2024
Irritability in Youths: A Critical Integrative Review
Leibenluft E, Allen L, Althoff R, Brotman M, Burke J, Carlson G, Dickstein D, Dougherty L, Evans S, Kircanski K, Klein D, Malone E, Mazefsky C, Nigg J, Perlman S, Pine D, Roy A, Salum G, Shakeshaft A, Silver J, Stoddard J, Thapar A, Tseng W, Vidal-Ribas P, Wakschlag L, Stringaris A. Irritability in Youths: A Critical Integrative Review. American Journal Of Psychiatry 2024, 181: 275-290. PMID: 38419494, DOI: 10.1176/appi.ajp.20230256.Peer-Reviewed Original ResearchAttention deficit hyperactivity disorderPathophysiology of irritabilityResponse to frustrationParent management trainingTreating psychological problemsDeficit hyperactivity disorderAutism spectrum disorderPrevalence of irritabilityAssociated with impairmentDiverse longitudinal sampleAssociated with increased risk of anxietyRisk of anxietyYouth irritabilityAnxiety disordersTreating irritabilityHyperactivity disorderBehavior problemsSpectrum disorderDevelopmental trajectoriesAssess irritabilityPsychological problemsLongitudinal sampleImpact of cultural contextTranslational findingsSuicide
2023
Peer functioning difficulties may exacerbate symptoms of attention‐deficit/hyperactivity disorder and irritability over time: a temporal network analysis
Bellaert N, Morreale K, Tseng W. Peer functioning difficulties may exacerbate symptoms of attention‐deficit/hyperactivity disorder and irritability over time: a temporal network analysis. Journal Of Child Psychology And Psychiatry 2023, 65: 809-821. PMID: 37859512, PMCID: PMC11026298, DOI: 10.1111/jcpp.13911.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorderPositive social interactionsPeer functioningADHD symptomsIrritability symptomsHyperactivity disorderSocial interactionChild ADHD symptomsSocial-emotional skillsPelham Rating ScaleNegative social environmentsPeer rejectionPeer acceptancePeer nominationsSocial impairmentNovel longitudinal approachPhysical bullyingCommunity samplePoor peerPhysical victimizationInattentionMutual friendshipsLongitudinal associationsTemper outburstsFrequent temper outbursts
2022
Atypical development in white matter microstructures in ADHD: A longitudinal diffusion imaging study
Chiang H, Tseng W, Tseng W, Tung Y, Hsu Y, Chen C, Gau S. Atypical development in white matter microstructures in ADHD: A longitudinal diffusion imaging study. Asian Journal Of Psychiatry 2022, 79: 103358. PMID: 36481569, DOI: 10.1016/j.ajp.2022.103358.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderInferior fronto-occipital fasciculusGeneralized fractional anisotropyAttention performanceWhite matter microstructureDevelopmental trajectoriesComputerized continuous performance testAtypical developmental trajectoriesContinuous Performance TestDiffusion spectrum imagingFrontal aslant tractWhite matter tractsInattention symptomsAtypical developmentADHD symptomsHyperactivity disorderSuperior longitudinal fasciculusPrefrontal cortexFrontostriatal tractsImaging studiesArcuate fasciculusDevelopmental changesFronto-occipital fasciculusNeuroplastic processesDiagnosis interactionCharacterizing the Neural Correlates of Response Inhibition and Error Processing in Children With Symptoms of Irritability and/or Attention-Deficit/Hyperactivity Disorder in the ABCD Study®
Lee KS, Xiao J, Luo J, Leibenluft E, Liew Z, Tseng WL. Characterizing the Neural Correlates of Response Inhibition and Error Processing in Children With Symptoms of Irritability and/or Attention-Deficit/Hyperactivity Disorder in the ABCD Study®. Frontiers In Psychiatry 2022, 13: 803891. PMID: 35308882, PMCID: PMC8931695, DOI: 10.3389/fpsyt.2022.803891.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorderResponse inhibitionError processingNeural correlatesIrritability symptomsHyperactivity disorderHigher attention-deficit/hyperactivity disorderAdolescent Brain Cognitive Development (ABCD) studySymptoms of inattentionDifferential neural mechanismsCognitive Development StudyStop-signal taskLow frustration toleranceLatent class analysisFronto-parietal regionsLatent variable modelingPediatric irritabilityNeural differencesIndividual differencesSignal taskExecutive dysfunctionFrustration toleranceNeural mechanismsABCD studyHigh irritability
2021
