2023
An Alternative to Cytology in Triaging Cisgender Men and Transgender Women With HIV for High-Resolution Anoscopy
Mudrinich S, Nguyen M, Blemur D, Wang X, Wang Y, Krishnamurti U, Mosunjac M, Flowers L. An Alternative to Cytology in Triaging Cisgender Men and Transgender Women With HIV for High-Resolution Anoscopy. Journal Of Lower Genital Tract Disease 2023, 28: 101-106. PMID: 38117565, DOI: 10.1097/lgt.0000000000000773.Peer-Reviewed Original ResearchConceptsHigh-risk human papillomavirus (hrHPV) testingLow CD4 countRisk factorsTriage toolAnal cytologyCD4 countTransgender womenAdult cisgender menHigh-Resolution AnoscopyHuman papillomavirus testingCisgender menPredictive risk factorsRetrospective cohort studySignificant risk factorsSociodemographic risk factorsNegative predictive valueNovel triage toolHrHPV positivityUnderwent cytologyHrHPV testingCohort studyAnal neoplasiaScreening patternsPredictive valueHIVThe correlation of ESR1 genetic aberrations with estrogen receptor and progesterone receptor status in metastatic and primary estrogen receptor-positive breast carcinomas
Moreira-Dinzey J, Zhan H, Rozenblit M, Krishnamurti U, Harigopal M, Zhong M, Liang Y. The correlation of ESR1 genetic aberrations with estrogen receptor and progesterone receptor status in metastatic and primary estrogen receptor-positive breast carcinomas. Human Pathology 2023, 137: 56-62. PMID: 37127079, DOI: 10.1016/j.humpath.2023.04.017.Peer-Reviewed Original ResearchConceptsMetastatic tumorsBreast carcinomaGenetic aberrationsPR statusPrimary tumorBreast cancerControl groupER/PR statusEstrogen receptor-positive breast carcinomasER-positive breast cancerER positivity rateMetastatic breast cancerProgesterone receptor statusMetastatic breast carcinomaMore liver metastasesPrimary breast carcinomaWild-type groupEstrogen receptor 1 geneReceptor 1 geneWild-type controlsLiver metastasesReceptor statusClinicopathological featuresER expressionControl tumors
2022
Human papillomavirus 16/18/45 are not the most frequent genotypes in African American women: analysis in cervical Papanicolaou smears of women in an inner-city hospital
Dababneh M, Birdsong G, Mosunjac M, Krishnamurti U. Human papillomavirus 16/18/45 are not the most frequent genotypes in African American women: analysis in cervical Papanicolaou smears of women in an inner-city hospital. Journal Of The American Society Of Cytopathology 2022, 12: 120-125. PMID: 36585313, DOI: 10.1016/j.jasc.2022.11.005.Peer-Reviewed Original ResearchConceptsHR-HPV genotypesAfrican American womenIntraepithelial lesionsPap testHigh-grade squamous intraepithelial lesion casesHigh-grade squamous intraepithelial lesionsCommon high-risk HPVHPV molecular testingHigh-risk HPVSquamous intraepithelial lesionsCervical Pap testBethesda classification systemCommon human papillomavirusCervical Papanicolaou smearsInner-city hospitalSecondary prevention methodsAmerican womenHR-HPVHPV vaccineHPV genotypesCervical cancerHuman papillomavirusPapanicolaou smearsAfrican American populationLesion casesFurther Characterization of Clinicopathologic Features of Cystic Neutrophilic Granulomatous Mastitis
Liang Y, Zhan H, Krishnamurti U, Harigopal M, Sun T. Further Characterization of Clinicopathologic Features of Cystic Neutrophilic Granulomatous Mastitis. American Journal Of Clinical Pathology 2022, 158: 488-493. PMID: 35899981, DOI: 10.1093/ajcp/aqac074.Peer-Reviewed Original ResearchConceptsCystic neutrophilic granulomatous mastitisGranulomatous mastitisClinicopathologic characteristicsClinicopathologic featuresHigher Breast Imaging ReportingUnique infectious diseaseHospital-based cohortDistinct clinicopathologic featuresMass-like lesionCase-control studyData System scoreBreast Imaging ReportingPainful lesionsRadiologic studiesClinicopathologic profileSystem scoreImaging ReportingDemographic featuresInfectious diseasesPatientsLesionsDiseaseMastitisFurther characterizationSmokersNeighborhood characteristics and breast tumor methylation: using epigenomics to explore cancer outcome disparities
Gohar J, Do W, Miller-Kleinhenz J, Conneely K, Krishnamurti U, D’Angelo O, Gogineni K, Torres M, Gabram-Mendola S, McCullough L. Neighborhood characteristics and breast tumor methylation: using epigenomics to explore cancer outcome disparities. Breast Cancer Research And Treatment 2022, 191: 653-663. PMID: 34978015, DOI: 10.1007/s10549-021-06430-1.Peer-Reviewed Original ResearchConceptsNeighborhood-level factorsCause mortalityMultivariable Cox proportional hazards modelsCox proportional hazards modelCancer outcome disparitiesBreast cancer outcomesTumor methylationProportional hazards modelNon-Hispanic blacksArea-level factorsCancer outcomesFalse discovery rate thresholdBody of evidenceCancer disparitiesBreast cancerOutcome disparitiesCpG sitesTumor progressionTumor tissueWhite womenGuanine dinucleotide sitesRacial disparitiesMortalityTumor epigenomeLinear regression models
2021
Programmed Death Ligand-1 Expression Is Associated With Poorer Survival in Anal Squamous Cell Carcinoma.
