Albert Powers, MD, PhD
Associate Professor of PsychiatryCards
Appointments
Additional Titles
Medical & Associate Director, Yale PRIME Psychosis Risk Clinic, Psychiatry
Contact Info
Appointments
Additional Titles
Medical & Associate Director, Yale PRIME Psychosis Risk Clinic, Psychiatry
Contact Info
Appointments
Additional Titles
Medical & Associate Director, Yale PRIME Psychosis Risk Clinic, Psychiatry
Contact Info
About
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Titles
Associate Professor of Psychiatry
Medical & Associate Director, Yale PRIME Psychosis Risk Clinic, Psychiatry
Biography
Dr. Powers is an Associate Professor at the Yale University Department of Psychiatry and Medical Director and Associate Director of the PRIME Psychosis Risk Clinic at Yale. In addition to treating individuals who suffer from the symptoms of early psychosis, he uses computational approaches to understand how sensory systems might go awry to produce hallucinations and other symptoms of psychosis.
Appointments
Psychiatry
Associate Professor on TermPrimaryDepartment of Psychology
Associate Professor on TermSecondary
Other Departments & Organizations
- Center for Brain & Mind Health
- Department of Psychology
- Interdepartmental Neuroscience Program
- Janeway Society
- MR Core
- Neural Disorders
- Neuroscience Research Training Program (NRTP)
- Neuroscience Track
- Powers Lab
- PRIME Psychosis Prodrome Research Clinic
- Psychiatry
- Wu Tsai Institute
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
Education & Training
- Resident
- Yale School of Medicine (2016)
- Chief Resident, Neuroscience Research Training Program
- Yale School of Medicine (2016)
- PhD
- Vanderbilt University School of Medicine (2012)
- MD
- Vanderbilt University School of Medicine (2012)
- BA
- Yale University (2004)
Research
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Overview
Medical Research Interests
ORCID
0000-0003-3057-5043- View Lab Website
Powers Lab
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Scott Woods, MD
Philip Corlett, PhD
Catalina Mourgues-Codern
Godfrey Pearlson, MA, MBBS
Emily Farina, PhD
Zailyn Tamayo
Psychotic Disorders
Hallucinations
Schizophrenia
Risk Assessment
Computational Biology
Publications
2026
Utility of zoom-based clinical interviews for automated facial emotion analysis
Bertrand C, Gold J, Waltz J, Schiffman J, Ellman L, Strauss G, Walker E, Woods S, Powers A, Kenney J, Corlett P, Silverstein S, Mittal V. Utility of zoom-based clinical interviews for automated facial emotion analysis. Schizophrenia Research 2026, 295: 226-227. PMID: 42302696, DOI: 10.1016/j.schres.2026.06.017.Peer-Reviewed Original ResearchIndividual threat-relevance accelerates belief-updating in conditioned hallucinations
Martin J, Fisher V, Eckert A, Powers A, Sterzer P. Individual threat-relevance accelerates belief-updating in conditioned hallucinations. Scientific Reports 2026, 16: 19557. PMID: 42288502, PMCID: PMC13294484, DOI: 10.1038/s41598-026-52299-9.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsValue representation in youth psychopathology: evidence of a transdiagnostic risk mechanism for psychosis
Millman Z, Gold J, Schiffman J, Ellman L, Walker E, Powers A, Woods S, Silverstein S, Mittal V, Corlett P, Strauss G, Waltz J. Value representation in youth psychopathology: evidence of a transdiagnostic risk mechanism for psychosis. Translational Psychiatry 2026 PMID: 42270591, DOI: 10.1038/s41398-026-04065-8.Peer-Reviewed Original ResearchConceptsClinical high riskNegative symptomsDepressive symptomsNegative symptoms of schizophreniaClinical high-risk youthRisk mechanismsValue representationPsychosis transition ratesValue-guided choiceLower premorbid intelligenceSymptoms of schizophreniaWin-stay behaviorAssociated with deficitsRisk calculator scoresAssociated with multiple indicatorsIntact learningPremorbid intelligenceYouth psychopathologyPsychosis riskAffective disturbancesNeuropsychological assessmentImpaired learningSymptom InterviewPsychosisClinical groupsComputerized assessments of emotional expression and emotional reactivity predict negative symptoms in individuals at clinical high-risk for psychosis
