylated α-tubulin defect which improves after iHDAC6 treatment in Rett syndrome.Landucci E, Brindisi M, Bianciardi L, Catania LM, Daga S, Croci S, Frullanti E, Fallerini C, Butini S, Brogi S, Furini S, Melani R, Molinaro A, Lorenzetti FC, Imperatore V, Amabile S, Mariani J, Mari F, Ariani F, Pizzorusso T, Pinto AM, Vaccarino FM, Renieri A, Campiani G, Meloni I. Exp Cell Res. 2018 Jul 15; 2018 May 4. PMID: 29730163.
Different mutational rates and mechanisms in human cells at pregastrulation and neurogenesis.Bae T, Tomasini L, Mariani J, Zhou B, Roychowdhury T, Franjic D, Pletikos M, Pattni R, Chen BJ, Venturini E, Riley-Gillis B, Sestan N, Urban AE, Abyzov A, Vaccarino FM. Science. 2018 Feb 2; 2017 Dec 7. PMID: 29217587.
Human induced pluripotent stem cells for modelling neurodevelopmental disorders.Ardhanareeswaran K, Mariani J, Coppola G, Abyzov A, Vaccarino FM. Nat Rev Neurol. 2017 May; 2017 Apr 18. PMID: 28418023.
Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network.McConnell MJ, Moran JV, Abyzov A, Akbarian S, Bae T, Cortes-Ciriano I, Erwin JA, Fasching L, Flasch DA, Freed D, Ganz J, Jaffe AE, Kwan KY, Kwon M, Lodato MA, Mills RE, Paquola ACM, Rodin RE, Rosenbluh C, Sestan N, Sherman MA, Shin JH, Song S, Straub RE, Thorpe J, Weinberger DR, Urban AE, Zhou B, Gage FH, Lehner T, Senthil G, Walsh CA, Chess A, Courchesne E, Gleeson JG, Kidd JM, Park PJ, Pevsner J, Vaccarino FM. Science. 2017 Apr 28; 2017 Apr 27. PMID: 28450582.
One thousand somatic SNVs per skin fibroblast cell set baseline of mosaic mutational load with patterns that suggest proliferative origin.Abyzov A, Tomasini L, Zhou B, Vasmatzis N, Coppola G, Amenduni M, Pattni R, Wilson M, Gerstein M, Weissman S, Urban AE, Vaccarino FM. Genome Res. 2017 Apr; 2017 Feb 24. PMID: 28235832.
Fibroblast Growth Factor 2 Modulates Hypothalamic Pituitary Axis Activity and Anxiety Behavior Through Glucocorticoid Receptors.Salmaso N, Stevens HE, McNeill J, ElSayed M, Ren Q, Maragnoli ME, Schwartz ML, Tomasi S, Sapolsky RM, Duman R, Vaccarino FM. Biol Psychiatry. 2016 Sep 15; 2016 Mar 2. PMID: 27133954.
Altering the course of schizophrenia: progress and perspectives.Millan MJ, Andrieux A, Bartzokis G, Cadenhead K, Dazzan P, Fusar-Poli P, Gallinat J, Giedd J, Grayson DR, Heinrichs M, Kahn R, Krebs MO, Leboyer M, Lewis D, Marin O, Marin P, Meyer-Lindenberg A, McGorry P, McGuire P, Owen MJ, Patterson P, Sawa A, Spedding M, Uhlhaas P, Vaccarino F, Wahlestedt C, Weinberger D. Nat Rev Drug Discov. 2016 Jul; 2016 Mar 4. PMID: 26939910.
Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating.Zhang Y, Zhang XF, Fleming MR, Amiri A, El-Hassar L, Surguchev AA, Hyland C, Jenkins DP, Desai R, Brown MR, Gazula VR, Waters MF, Large CH, Horvath TL, Navaratnam D, Vaccarino FM, Forscher P, Kaczmarek LK. Cell. 2016 Apr 7; 2016 Mar 17. PMID: 26997484.
