2023
Peer functioning difficulties may exacerbate symptoms of attention‐deficit/hyperactivity disorder and irritability over time: a temporal network analysis
Bellaert N, Morreale K, Tseng W. Peer functioning difficulties may exacerbate symptoms of attention‐deficit/hyperactivity disorder and irritability over time: a temporal network analysis. Journal Of Child Psychology And Psychiatry 2023, 65: 809-821. PMID: 37859512, PMCID: PMC11026298, DOI: 10.1111/jcpp.13911.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorderPositive social interactionsPeer functioningADHD symptomsIrritability symptomsHyperactivity disorderSocial interactionChild ADHD symptomsSocial-emotional skillsPelham Rating ScaleNegative social environmentsPeer rejectionPeer acceptancePeer nominationsSocial impairmentNovel longitudinal approachPhysical bullyingCommunity samplePoor peerPhysical victimizationInattentionMutual friendshipsLongitudinal associationsTemper outburstsFrequent temper outburstsAutistic Symptoms, Irritability, and Executive Dysfunctions: Symptom Dynamics from Multi-Network Models
Lee K, Gau S, Tseng W. Autistic Symptoms, Irritability, and Executive Dysfunctions: Symptom Dynamics from Multi-Network Models. Journal Of Autism And Developmental Disorders 2023, 54: 3078-3093. PMID: 37453959, DOI: 10.1007/s10803-023-05981-0.Peer-Reviewed Original ResearchAutism spectrum disorderIrritability symptomsExecutive functionExecutive dysfunctionAutistic symptomsCognitive-behavioral mechanismsSocial communication difficultiesRelative importance networksSample of childrenNeurotypical peersElevated irritabilityASD diagnosisSpectrum disorderBridge symptomsCommunication difficultiesTemper outburstsPredictive pathSymptom dynamicsUnaffected siblingsPartial correlationMoodEntire sampleIrritabilitySpecific relationSymptom nodes
2022
Persistent Frustration-Induced Reconfigurations of Brain Networks Predict Individual Differences in Irritability
Linke J, Haller S, Xu E, Nguyen L, Chue A, Botz-Zapp C, Revzina O, Perlstein S, Ross A, Tseng W, Shaw P, Brotman M, Pine D, Gotts S, Leibenluft E, Kircanski K. Persistent Frustration-Induced Reconfigurations of Brain Networks Predict Individual Differences in Irritability. Journal Of The American Academy Of Child & Adolescent Psychiatry 2022, 62: 684-695. PMID: 36563874, PMCID: PMC11224120, DOI: 10.1016/j.jaac.2022.11.009.Peer-Reviewed Original ResearchConceptsResting-state scansPathophysiology of irritabilitySelf-reported irritabilityFunctional magnetic resonance imagingMagnetic resonance imagingParent-reported irritabilitySpecific intervention targetsRisk factorsMotor functionPsychiatric consultationCircuit reorganizationCommon reasonAffective disordersBrain network configurationIrritability symptomsResonance imagingBrain regionsIrritabilityCentral mechanismsAberrant responsesPilot studyIntervention targetsRecovery periodPediatric irritabilityBrain networksCharacterizing the Neural Correlates of Response Inhibition and Error Processing in Children With Symptoms of Irritability and/or Attention-Deficit/Hyperactivity Disorder in the ABCD Study®
Lee KS, Xiao J, Luo J, Leibenluft E, Liew Z, Tseng WL. Characterizing the Neural Correlates of Response Inhibition and Error Processing in Children With Symptoms of Irritability and/or Attention-Deficit/Hyperactivity Disorder in the ABCD Study®. Frontiers In Psychiatry 2022, 13: 803891. PMID: 35308882, PMCID: PMC8931695, DOI: 10.3389/fpsyt.2022.803891.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorderResponse inhibitionError processingNeural correlatesIrritability symptomsHyperactivity disorderHigher attention-deficit/hyperactivity disorderAdolescent Brain Cognitive Development (ABCD) studySymptoms of inattentionDifferential neural mechanismsCognitive Development StudyStop-signal taskLow frustration toleranceLatent class analysisFronto-parietal regionsLatent variable modelingPediatric irritabilityNeural differencesIndividual differencesSignal taskExecutive dysfunctionFrustration toleranceNeural mechanismsABCD studyHigh irritability
2020
A preliminary study on functional activation and connectivity during frustration in youths with bipolar disorder
Ross AJ, Roule AL, Deveney CM, Towbin KE, Brotman MA, Leibenluft E, Tseng W. A preliminary study on functional activation and connectivity during frustration in youths with bipolar disorder. Bipolar Disorders 2020, 23: 263-273. PMID: 32790927, PMCID: PMC8074834, DOI: 10.1111/bdi.12985.Peer-Reviewed Original ResearchConceptsInferior frontal gyrusFeedback processingBD youthNeural responsesReward-relevant stimuliFunctional activationSelf-reported frustrationSelf-reported affectAtypical activation patternsGoal-directed behaviorPrefrontal cortex connectivityBipolar disorderBipolar disorder youthAttentional abilitiesAttention taskImpaired attentionFMRI paradigmTask performanceFrontal gyrusAttention networkGreater recruitmentCortex connectivityGreater unhappinessIrritability symptomsInterest activation