2024
Irritability in Youths: A Critical Integrative Review
Leibenluft E, Allen L, Althoff R, Brotman M, Burke J, Carlson G, Dickstein D, Dougherty L, Evans S, Kircanski K, Klein D, Malone E, Mazefsky C, Nigg J, Perlman S, Pine D, Roy A, Salum G, Shakeshaft A, Silver J, Stoddard J, Thapar A, Tseng W, Vidal-Ribas P, Wakschlag L, Stringaris A. Irritability in Youths: A Critical Integrative Review. American Journal Of Psychiatry 2024, 181: 275-290. PMID: 38419494, DOI: 10.1176/appi.ajp.20230256.Peer-Reviewed Original ResearchAttention deficit hyperactivity disorderPathophysiology of irritabilityResponse to frustrationParent management trainingTreating psychological problemsDeficit hyperactivity disorderAutism spectrum disorderPrevalence of irritabilityAssociated with impairmentDiverse longitudinal sampleAssociated with increased risk of anxietyRisk of anxietyYouth irritabilityAnxiety disordersTreating irritabilityHyperactivity disorderBehavior problemsSpectrum disorderDevelopmental trajectoriesAssess irritabilityPsychological problemsLongitudinal sampleImpact of cultural contextTranslational findingsSuicide
2022
Persistent Frustration-Induced Reconfigurations of Brain Networks Predict Individual Differences in Irritability
Linke J, Haller S, Xu E, Nguyen L, Chue A, Botz-Zapp C, Revzina O, Perlstein S, Ross A, Tseng W, Shaw P, Brotman M, Pine D, Gotts S, Leibenluft E, Kircanski K. Persistent Frustration-Induced Reconfigurations of Brain Networks Predict Individual Differences in Irritability. Journal Of The American Academy Of Child & Adolescent Psychiatry 2022, 62: 684-695. PMID: 36563874, PMCID: PMC11224120, DOI: 10.1016/j.jaac.2022.11.009.Peer-Reviewed Original ResearchConceptsResting-state scansPathophysiology of irritabilitySelf-reported irritabilityFunctional magnetic resonance imagingMagnetic resonance imagingParent-reported irritabilitySpecific intervention targetsRisk factorsMotor functionPsychiatric consultationCircuit reorganizationCommon reasonAffective disordersBrain network configurationIrritability symptomsResonance imagingBrain regionsIrritabilityCentral mechanismsAberrant responsesPilot studyIntervention targetsRecovery periodPediatric irritabilityBrain networks
2017
Association of Irritability and Anxiety With the Neural Mechanisms of Implicit Face Emotion Processing in Youths With Psychopathology
Stoddard J, Tseng WL, Kim P, Chen G, Yi J, Donahue L, Brotman MA, Towbin KE, Pine DS, Leibenluft E. Association of Irritability and Anxiety With the Neural Mechanisms of Implicit Face Emotion Processing in Youths With Psychopathology. JAMA Psychiatry 2017, 74: 95-103. PMID: 27902832, PMCID: PMC6309540, DOI: 10.1001/jamapsychiatry.2016.3282.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmygdalaAnxiety DisordersArousalAttention Deficit Disorder with HyperactivityBrainChildCross-Sectional StudiesDominance, CerebralEmotionsFacial RecognitionFemaleHumansIrritable MoodMagnetic Resonance ImagingMaleMental DisordersMood DisordersNerve NetPrefrontal CortexPsychopathologyConceptsFunctional magnetic resonance imagingPrefrontal cortex connectivityFace emotionsNeural responsesCortex connectivityMedial prefrontal cortex connectivityAttention-deficit/hyperactivity disorderChild Anxiety Related DisordersThreat-related facesDisruptive Mood DysregulationPathophysiology of irritabilityFace emotion processingAmygdala-medial prefrontal cortex connectivityCross-sectional functional magnetic resonanceAffective Reactivity IndexBrain-behavior relationshipsVentral visual areasAssociations of irritabilityUnique effectsAmygdala functional connectivityAnxiety Related DisordersFunctional magnetic resonanceYouth ages 8Angry facesFearful faces