Transcriptome Analysis of the Human Striatum in Tourette Syndrome.Lennington JB, Coppola G, Kataoka-Sasaki Y, Fernandez TV, Palejev D, Li Y, Huttner A, Pletikos M, Sestan N, Leckman JF, Vaccarino FM. Biol Psychiatry. 2016 Mar 1; 2014 Jul 24. PMID: 25199956.
Altered expression of neuropeptides in FoxG1-null heterozygous mutant mice.Frullanti E, Amabile S, Lolli MG, Bartolini A, Livide G, Landucci E, Mari F, Vaccarino FM, Ariani F, Massimino L, Renieri A, Meloni I. Eur J Hum Genet. 2016 Feb; 2015 May 13. PMID: 25966633.
Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders.Brennand KJ, Marchetto MC, Benvenisty N, Brüstle O, Ebert A, Izpisua Belmonte JC, Kaykas A, Lancaster MA, Livesey FJ, McConnell MJ, McKay RD, Morrow EM, Muotri AR, Panchision DM, Rubin LL, Sawa A, Soldner F, Song H, Studer L, Temple S, Vaccarino FM, Wu J, Vanderhaeghen P, Gage FH, Jaenisch R. Stem Cell Reports. 2015 Dec 8; 2015 Nov 21. PMID: 26610635.
The PsychENCODE project.Akbarian S, Liu C, Knowles JA, Vaccarino FM, Farnham PJ, Crawford GE, Jaffe AE, Pinto D, Dracheva S, Geschwind DH, Mill J, Nairn AC, Abyzov A, Pochareddy S, Prabhakar S, Weissman S, Sullivan PF, State MW, Weng Z, Peters MA, White KP, Gerstein MB, Amiri A, Armoskus C, Ashley-Koch AE, Bae T, Beckel-Mitchener A, Berman BP, Coetzee GA, Coppola G, Francoeur N, Fromer M, Gao R, Grennan K, Herstein J, Kavanagh DH, Ivanov NA, Jiang Y, Kitchen RR, Kozlenkov A, Kundakovic M, Li M, Li Z, Liu S, Mangravite LM, Mattei E, Markenscoff-Papadimitriou E, Navarro FC, North N, Omberg L, Panchision D, Parikshak N, Poschmann J, Price AJ, Purcaro M, Reddy TE, Roussos P, Schreiner S, Scuderi S, Sebra R, Shibata M, Shieh AW, Skarica M, Sun W, Swarup V, Thomas A, Tsuji J, van Bakel H, Wang D, Wang Y, Wang K, Werling DM, Willsey AJ, Witt H, Won H, Wong CC, Wray GA, Wu EY, Xu X, Yao L, Senthil G, Lehner T, Sklar P, Sestan N. Nat Neurosci. 2015 Dec. PMID: 26605881.
Contribution of maternal oxygenic state to the effects of chronic postnatal hypoxia on mouse body and brain development.Salmaso N, Dominguez M, Kravitz J, Komitova M, Vaccarino FM, Schwartz ML. Neurosci Lett. 2015 Sep 14; 2015 Jul 26. PMID: 26222256.
Editorial commentary: "What does immunology have to do with brain development and neuropsychiatric disorders?".Leckman JF, Vaccarino FM. Brain Res. 2015 Aug 18; 2014 Oct 8. PMID: 25283746.
FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders.Mariani J, Coppola G, Zhang P, Abyzov A, Provini L, Tomasini L, Amenduni M, Szekely A, Palejev D, Wilson M, Gerstein M, Grigorenko EL, Chawarska K, Pelphrey KA, Howe JR, Vaccarino FM. Cell. 2015 Jul 16. PMID: 26186191.
How animal models inform child and adolescent psychiatry.Stevens HE, Vaccarino FM. J Am Acad Child Adolesc Psychiatry. 2015 May; 2015 Feb 12. PMID: 25901771.