Bertrand C, Pokorny V, Gold J, Waltz J, Schiffman J, Ellman L, Strauss G, Walker E, Woods S, Powers A, Kenney J, Corlett P, Silverstein S, Mittal V. Computerized assessments of emotional expression and emotional reactivity predict negative symptoms in individuals at clinical high-risk for psychosis. Psychological Medicine 2026, 56: e184. PMID: 42267441, PMCID: PMC13280694, DOI: 10.1017/s0033291726104826.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsClinical high riskInternational Affective Picture SystemNegative symptom domainsHappy facial expressionsEmotional reactivityNegative symptomsFacial expressionsSymptom domainsEmotional expressionComputerized assessmentClinical high-risk individualsClinical high-risk participantsAssessment of emotional expressionCore featuresClinical high-risk groupHealthy controlsFeatures of psychosisPredictor of functional outcomePositive symptomsMotivational symptomsDisgust expressionsExpressive deficitsPsychosis riskClinical InterviewPicture SystemComputerized Assessments of Perceptual Organization Uniquely Predict Hallucinations and Perceptual Distortions in Individuals at Clinical High Risk for Psychosis
Pokorny V, Williams T, Pratt D, Kenney J, Ellman L, Strauss G, Walker E, Woods S, Powers A, Corlett P, Thompson J, Silverstein S, Waltz J, Gold J, Schiffman J, Mittal V. Computerized Assessments of Perceptual Organization Uniquely Predict Hallucinations and Perceptual Distortions in Individuals at Clinical High Risk for Psychosis. Biological Psychiatry 2026, 99: s38. DOI: 10.1016/j.biopsych.2026.03.097.Peer-Reviewed Original ResearchAltmetric7. Distinct Circuits Are Associated With Attenuated Delusions and Hallucinations in Clinical High Risk for Psychosis
Vin R, Fonteneau C, Tamayo Z, Cho Y, Investigators A, Scheinost D, Woods S, Powers A. 7. Distinct Circuits Are Associated With Attenuated Delusions and Hallucinations in Clinical High Risk for Psychosis. Biological Psychiatry 2026, 99: s77-s78. DOI: 10.1016/j.biopsych.2026.03.187.Peer-Reviewed Original Research747. Reproductive Hormone Disruption and Psychosis Risk in Midlife Women: Evidence From Surgical Models and Lifetime Estrogen Exposure
Gibbs-Dean T, Dandawate A, Patel P, Kelley M, Ntongo B, Farina E, Woods S, Pal L, Powers A. 747. Reproductive Hormone Disruption and Psychosis Risk in Midlife Women: Evidence From Surgical Models and Lifetime Estrogen Exposure. Biological Psychiatry 2026, 99: s418. DOI: 10.1016/j.biopsych.2026.03.981.Peer-Reviewed Original ResearchThreading the needle: Practical considerations for merging theory-driven computational psychiatry with data-driven analytics to enhance precision health at scale
Cheng A, Konova A, Powers A, Corlett P, Levy I, Gu X, Huys Q, Pushkarskaya H, Fineberg S, Hauser T, Chase H, Bzdok D, Harpaz-Rotem I, Babuscio T, Nichols L, Zhao Y, Sharma M, Meeker D, Xu H, Rutledge R, Pearlson G, Pittenger C, Yip S. Threading the needle: Practical considerations for merging theory-driven computational psychiatry with data-driven analytics to enhance precision health at scale. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2026 PMID: 41763489, DOI: 10.1016/j.bpsc.2026.02.009.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsComputational psychiatryLongitudinal trajectoriesLongitudinal dataParsing heterogeneityDiagnostic boundariesBehavioral tasksPsychiatric disordersPsychiatric diagnosticsDimensional approachLongitudinal courseSymptom trajectoriesCognitive processesDiagnostic categoriesPsychiatryIndividual changesUnderlying mechanismsClinical research methodsClinical researchHiTOPRDoCIndividualsClinical realityDisordersSymptomsTaskComputational phenotypes underlying effort-based decision-making and negative symptoms in a transdiagnostic severe mental illness sample
