2024
Intimomedial tears of the aorta heal by smooth muscle cell-mediated fibrosis without atherosclerosis
Hassab A, Hur D, Vallabhajosyula P, Tellides G, Assi R. Intimomedial tears of the aorta heal by smooth muscle cell-mediated fibrosis without atherosclerosis. JCI Insight 2024, 9: e172437. PMID: 38592807, PMCID: PMC11141924, DOI: 10.1172/jci.insight.172437.Peer-Reviewed Original ResearchConceptsDepartment of SurgerySmooth muscle cellsCellular response to injuryResponse to injuryImmunofluorescence confocal microscopyVessel wall repairPrimary lesionAscending aortaConduit functionAneurysmal diseaseDense fibrosisRadiological signsMural hematomaTear progressionMuscle cellsNon-hemorrhagicErythrocyte extravasationWall repairAortaTear completionInduce atherosclerosisHealed lesionsScattered leukocytesMinimal injuryConclusionThese findings
2021
Quantitative not qualitative histology differentiates aneurysmal from nondilated ascending aortas and reveals a net gain of medial components
Yousef S, Matsumoto N, Dabe I, Mori M, Landry AB, Lee SR, Kawamura Y, Yang C, Li G, Assi R, Vallabhajosyula P, Geirsson A, Moeckel G, Humphrey JD, Tellides G. Quantitative not qualitative histology differentiates aneurysmal from nondilated ascending aortas and reveals a net gain of medial components. Scientific Reports 2021, 11: 13185. PMID: 34162971, PMCID: PMC8222259, DOI: 10.1038/s41598-021-92659-1.Peer-Reviewed Original ResearchConceptsMedial degenerationAortic aneurysmSporadic thoracic aortic aneurysmMedial cell numberCommon histopathological findingThoracic aortic aneurysmSmooth muscle cellsAortic dilatationHistopathological findingsAscending aortaHistopathological criteriaAneurysmal wallLumen dilatationClinical diagnosisMuscle cellsAneurysmsAortaDegenerationDilatationMural cellsMarked overlapElastic lamellaeMedial componentCell numberMedial tissue
2018
Adipose-derived mesenchymal stem cells accelerate diabetic wound healing in a similar fashion as bone marrow-derived cells
Guo J, Hu H, Gorecka J, Bai H, He H, Assi R, Isaji T, Wang T, Setia O, Lopes L, Gu Y, Dardik A. Adipose-derived mesenchymal stem cells accelerate diabetic wound healing in a similar fashion as bone marrow-derived cells. American Journal Of Physiology - Cell Physiology 2018, 315: c885-c896. PMID: 30404559, PMCID: PMC6336941, DOI: 10.1152/ajpcell.00120.2018.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAnimalsBone Marrow CellsCell ProliferationCell SurvivalDiabetes Mellitus, ExperimentalGene Expression Regulation, DevelopmentalHumansMesenchymal Stem Cell TransplantationMesenchymal Stem CellsMiceNeovascularization, PhysiologicPlatelet Endothelial Cell Adhesion Molecule-1Vascular Endothelial Growth Factor AWound HealingConceptsBone marrow-derived mesenchymal stem cellsBiomimetic collagen scaffoldStem cellsDiabetic wound healingMesenchymal stem cellsHuman diabeticsWound healingMouse modelMarrow-derived mesenchymal stem cellsSimilar extentBone marrow-derived cellsNotch signalingHuman diabetic woundsDiabetic C57BL/6 miceAdipose-derived mesenchymal stem cellsCell survivalMarrow-derived cellsEndothelial cell densityDiabetic mouse modelNumber of macrophagesNude mouse modelTissue-derived stem cellsCD31-positive cellsCellular proliferationSmooth muscle cells
2013
The mouse aortocaval fistula recapitulates human arteriovenous fistula maturation
Yamamoto K, Protack CD, Tsuneki M, Hall MR, Wong DJ, Lu DY, Assi R, Williams WT, Sadaghianloo N, Bai H, Miyata T, Madri JA, Dardik A. The mouse aortocaval fistula recapitulates human arteriovenous fistula maturation. AJP Heart And Circulatory Physiology 2013, 305: h1718-h1725. PMID: 24097429, PMCID: PMC3882542, DOI: 10.1152/ajpheart.00590.2013.Peer-Reviewed Original ResearchConceptsArteriovenous fistulaMaturation failureHigh-resolution Doppler ultrasoundArteriovenous fistula maturationFirst animal modelMature arteriovenous fistulaSmooth muscle cellsHuman AVF maturationAVF maturationAortocaval fistulaAVF failureFistula maturationImmediate thrombosisVenous adaptationExcellent patencyDoppler ultrasoundAnimal modelsDay 21Human patientsNeedle punctureDay 42Muscle cellsFistulaArterial environmentFailure