The use of stem cells to study autism spectrum disorder.Ardhanareeswaran K, Coppola G, Vaccarino F. Yale J Biol Med. 2015 Mar; 2015 Mar 4. PMID: 25745370.
Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome.Xu M, Kobets A, Du JC, Lennington J, Li L, Banasr M, Duman RS, Vaccarino FM, DiLeone RJ, Pittenger C. Proc Natl Acad Sci U S A. 2015 Jan 20; 2015 Jan 5. PMID: 25561540.
Fgfr1 inactivation in the mouse telencephalon results in impaired maturation of interneurons expressing parvalbumin.Smith KM, Maragnoli ME, Phull PM, Tran KM, Choubey L, Vaccarino FM. PLoS One. 2014; 2014 Aug 12. PMID: 25116473.
Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding.Kim JG, Suyama S, Koch M, Jin S, Argente-Arizon P, Argente J, Liu ZW, Zimmer MR, Jeong JK, Szigeti-Buck K, Gao Y, Garcia-Caceres C, Yi CX, Salmaso N, Vaccarino FM, Chowen J, Diano S, Dietrich MO, Tschöp MH, Horvath TL. Nat Neurosci. 2014 Jul; 2014 Jun 1. PMID: 24880214.
Neurobiology of premature brain injury.Salmaso N, Jablonska B, Scafidi J, Vaccarino FM, Gallo V. Nat Neurosci. 2014 Mar; 2014 Feb 25. PMID: 24569830.
Neurogenesis and maturation in neonatal brain injury.Salmaso N, Tomasi S, Vaccarino FM. Clin Perinatol. 2014 Mar; 2013 Dec 15. PMID: 24524457.
Hypoxia-induced developmental delays of inhibitory interneurons are reversed by environmental enrichment in the postnatal mouse forebrain.Komitova M, Xenos D, Salmaso N, Tran KM, Brand T, Schwartz ML, Ment L, Vaccarino FM. J Neurosci. 2013 Aug 14. PMID: 23946395.
Functional genomic screen of human stem cell differentiation reveals pathways involved in neurodevelopment and neurodegeneration.Zhang Y, Schulz VP, Reed BD, Wang Z, Pan X, Mariani J, Euskirchen G, Snyder MP, Vaccarino FM, Ivanova N, Weissman SM, Szekely AM. Proc Natl Acad Sci U S A. 2013 Jul 23; 2013 Jul 8. PMID: 23836664.
Cortical gyrification induced by fibroblast growth factor 2 in the mouse brain.Rash BG, Tomasi S, Lim HD, Suh CY, Vaccarino FM. J Neurosci. 2013 Jun 26. PMID: 23804101.
Prenatal stress delays inhibitory neuron progenitor migration in the developing neocortex.Stevens HE, Su T, Yanagawa Y, Vaccarino FM. Psychoneuroendocrinology. 2013 Apr; 2012 Aug 19. PMID: 22910687.
Somatic copy number mosaicism in human skin revealed by induced pluripotent stem cells.Abyzov A, Mariani J, Palejev D, Zhang Y, Haney MS, Tomasini L, Ferrandino AF, Rosenberg Belmaker LA, Szekely A, Wilson M, Kocabas A, Calixto NE, Grigorenko EL, Huttner A, Chawarska K, Weissman S, Urban AE, Gerstein M, Vaccarino FM. Nature. 2012 Dec 20; 2012 Nov 18. PMID: 23160490.
Neurobiology meets genomic science: the promise of human-induced pluripotent stem cells.Stevens HE, Mariani J, Coppola G, Vaccarino FM. Dev Psychopathol. 2012 Nov. PMID: 23062309.
Age-related changes of gene expression in the neocortex: preliminary data on RNA-Seq of the transcriptome in three functionally distinct cortical areas.Naumova OY, Palejev D, Vlasova NV, Lee M, Rychkov SY, Babich ON, M Vaccarino F, Grigorenko EL. Dev Psychopathol. 2012 Nov. PMID: 23062308.