Monsrud A, Avadhani V, Mosunjac M, Flowers L, Krishnamurti U. Programmed Death Ligand-1 Expression Is Associated With Poorer Survival in Anal Squamous Cell Carcinoma. Archives Of Pathology & Laboratory Medicine 2021, 146: 1094-1101. PMID: 34936703, DOI: 10.5858/arpa.2021-0169-oa.Peer-Reviewed Original ResearchConceptsAnal squamous cell carcinomaPD-L1 expressionHIV viral loadTumor proportion scorePD-L1Squamous cell carcinomaOverall survivalCD4 countPrognostic factorsHIV statusViral loadCell carcinomaProportion scoreInvasive anal squamous cell carcinomaMedian cancer-specific survivalIndependent adverse prognostic factorDeath ligand 1 (PD-L1) expressionCancer-specific survivalAdverse prognostic factorLigand 1 expressionSignificant prognostic factorsDeath ligand 1Kaplan-Meier curvesWorse overall survivalLog-rank test
2020
HER2 immunohistochemistry staining positivity is strongly predictive of tumor response to neoadjuvant chemotherapy in HER2 positive breast cancer
Zhao J, Krishnamurti U, Zhang C, Meisel J, Wei Z, Suo A, Aneja R, Li Z, Li X. HER2 immunohistochemistry staining positivity is strongly predictive of tumor response to neoadjuvant chemotherapy in HER2 positive breast cancer. Pathology - Research And Practice 2020, 216: 153155. PMID: 32871536, DOI: 10.1016/j.prp.2020.153155.Peer-Reviewed Original ResearchConceptsHigh HER2/CEP17 ratioHER2/CEP17 ratioTumor responseBreast cancer casesNeoadjuvant HER2CEP17 ratioNeoadjuvant chemotherapyIHC 3Breast cancerCancer casesRCB II/IIIHER2-positive breast cancerHER2 IHC 3Complete pathologic responseResidual cancer burdenSmaller tumor sizePositive breast cancerLow nuclear gradeHER2 copy numberHigh Ki67Pathologic responseCancer burdenExcisional specimensPositive cancersTumor sizeDo High Rates of Atypical Glandular Cells Correlate With Higher Incidence of Disease in a Large Safety Net Hospital.
