Efficacy and Safety of Ketamine/Esketamine in Bipolar Depression in a Clinical Setting.
Santucci M, Ansari M, Nikayin S, Radhakrishnan R, Rhee T, Wilkinson S. Efficacy and Safety of Ketamine/Esketamine in Bipolar Depression in a Clinical Setting. The Journal Of Clinical Psychiatry 2024, 85 PMID: 39361411, DOI: 10.4088/jcp.24m15376.Peer-Reviewed Original ResearchConceptsBipolar depressionAcute seriesRisk of affective switchDiagnosis of bipolar depressionRefractory bipolar depressionAcute phaseMADRS scoreAffective switchIntranasal esketamineManic episodesBipolar disorderCohort of patientsAttending psychiatristsSource of morbidityEsketamineSample of patientsIV ketamineMaintenance treatmentDepressionClinical responseHeightened riskClinical outcomesMania/hypomaniaKetamineKetamine/esketamineAssociation between cognitive functioning, suicidal ideation and suicide attempts in major depressive disorder, bipolar disorder, schizophrenia and related disorders: A systematic review and meta-analysis
Le G, Wong S, Haikazian S, Johnson D, Badulescu S, Kwan A, Gill H, Di Vincenzo J, Rosenblat J, Mansur R, Teopiz K, Rhee T, Ho R, Liao S, Cao B, Schweinfurth-Keck N, Vinberg M, Grande I, Phan L, d'Andrea G, McIntyre R. Association between cognitive functioning, suicidal ideation and suicide attempts in major depressive disorder, bipolar disorder, schizophrenia and related disorders: A systematic review and meta-analysis. Journal Of Affective Disorders 2024, 365: 381-399. PMID: 39168166, DOI: 10.1016/j.jad.2024.08.057.Peer-Reviewed Original ResearchBipolar disorderCognitive functionSchizoaffective disorderDepressive disorderExecutive functionMental disordersMeasures of cognitive functionSelf-injurious behaviorTreatable mental disorderGlobal executive functioningEffect size of associationSuicidal ideation/suicide attemptTransdiagnostic associationsSize of associationEmotional inhibitionWorking memoryNegative associationCognitive measuresNeurocognitive deficitsSuicidal ideationSuicide riskCognitive disturbancesImpulse controlProcessing speedMDD