Oligodendrocyte regeneration after neonatal hypoxia requires FoxO1-mediated p27Kip1 expression.Jablonska B, Scafidi J, Aguirre A, Vaccarino F, Nguyen V, Borok E, Horvath TL, Rowitch DH, Gallo V. J Neurosci. 2012 Oct 17. PMID: 23077062.
Modeling human cortical development in vitro using induced pluripotent stem cells.Mariani J, Simonini MV, Palejev D, Tomasini L, Coppola G, Szekely AM, Horvath TL, Vaccarino FM. Proc Natl Acad Sci U S A. 2012 Jul 31; 2012 Jul 3. PMID: 22761314.
Environmental enrichment increases the GFAP+ stem cell pool and reverses hypoxia-induced cognitive deficits in juvenile mice.Salmaso N, Silbereis J, Komitova M, Mitchell P, Chapman K, Ment LR, Schwartz ML, Vaccarino FM. J Neurosci. 2012 Jun 27. PMID: 22745493.
Impaired motor coordination and disrupted cerebellar architecture in Fgfr1 and Fgfr2 double knockout mice.Müller Smith K, Williamson TL, Schwartz ML, Vaccarino FM. Brain Res. 2012 Jun 15; 2012 Apr 11. PMID: 22578469.
Learning and memory depend on fibroblast growth factor receptor 2 functioning in hippocampus.Stevens HE, Jiang GY, Schwartz ML, Vaccarino FM. Biol Psychiatry. 2012 Jun 15; 2012 Apr 27. PMID: 22541947.
FGF signaling expands embryonic cortical surface area by regulating Notch-dependent neurogenesis.Rash BG, Lim HD, Breunig JJ, Vaccarino FM. J Neurosci. 2011 Oct 26. PMID: 22031906.
Cortical glial fibrillary acidic protein-positive cells generate neurons after perinatal hypoxic injury.Bi B, Salmaso N, Komitova M, Simonini MV, Silbereis J, Cheng E, Kim J, Luft S, Ment LR, Horvath TL, Schwartz ML, Vaccarino FM. J Neurosci. 2011 Jun 22. PMID: 21697371.
Induced pluripotent stem cells: a new tool to confront the challenge of neuropsychiatric disorders.Vaccarino FM, Stevens HE, Kocabas A, Palejev D, Szekely A, Grigorenko EL, Weissman S. Neuropharmacology. 2011 Jun; 2011 Mar 1. PMID: 21371482.
Annual Research Review: The promise of stem cell research for neuropsychiatric disorders.Vaccarino FM, Urban AE, Stevens HE, Szekely A, Abyzov A, Grigorenko EL, Gerstein M, Weissman S. J Child Psychol Psychiatry. 2011 Apr; 2011 Jan 4. PMID: 21204834.
Toward a novel endogenous anxiolytic factor, fibroblast growth factor 2.Salmaso N, Vaccarino FM. Biol Psychiatry. 2011 Mar 15. PMID: 21353835.
Pyramidal neurons are generated from oligodendroglial progenitor cells in adult piriform cortex.Guo F, Maeda Y, Ma J, Xu J, Horiuchi M, Miers L, Vaccarino F, Pleasure D. J Neurosci. 2010 Sep 8. PMID: 20826667.
Neural stem cell regulation, fibroblast growth factors, and the developmental origins of neuropsychiatric disorders.Stevens HE, Smith KM, Rash BG, Vaccarino FM. Front Neurosci. 2010; 2010 Sep 1. PMID: 20877431.
Astroglial cells in the external granular layer are precursors of cerebellar granule neurons in neonates.Silbereis J, Heintz T, Taylor MM, Ganat Y, Ment LR, Bordey A, Vaccarino F. Mol Cell Neurosci. 2010 Aug; 2010 May 12. PMID: 20470892.
Fgfr2 is required for the development of the medial prefrontal cortex and its connections with limbic circuits.Stevens HE, Smith KM, Maragnoli ME, Fagel D, Borok E, Shanabrough M, Horvath TL, Vaccarino FM. J Neurosci. 2010 Apr 21. PMID: 20410112.