Luther L, Cooper J, Treadway M, Knippenberg A, Walker E, Gold J, Waltz J, Schiffman J, Ellman L, Mittal V, Zinbarg R, Silverstein S, Corlett P, Powers A, Woods S, Allen D, Lahti A, Strauss G. Computational phenotypes underlying effort-based decision-making and negative symptoms in a transdiagnostic severe mental illness sample. Molecular Psychiatry 2026, 31: 3435-3445. PMID: 41691110, PMCID: PMC13285297, DOI: 10.1038/s41380-026-03474-x.Peer-Reviewed Original ResearchAltmetricConceptsEffort-based decision-makingNegative symptomsReward magnitudeDepressive disorderNegative symptom measuresClinical high riskFirst-episode psychosisMentally ill sampleMultiple psychiatric diagnosesReward taskSymptom measuresBipolar disorderNeuropsychological testsEffort expenditurePsychiatric diagnosisIll sampleDiagnostic groupsSubjective valueHealthy control groupCognitive impairmentHC groupBias modelRewardDisordersPsychosisStepped care for young people at clinical high risk for psychosis: a real-world study
Broekhuijse A, Saxena A, Walsh B, Mourgues-Codern C, Mukhtar H, Howard S, Woods SW, Powers AR, Farina EA. Stepped care for young people at clinical high risk for psychosis: a real-world study. 2026 DOI: 10.64898/2026.02.05.26345683.Peer-Reviewed Original Research In Press
Clinical Trials
Current Trials
Song-making In a Group (SING)
IRB ID2000026376RoleSub InvestigatorPrimary Completion Date08/31/2024Recruiting ParticipantsSchizophrenia Spectrum Biomarkers Consortium (SSBC)
IRB ID2000029485RoleSub InvestigatorPrimary Completion Date12/31/2030Recruiting ParticipantsTesting a Computationally-Informed, Personalized Intervention for Hallucinations
IRB ID2000024774RolePrincipal InvestigatorPrimary Completion Date03/31/2024Recruiting ParticipantsGenderBothAge18 years - 65 yearsAMPA Receptor Components of the Anti-Depressant Ketamine Response
IRB ID2000021345RoleSub InvestigatorPrimary Completion Date06/30/2032Recruiting ParticipantsGenderBothAge18 years - 65 years
Academic Achievements & Community Involvement
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Activities
activity American College of Neuropsychopharmacology (ACNP)
2022 - PresentProfessional OrganizationsAssociateDetailsAssociate Memberactivity Schizophrenia Research
11/01/2020 - 01/01/2022Journal ServiceGuest EditorDetailsGuest Editor, Special Issue on Computational Approaches to Understanding Psychosis
Honors
honor Young Physician-Scientist Award
01/26/2022National AwardAmerican Society for Clinical InvestigationDetailsUnited Stateshonor Carol and Eugene Ludwig Award for Early Career Research
12/08/2021National AwardLudwig Family FoundationDetailsUnited Stateshonor Second Prize, Yale Digital Pitchfest
12/01/2021Yale University AwardYale Office for Cooperative ResearchDetailsUnited Stateshonor Participant
07/18/2018National AwardCareer Development Institute for PsychiatryDetailsUnited Stateshonor New Investigator Award
07/18/2018National AwardAmerican Society of Clinical PsychopharmacologyDetailsUnited States
News
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News
- March 23, 2026
Powers Honored with SIRS Research Excellence Award
- December 08, 2025Source: ScienceLine
Virtual Reality Therapy May Reduce Voice Hallucinations in People with Schizophrenia
- May 27, 2025Source: Undark
When People Hear Voices, But Only When They Want To
- April 08, 2025
Understanding the Transition From Early to Chronic Psychosis
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