Mark N. Lee, MD, PhD
Assistant Professor of Laboratory MedicineCards
Appointments
Contact Info
Laboratory Medicine
Clinic Building 405, 333 Cedar Street
New Haven, CT 06520
United States
About
Titles
Assistant Professor of Laboratory Medicine
Biography
Dr. Mark Lee is an Assistant Professor in the Department of Laboratory Medicine with a secondary affiliation in the Department of Pathology, and is a member of Yale's Human and Translational Immunology (HTI) Program as well as the Cancer Immunology Research Program at Yale Cancer Center. Dr. Lee received his B.S. and M.S. degrees in Molecular Biophysics & Biochemistry at Yale University, and his M.D. and Ph.D. degrees from Harvard Medical School. He performed his Ph.D. work in Immunology at Harvard Medical School and the Broad Institute of MIT and Harvard, where he studied how common genetic variants alter immune phenotypes. He completed residency in Clinical Pathology at the Brigham and Women's Hospital, followed by a fellowship in Transfusion Medicine in the Harvard Joint Program in Transfusion Medicine, and a postdoctoral fellowship at the Dana-Farber Cancer Institute. He served as an Instructor in Pathology at the Brigham and Women's Hospital and as an attending physician on the Blood Transfusion Service in the Department of Pathology at the Massachusetts General Hospital, prior to joining the faculty at Yale School of Medicine as a physician-scientist.
Appointments
Laboratory Medicine
Assistant ProfessorPrimaryPathology
Assistant ProfessorSecondary
Other Departments & Organizations
- Cancer Immunology
- Human and Translational Immunology Program
- Immunology
- Janeway Society
- Laboratory Medicine
- Mark Lee Lab
- Molecular Medicine, Pharmacology, and Physiology
- Pathology
- Program in Translational Biomedicine (PTB)
- Yale Cancer Center
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Medicine
Education & Training
- Instructor
- Brigham and Women's Hospital (2021)
- Fellow
- Massachusetts General Hospital (2019)
- Resident
- Brigham and Women's Hospital (2018)
- MD
- Harvard Medical School (2015)
- PhD
- Harvard Medical School, Immunology (2013)
- MS
- Yale University, Molecular Biophysics & Biochemistry (2004)
- BS
- Yale University, Molecular Biophysics & Biochemistry (2004)
Board Certifications
Clinical Pathology
- Certification Organization
- AB of Pathology
- Original Certification Date
- 2019
Research
Overview
Medical Research Interests
- View Lab Website
Lee Lab
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
David A. Hafler, MD, FANA
Autoimmune Diseases
Autoimmunity
Adaptive Immunity
Publications
2021
Antigen identification for HLA class I- and HLA class II-restricted T cell receptors using cytokine-capturing antigen-presenting cells.
Lee MN, Meyerson M. Antigen identification for HLA class I- and HLA class II-restricted T cell receptors using cytokine-capturing antigen-presenting cells. Science Immunology 2021, 6 PMID: 33483338, PMCID: PMC8320540, DOI: 10.1126/sciimmunol.abf4001.Peer-Reviewed Original Research
2018
Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of ERAP2 transcripts under balancing selection.
Ye CJ, Chen J, Villani AC, Gate RE, Subramaniam M, Bhangale T, Lee MN, Raj T, Raychowdhury R, Li W, Rogel N, Simmons S, Imboywa SH, Chipendo PI, McCabe C, Lee MH, Frohlich IY, Stranger BE, De Jager PL, Regev A, Behrens T, Hacohen N. Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of ERAP2 transcripts under balancing selection. Genome Research 2018, 28: 1812-1825. PMID: 30446528, PMCID: PMC6280757, DOI: 10.1101/gr.240390.118.Peer-Reviewed Original Research
2017
Systematic STAT3 sequencing in patients with unexplained cytopenias identifies unsuspected large granular lymphocytic leukemia.
Morgan EA, Lee MN, DeAngelo DJ, Steensma DP, Stone RM, Kuo FC, Aster JC, Gibson CJ, Lindsley RC. Systematic STAT3 sequencing in patients with unexplained cytopenias identifies unsuspected large granular lymphocytic leukemia. Blood Advances 2017, 1: 1786-1789. PMID: 29296824, PMCID: PMC5728102, DOI: 10.1182/bloodadvances.2017011197.Peer-Reviewed Original Research
2016
Parsing the Interferon Transcriptional Network and Its Disease Associations.