Functional connectivity during frustration: a preliminary study of predictive modeling of irritability in youth
Scheinost D, Dadashkarimi J, Finn ES, Wambach CG, MacGillivray C, Roule AL, Niendam TA, Pine DS, Brotman MA, Leibenluft E, Tseng WL. Functional connectivity during frustration: a preliminary study of predictive modeling of irritability in youth. Neuropsychopharmacology 2021, 46: 1300-1306. PMID: 33479511, PMCID: PMC8134471, DOI: 10.1038/s41386-020-00954-8.Peer-Reviewed Original ResearchConceptsFunctional connectivityAttention-deficit/hyperactivity disorderCognitive flexibility taskDisruptive mood dysregulation disorderAffective Reactivity IndexLevels of irritabilityPreliminary fMRI studyCognitive flexibilityFlexibility taskIndividual differencesTransdiagnostic sampleFrontal networkFMRI studyHyperactivity disorderTask difficultyNeural mechanismsParent reportAnxiety symptomsSalience networkAnxiety disordersFrustrative nonrewardDimensional measuresPreliminary evidenceReactivity indexChild psychiatry
2020
Editorial: A Transdiagnostic Symptom Requires a Transdiagnostic Approach: Neural Mechanisms of Pediatric Irritability
Tseng WL. Editorial: A Transdiagnostic Symptom Requires a Transdiagnostic Approach: Neural Mechanisms of Pediatric Irritability. Journal Of The American Academy Of Child & Adolescent Psychiatry 2020, 59: 1327-1329. PMID: 32966839, PMCID: PMC8143431, DOI: 10.1016/j.jaac.2020.09.008.Peer-Reviewed Original ResearchConceptsDisruptive mood dysregulation disorderAttention-deficit/hyperactivity disorderOppositional defiant disorderLong-term impairmentDSM-5 categoriesPediatric disordersHigh suicidalityAnxiety disordersHyperactivity disorderDisordersIrritabilityDefiant disorderHallmark featurePediatric irritabilityTransdiagnostic symptomsNeural mechanismsTransdiagnostic approachAutism spectrum disorderChild psychiatrySpectrum disorderA Deep Learning Approach for Missing Data Imputation of Rating Scales Assessing Attention-Deficit Hyperactivity Disorder
Cheng CY, Tseng WL, Chang CF, Chang CH, Gau SS. A Deep Learning Approach for Missing Data Imputation of Rating Scales Assessing Attention-Deficit Hyperactivity Disorder. Frontiers In Psychiatry 2020, 11: 673. PMID: 32765316, PMCID: PMC7379397, DOI: 10.3389/fpsyt.2020.00673.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorderContinuous Performance TestHyperactivity disorderTeacher reportsConners' Continuous Performance TestAttention deficit hyperactivity disorderHyperactivity/impulsivityVersion IV scaleADHD Rating ScaleTD groupOppositional behaviorADHD diagnosisConners ratingsBehavioral studiesBehavioral symptomsImputation orderChinese versionYouthDeep learning approachShort formParentsImputed datasetDeep learning methodsRating ScalePerformance tests
2019
Psychiatric comorbid patterns in adults with attention-deficit hyperactivity disorder: Treatment effect and subtypes
Tsai FJ, Tseng WL, Yang LK, Gau SS. Psychiatric comorbid patterns in adults with attention-deficit hyperactivity disorder: Treatment effect and subtypes. PLOS ONE 2019, 14: e0211873. PMID: 30730956, PMCID: PMC6366698, DOI: 10.1371/journal.pone.0211873.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderDrug-naïve adultsChildhood attention-deficit/hyperactivity disorderPsychiatric comorbidityMedication treatmentHigh riskTreatment durationHyperactivity disorderSemi-structured psychiatric interviewCurrent medication treatmentHealthy adult controlsEffects of medicationLonger treatment durationShorter treatment durationAttention deficit hyperactivity disorderADHD inattentive subtypeMore comorbiditiesMedical recordsHealthy controlsMood disordersSleep disordersComorbiditiesPsychiatric interviewLower riskADHD subtypes
2014
Symptoms of Attention-Deficit/Hyperactivity Disorder and Peer Functioning: a Transactional Model of Development
Tseng WL, Kawabata Y, Gau SS, Crick NR. Symptoms of Attention-Deficit/Hyperactivity Disorder and Peer Functioning: a Transactional Model of Development. Research On Child And Adolescent Psychopathology 2014, 42: 1353-1365. PMID: 24830516, DOI: 10.1007/s10802-014-9883-8.Peer-Reviewed Original ResearchConceptsHyperactivity/impulsivityPeer functioningPeer impairmentADHD symptomsPeer relationshipsAttention-deficit/hyperactivity disorderShort-term longitudinal studyChild ADHD symptomsVersion IV scaleChildren's peer relationshipsCross-lagged modelsNumber of friendshipsInattentive symptomsPeer rejectionTransactional interplayPeer acceptanceHyperactivity disorderPeer nominationsTransactional modelParent reportPhysical aggressionCommunity sampleInattentionNegative facetsImpulsivity