Kuhn T, Finneran C, Kohut A, Wang E, Birdsong G, Krishnamurti U, Mosunjac M, Tadros T, Oprea G, Avadhani V, Boguslawski S, Karlow S, Schnatz P, Khanna N, Flowers L. Do High Rates of Atypical Glandular Cells Correlate With Higher Incidence of Disease in a Large Safety Net Hospital. Journal Of Lower Genital Tract Disease 2020, 24: 353-357. PMID: 32569024, DOI: 10.1097/lgt.0000000000000556.Peer-Reviewed Original ResearchConceptsAGC Pap testsAbnormal uterine bleedingPap testUterine bleedingHPV positivityHuman papillomavirusLarge safety net hospitalBody mass indexHigh-risk lesionsLow-risk lesionsSafety-net hospitalLow socioeconomic statusBaseline characteristicsEndometrial biopsyMass indexSingle institutionMedical recordsNet hospitalHigh incidencePatientsLesionsSignificant associationHR lesionsBleedingLogistic regressionDetection of crown-like structures in breast adipose tissue and clinical outcomes among African-American and White women with breast cancer
Maliniak M, Cheriyan A, Sherman M, Liu Y, Gogineni K, Liu J, He J, Krishnamurti U, Miller-Kleinhenz J, Ashiqueali R, He J, Yacoub R, McCullough L. Detection of crown-like structures in breast adipose tissue and clinical outcomes among African-American and White women with breast cancer. Breast Cancer Research 2020, 22: 65. PMID: 32552729, PMCID: PMC7298873, DOI: 10.1186/s13058-020-01308-4.Peer-Reviewed Original ResearchConceptsBreast adipose tissueHazard ratioBreast cancerAdipose tissueMultivariable Cox proportional hazards modelsWhite womenCox proportional hazards modelProgression-free survivalMedical record reviewCurrent smoking statusConfidence intervalsProportional hazards modelBenign breast tissueBreast cancer prognosisNon-tumor tissuesCrown-like structuresMulti-racial populationEvidence of associationWorse OSWhite patientsClinical outcomesRecord reviewSmoking statusLifestyle factorsMultivariable modelObesity-associated methylation in breast tumors: a possible link to disparate outcomes?
Do W, Conneely K, Gabram-Mendola S, Krishnamurti U, D’Angelo O, Miller-Kleinhenz J, Gogineni K, Torres M, McCullough L. Obesity-associated methylation in breast tumors: a possible link to disparate outcomes? Breast Cancer Research And Treatment 2020, 181: 135-144. PMID: 32236829, DOI: 10.1007/s10549-020-05605-6.Peer-Reviewed Original ResearchConceptsCause mortalityER statusMultivariable Cox proportional hazards modelsCox proportional hazards modelBreast cancer tumor tissuesBreast cancer outcomesBreast cancer incidenceEstrogen receptor statusBody mass indexPrimary risk factorNon-Hispanic blacksCancer tumor tissuesReceptor statusMass indexCancer outcomesCpG sitesRisk factorsCancer incidenceBreast cancerHazards modelBreast tumorsTumor tissueWhite womenObesityRace disparitiesCombined HER3-EGFR score in triple-negative breast cancer provides prognostic and predictive significance superior to individual biomarkers
Ogden A, Bhattarai S, Sahoo B, Mongan N, Alsaleem M, Green A, Aleskandarany M, Ellis I, Pattni S, Li X, Moreno C, Krishnamurti U, Janssen E, Jonsdottir K, Rakha E, Rida P, Aneja R. Combined HER3-EGFR score in triple-negative breast cancer provides prognostic and predictive significance superior to individual biomarkers. Scientific Reports 2020, 10: 3009. PMID: 32080212, PMCID: PMC7033213, DOI: 10.1038/s41598-020-59514-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntineoplastic AgentsBiomarkers, TumorCohort StudiesErbB ReceptorsFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansMammary Glands, HumanMiddle AgedNeoplasm StagingNF-kappa BPoly (ADP-Ribose) Polymerase-1PrognosisReceptor, ErbB-3Survival AnalysisThioredoxinsTriple Negative Breast NeoplasmsTumor Suppressor Protein p53Diagnosing Anal Squamous Intraepithelial Lesions With and Without p16: An Interobserver Variability Study.