Mostafavi S, Yoshida H, Moodley D, LeBoité H, Rothamel K, Raj T, Ye CJ, Chevrier N, Zhang SY, Feng T, Lee M, Casanova JL, Clark JD, Hegen M, Telliez JB, Hacohen N, De Jager PL, Regev A, Mathis D, Benoist C. Parsing the Interferon Transcriptional Network and Its Disease Associations. Cell 2016, 164: 564-78. PMID: 26824662, PMCID: PMC4743492, DOI: 10.1016/j.cell.2015.12.032.Peer-Reviewed Original Research
2014
Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes
Raj T, Rothamel K, Mostafavi S, Ye C, Lee MN, Replogle JM, Feng T, Lee M, Asinovski N, Frohlich I, Imboywa S, Von Korff A, Okada Y, Patsopoulos NA, Davis S, McCabe C, Paik HI, Srivastava GP, Raychaudhuri S, Hafler DA, Koller D, Regev A, Hacohen N, Mathis D, Benoist C, Stranger BE, De Jager PL. Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes. Science 2014, 344: 519-523. PMID: 24786080, PMCID: PMC4910825, DOI: 10.1126/science.1249547.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdaptive ImmunityAllelesAlzheimer DiseaseAutoimmune DiseasesAutoimmunityCD4-Positive T-LymphocytesEthnicityGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansImmunity, InnateMonocytesMultiple SclerosisNeurodegenerative DiseasesParkinson DiseasePolymorphism, Single NucleotideQuantitative Trait LociRheumatic FeverTranscriptomeConceptsSpecific immune cell typesHuman immune functionImmune cell typesMulti-ethnic cohortCell-autonomous effectsAutoimmune diseasesT cellsImmune functionParkinson's diseaseHealthy individualsInnate immunityRisk allelesDiseaseExpression quantitative trait loci (eQTL) studiesQuantitative trait loci studiesSusceptibility allelesPutative functional assignmentsCausal regulatory variantsDisease-associated lociDisease susceptibility variantsCell typesSusceptibility variantsTrans-eQTLsFunctional assignmentRegulatory variantsCommon Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells
Lee MN, Ye C, Villani AC, Raj T, Li W, Eisenhaure TM, Imboywa SH, Chipendo PI, Ran FA, Slowikowski K, Ward LD, Raddassi K, McCabe C, Lee MH, Frohlich IY, Hafler DA, Kellis M, Raychaudhuri S, Zhang F, Stranger BE, Benoist CO, De Jager PL, Regev A, Hacohen N. Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells. Science 2014, 343: 1246980. PMID: 24604203, PMCID: PMC4124741, DOI: 10.1126/science.1246980.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdultAutoimmune DiseasesCommunicable DiseasesDendritic CellsEscherichia coliFemaleGene-Environment InteractionGenetic LociGenome-Wide Association StudyHEK293 CellsHost-Pathogen InteractionsHumansInfluenza A virusInterferon Regulatory Factor-7Interferon-betaLipopolysaccharidesMaleMiddle AgedPolymorphism, Single NucleotideQuantitative Trait LociSTAT Transcription FactorsTranscriptomeYoung AdultConceptsGenetic variationPathogen-responsive genesHuman genetic variationGenetic variantsIRF transcription factorsCommon genetic variantsType I IFN inductionFunctional annotationExpression responsesTranscription factorsI IFN inductionCausal variantsPathogen sensingEnvironmental stimuliComplex diseasesCommon variantsCommon allelesIFN inductionComputational approachVariantsCellsInductionGenesInterindividual variationSTAT
2013
Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach.
Lee MN, Roy M, Ong SE, Mertins P, Villani AC, Li W, Dotiwala F, Sen J, Doench JG, Orzalli MH, Kramnik I, Knipe DM, Lieberman J, Carr SA, Hacohen N. Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach. Nature Immunology 2013, 14: 179-85. PMID: 23263557, PMCID: PMC3838897, DOI: 10.1038/ni.2509.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
honor AABB Foundation Scientific Research Grant Award
National AwardAABB (Association for the Advancement of Blood & Biotherapies)Details07/01/2022United States
Get In Touch
Contacts
Laboratory Medicine
Clinic Building 405, 333 Cedar Street
New Haven, CT 06520
United States
Locations
CB405
Lab
Clinic Building
789 Howard Avenue
New Haven, CT 06519