2023
Acetate controls endothelial-to-mesenchymal transition
Zhu X, Wang Y, Soaita I, Lee H, Bae H, Boutagy N, Bostwick A, Zhang R, Bowman C, Xu Y, Trefely S, Chen Y, Qin L, Sessa W, Tellides G, Jang C, Snyder N, Yu L, Arany Z, Simons M. Acetate controls endothelial-to-mesenchymal transition. Cell Metabolism 2023, 35: 1163-1178.e10. PMID: 37327791, PMCID: PMC10529701, DOI: 10.1016/j.cmet.2023.05.010.Peer-Reviewed Original ResearchConceptsTGF-β signalingChronic vascular diseaseTGF-β receptor ALK5Mesenchymal transitionInduction of EndMTVascular diseaseMolecular basisPositive feedback loopReceptor ALK5Cellular levelSMADs 2Novel targetEndMT inductionMetabolic modulationMetabolic basisFibrotic stateSignalingPotential treatmentEndMTTGFDiseaseActivationInductionACSS2PDK4
1997
Regulation of Endothelial Nitric Oxide Synthase by Estrogen
Caulin-Glaser T, Sessa W, Bender J. Regulation of Endothelial Nitric Oxide Synthase by Estrogen. Ernst Schering Foundation Symposium Proceedings 1997, 217-232. DOI: 10.1007/978-3-662-03503-0_9.Peer-Reviewed Original ResearchNitric oxideL-arginineAbnormal endothelial cell functionImportant endothelium-derived vasodilatorsEndothelial nitric oxide synthaseVascular smooth muscle cell proliferationVascular smooth muscle relaxationEndothelium-derived vasodilatorsSmooth muscle cell proliferationInhibits neointima formationNitric oxide synthaseSmooth muscle relaxationDifferent NOS isoformsNitric oxide synthase regulationMuscle cell proliferationSoluble guanylate cyclaseEndothelial cell functionNitric oxide synthase (NOS) familyVascular relaxationPlatelet aggregabilityVascular diseaseEndothelial NOSOxide synthaseAntiatherogenic propertiesMuscle relaxation