2013
Executive function as a mediator in the link between attention‐deficit/hyperactivity disorder and social problems
Tseng W, Gau S. Executive function as a mediator in the link between attention‐deficit/hyperactivity disorder and social problems. Journal Of Child Psychology And Psychiatry 2013, 54: 996-1004. PMID: 23574361, DOI: 10.1111/jcpp.12072.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderExecutive functionADHD youthHyperactivity disorderEffects of ADHDCambridge Neuropsychological Test Automated BatteryAspects of EFSocial problemsExecutive function measuresSubgroups of youthCognitive processesADHD groupResponse inhibitionADHD symptomsADHD severityChild reportsYouthFunction measuresMemoryStrong linkSubtestsIQDisordersMeasuresDeficits
2011
Symptoms of Attention-Deficit/Hyperactivity Disorder and Social and School Adjustment: The Moderating Roles of Age and Parenting
Kawabata Y, Tseng WL, Gau SS. Symptoms of Attention-Deficit/Hyperactivity Disorder and Social and School Adjustment: The Moderating Roles of Age and Parenting. Research On Child And Adolescent Psychopathology 2011, 40: 177-188. PMID: 21858455, DOI: 10.1007/s10802-011-9556-9.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderChild's ageSchool adjustmentADHD symptomsAttention problemsHyperactivity disorderMaternal parentingAcademic performanceDevelopmental psychopathology perspectiveMaternal affectionSocial adjustment problemsNegative peer relationshipsOlder childrenPsychopathology perspectiveSocial adjustmentPeer relationshipsAdjustment problemsMaternal overprotectionModerating RoleParentingNinth gradeYoung childrenOverprotectionSocial problemsChildren
2007
A Randomized, Double-Blind, Placebo-Controlled Clinical Trial on Once-Daily Atomoxetine Hydrochloride in Taiwanese Children and Adolescents with Attention-Deficit/Hyperactivity Disorder
Gau SS, Huang YS, Soong WT, Chou MC, Chou WJ, Shang CY, Tseng WL, Allen AJ, Lee P. A Randomized, Double-Blind, Placebo-Controlled Clinical Trial on Once-Daily Atomoxetine Hydrochloride in Taiwanese Children and Adolescents with Attention-Deficit/Hyperactivity Disorder. Journal Of Child And Adolescent Psychopharmacology 2007, 17: 447-460. PMID: 17822340, DOI: 10.1089/cap.2006.0091.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdrenergic Uptake InhibitorsAppetiteAtomoxetine HydrochlorideAttention Deficit Disorder with HyperactivityChildDouble-Blind MethodDrug Administration ScheduleFacultyFemaleHumansMaleNauseaParentsPropylaminesPsychiatric Status Rating ScalesSeverity of Illness IndexTaiwanTreatment OutcomeConceptsAttention-deficit/hyperactivity disorderPrimary efficacy measureEfficacy measuresDaily atomoxetineAdverse eventsADHD Rating Scale-IV-Parent VersionDrug-related serious adverse eventsHyperactivity disorderSecondary efficacy measuresSerious adverse eventsClinical Global ImpressionCarried-forward approachEnd of studyTreatment effect sizeAtomoxetine groupPlacebo groupTreat basisPediatric patientsGlobal ImpressionSafe treatmentClinical trialsInvestigator AdministeredEdition criteriaTreatment groupsMental disordersAssociation Between Sleep Problems and Symptoms of Attention-Deficit/Hyperactivity Disorder in Young Adults
Gau SS, Kessler RC, Tseng WL, Wu YY, Chiu YN, Yeh CB, Hwu HG. Association Between Sleep Problems and Symptoms of Attention-Deficit/Hyperactivity Disorder in Young Adults. Sleep 2007, 30: 195-201. PMID: 17326545, DOI: 10.1093/sleep/30.2.195.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderAdult ADHD Self-Report ScaleADHD Self-Report ScaleSelf-report scalesADHD groupSleep problemsNocturnal sleep durationHyperactivity disorderYoung adultsSleep needNon-ADHD groupsProbable attention deficit/hyperactivity disorderGreater sleep needFirst-year college studentsSleep durationSleep-related problemsHyperactivity symptomsHyperactivity subscaleCommunity sampleInattentionPrior findingsSleep scheduleCollege studentsCross-sectional surveyChinese version