Krishnamurti U, Mohammad M, Monsrud A, Mosunjac M, Oprea G, Hanley K, Tadros T, Flowers L, Mosunjac M. Diagnosing Anal Squamous Intraepithelial Lesions With and Without p16: An Interobserver Variability Study. Journal Of Lower Genital Tract Disease 2020, 24: 69-74. PMID: 31860579, DOI: 10.1097/lgt.0000000000000500.Peer-Reviewed Original Research
2019
Clinicopathologic Factors Associated With Response to Neoadjuvant Anti-HER2–Directed Chemotherapy in HER2-Positive Breast Cancer
Meisel J, Zhao J, Suo A, Zhang C, Wei Z, Taylor C, Aneja R, Krishnamurti U, Li Z, Nahta R, O'Regan R, Li X. Clinicopathologic Factors Associated With Response to Neoadjuvant Anti-HER2–Directed Chemotherapy in HER2-Positive Breast Cancer. Clinical Breast Cancer 2019, 20: 19-24. PMID: 31806448, DOI: 10.1016/j.clbc.2019.09.003.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntineoplastic Combined Chemotherapy ProtocolsBiomarkers, TumorBreastBreast NeoplasmsCarcinoma, Ductal, BreastChemotherapy, AdjuvantDNA Copy Number VariationsDrug Resistance, NeoplasmFeasibility StudiesFemaleHumansLymphocytes, Tumor-InfiltratingMastectomyMiddle AgedNeoadjuvant TherapyPredictive Value of TestsProgression-Free SurvivalReceptor, ErbB-2Receptors, EstrogenReceptors, ProgesteroneTumor BurdenConceptsTumor-infiltrating lymphocytesHER2-positive breast cancerNeoadjuvant therapyHER2/CEP17 ratioBreast cancerClinicopathologic featuresTumor sizeEstrogen receptorKi-67High HER2/CEP17 ratioCEP17 ratioHER2 immunohistochemistry 3Pathologic complete responseProgesterone receptor expressionSmaller tumor sizeBreast cancer responseHigh Ki-67Low estrogen receptorHER2 copy numberRCB-IIPatient ageClinicopathologic factorsComplete responseInitial biopsyExcisional specimensA whole slide image-based machine learning approach to predict ductal carcinoma in situ (DCIS) recurrence risk
Klimov S, Miligy I, Gertych A, Jiang Y, Toss M, Rida P, Ellis I, Green A, Krishnamurti U, Rakha E, Aneja R. A whole slide image-based machine learning approach to predict ductal carcinoma in situ (DCIS) recurrence risk. Breast Cancer Research 2019, 21: 83. PMID: 31358020, PMCID: PMC6664779, DOI: 10.1186/s13058-019-1165-5.Peer-Reviewed Original ResearchConceptsDCIS patientsRecurrence riskDuctal carcinomaScreen-detected breast cancerLong-term outcome dataBreast-conserving surgeryUnmet clinical needNottingham University HospitalsPositive predictive valueAdjuvant radiationIpsilateral recurrenceAdditional therapyMethodsThe cohortHazard ratioLocal recurrenceClinicopathological markersClinicopathological variablesPrimary tumorUniversity HospitalLymphocyte regionBreast cancerOutcome dataBenign ductsPredictive valuePatients
2017
GRB7 Expression and Correlation With HER2 Amplification in Invasive Breast Carcinoma
Bivin W, Yergiyev O, Bunker M, Silverman J, Krishnamurti U. GRB7 Expression and Correlation With HER2 Amplification in Invasive Breast Carcinoma. Applied Immunohistochemistry & Molecular Morphology 2017, 25: 553-558. PMID: 26945445, DOI: 10.1097/pai.0000000000000349.Peer-Reviewed Original ResearchConceptsInvasive breast carcinomaHER2 amplificationHER2 overexpressionER negativityPathologic stageHistologic gradeP53 positivityGRB7 expressionBreast cancerBreast carcinomaInvasive breast cancer correlatesInvasive breast cancerBreast cancer correlatesChromosome 17 copy numberAntiestrogen therapyPR expressionPredictive factorsHER2 expressionCancer correlatesPR testingP53 immunohistochemistryAggressive phenotypeHER2 geneHER2P53 statusHormone Receptor-Positive Breast Cancer Has a Worse Prognosis in Male Than in Female Patients
Li X, Yang J, Krishnamurti U, Huo L, Ward K, O'Regan R, Peng L. Hormone Receptor-Positive Breast Cancer Has a Worse Prognosis in Male Than in Female Patients. Clinical Breast Cancer 2017, 17: 356-366. PMID: 28576631, DOI: 10.1016/j.clbc.2017.03.005.Peer-Reviewed Original ResearchConceptsMale breast carcinomaFemale breast carcinomaHormone receptorsMBC patientsWorse OSOverall survivalBreast carcinomaBreast cancerStage IHormone receptor-positive breast cancerEarly-stage hormone receptorReceptor-positive breast cancerNational Cancer Institute's SurveillanceEnd Results (SEER) databaseWorse overall survivalBreast carcinoma casesSimilar survival ratesMBC subtypesWorse survivalClinicopathologic featuresOverall incidenceResults databaseWorse prognosisHER2 statusFBC patientsPathobiology of human papillomaviruses in human immunodeficiency virus – Infected persons