Decreased number of parvalbumin and cholinergic interneurons in the striatum of individuals with Tourette syndrome.Kataoka Y, Kalanithi PS, Grantz H, Schwartz ML, Saper C, Leckman JF, Vaccarino FM. J Comp Neurol. 2010 Feb 1. PMID: 19941350.
Exciting news from the adult mouse subventricular zone.Komitova M, Vaccarino FM. Front Neurosci. 2010; 2010 Jan 27. PMID: 20582263.
Modeling premature brain injury and recovery.Scafidi J, Fagel DM, Ment LR, Vaccarino FM. Int J Dev Neurosci. 2009 Dec; 2009 May 29. PMID: 19482072.
Hypoxic injury during neonatal development in murine brain: correlation between in vivo DTI findings and behavioral assessment.Chahboune H, Ment LR, Stewart WB, Rothman DL, Vaccarino FM, Hyder F, Schwartz ML. Cereb Cortex. 2009 Dec; 2009 Apr 20. PMID: 19380380.
Increased brain size in autism--what it will take to solve a mystery.Vaccarino FM, Smith KM. Biol Psychiatry. 2009 Aug 15. PMID: 19643218.
Precursors with glial fibrillary acidic protein promoter activity transiently generate GABA interneurons in the postnatal cerebellum.Silbereis J, Cheng E, Ganat YM, Ment LR, Vaccarino FM. Stem Cells. 2009 May. PMID: 19418461.
Regulation of cerebral cortical size and neuron number by fibroblast growth factors: implications for autism.Vaccarino FM, Grigorenko EL, Smith KM, Stevens HE. J Autism Dev Disord. 2009 Mar; 2008 Oct 13. PMID: 18850329.
Fgfr1 is required for cortical regeneration and repair after perinatal hypoxia.Fagel DM, Ganat Y, Cheng E, Silbereis J, Ohkubo Y, Ment LR, Vaccarino FM. J Neurosci. 2009 Jan 28. PMID: 19176828.
Decrease in excitatory neurons, astrocytes and proliferating progenitors in the cerebral cortex of mice lacking exon 3 from the Fgf2 gene.Chen K, Ohkubo Y, Shin D, Doetschman T, Sanford LP, Li H, Vaccarino FM. BMC Neurosci. 2008 Sep 30; 2008 Sep 30. PMID: 18826624.
Deficiency in inhibitory cortical interneurons associates with hyperactivity in fibroblast growth factor receptor 1 mutant mice.Müller Smith K, Fagel DM, Stevens HE, Rabenstein RL, Maragnoli ME, Ohkubo Y, Picciotto MR, Schwartz ML, Vaccarino FM. Biol Psychiatry. 2008 May 15; 2007 Nov 7. PMID: 17988653.
Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus.Breunig JJ, Silbereis J, Vaccarino FM, Sestan N, Rakic P. Proc Natl Acad Sci U S A. 2007 Dec 18; 2007 Dec 11. PMID: 18077357.
Astroglial cells in development, regeneration, and repair.Vaccarino FM, Fagel DM, Ganat Y, Maragnoli ME, Ment LR, Ohkubo Y, Schwartz ML, Silbereis J, Smith KM. Neuroscientist. 2007 Apr. PMID: 17404377.
Early postnatal astroglial cells produce multilineage precursors and neural stem cells in vivo.Ganat YM, Silbereis J, Cave C, Ngu H, Anderson GM, Ohkubo Y, Ment LR, Vaccarino FM. J Neurosci. 2006 Aug 16. PMID: 16914687.
Midline radial glia translocation and corpus callosum formation require FGF signaling.Smith KM, Ohkubo Y, Maragnoli ME, Rasin MR, Schwartz ML, Sestan N, Vaccarino FM. Nat Neurosci. 2006 Jun; 2006 May 21. PMID: 16715082.