Krishnamurti U, Unger E. Pathobiology of human papillomaviruses in human immunodeficiency virus – Infected persons. Seminars In Diagnostic Pathology 2017, 34: 364-370. PMID: 28549522, DOI: 10.1053/j.semdp.2017.04.005.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusAcquired Immunodeficiency SyndromeHuman papillomavirusHuman immunodeficiency virus-infected personsCareful epidemiologic studiesMultiple HPV typesVirus-infected personsNegative patientsHPV typesImmunodeficiency syndromeCervical cancerImmunodeficiency virusPrimary preventionViral etiologyHIV epidemicEpidemiologic studiesSurveillance indicatorsLaboratory measuresPapillomavirusDiseasePathobiologyVirus groupDefinitive identificationPatientsHigh frequencyNew Developments in Breast Cancer and Their Impact on Daily Practice in Pathology
Li X, Oprea-Ilies G, Krishnamurti U. New Developments in Breast Cancer and Their Impact on Daily Practice in Pathology. Archives Of Pathology & Laboratory Medicine 2017, 141: 490-498. PMID: 28353377, DOI: 10.5858/arpa.2016-0288-sa.Peer-Reviewed Original ResearchConceptsBreast cancerDaily practiceBreast specimensTriple-negative breast cancerDistinct biological subsetsHER2/neu gene amplificationTumor-infiltrating lymphocytesRadioactive seed localizationAppropriate treatment groupsNovel clinical practicesNeu gene amplificationNeoadjuvant treatmentPathologic evaluationHistopathologic parametersTreatment groupsClinical practiceTherapeutic utilityBiological subsetsCancerMolecular classificationBest treatmentPathologyNew guidelinesSeed localizationGene amplificationMulti-institutional study of nuclear KIFC1 as a biomarker of poor prognosis in African American women with triple-negative breast cancer
Ogden A, Garlapati C, Li X, Turaga R, Oprea-Ilies G, Wright N, Bhattarai S, Mittal K, Wetherilt C, Krishnamurti U, Reid M, Jones M, Gupta M, Osan R, Pattni S, Riaz A, Klimov S, Rao A, Cantuaria G, Rida P, Aneja R. Multi-institutional study of nuclear KIFC1 as a biomarker of poor prognosis in African American women with triple-negative breast cancer. Scientific Reports 2017, 7: 42289. PMID: 28218233, PMCID: PMC5316996, DOI: 10.1038/srep42289.Peer-Reviewed Original ResearchConceptsDistant metastasis-free survivalProgression-free survivalTNBC cellsOverall survivalPoor prognosisBreast cancerTriple-negative breast cancer patientsTriple-negative breast cancerMultivariable Cox modelMetastasis-free survivalWorse overall survivalBreast cancer patientsMulti-institutional studyAA TNBC patientsAfrican AmericansAfrican American womenTNBC patientsIndependent biomarkerPrognostic valueCancer patientsWorse outcomesCox modelTissue microarrayKIFC1 knockdownTNBCTumor-infiltrating lymphocytes are significantly associated with better overall survival and disease-free survival in triple-negative but not estrogen receptor–positive breast cancers
Krishnamurti U, Wetherilt C, Yang J, Peng L, Li X. Tumor-infiltrating lymphocytes are significantly associated with better overall survival and disease-free survival in triple-negative but not estrogen receptor–positive breast cancers. Human Pathology 2017, 64: 7-12. PMID: 28153508, DOI: 10.1016/j.humpath.2017.01.004.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorBiopsyBreast NeoplasmsChemotherapy, AdjuvantDisease ProgressionDisease-Free SurvivalFemaleHumansLogistic ModelsLymphatic MetastasisLymphocytes, Tumor-InfiltratingMastectomyMultivariate AnalysisNeoplasm GradingNeoplasm Recurrence, LocalNeoplasm StagingOdds RatioPredictive Value of TestsProportional Hazards ModelsReceptors, EstrogenRisk FactorsTime FactorsTreatment OutcomeTriple Negative Breast NeoplasmsConceptsTriple-negative breast cancerTumor-infiltrating lymphocytesDisease-free survivalBetter overall survivalLymph node statusOverall survivalBreast cancerNeoadjuvant treatmentLymphovascular invasionEstrogen receptor-positive breast cancerReceptor-positive breast cancerOncotype DX recurrence scoreOncotype DX scorePossible prognostic valueDX recurrence scoreNottingham histologic gradeNeoadjuvant settingTILs correlateNegative associationNode statusPrognostic valueRecurrence scoreHistologic gradePrognostic parametersPathological response