2024
Development of a 31P magnetic resonance spectroscopy technique to quantify NADH and NAD+ at 3 T
Mevenkamp J, Bruls Y, Mancilla R, Grevendonk L, Wildberger J, Brouwers K, Hesselink M, Schrauwen P, Hoeks J, Houtkooper R, Buitinga M, de Graaf R, Lindeboom L, Schrauwen-Hinderling V. Development of a 31P magnetic resonance spectroscopy technique to quantify NADH and NAD+ at 3 T. Nature Communications 2024, 15: 9159. PMID: 39443469, PMCID: PMC11499639, DOI: 10.1038/s41467-024-53292-4.Peer-Reviewed Original ResearchConceptsPhysically active older adultsActive older adultsMetabolic healthHuman skeletal musclePhosphorous magnetic resonance spectroscopySedentary individualsOlder adultsStimulate mitochondrial biogenesisHealthSkeletal muscleMitochondrial biogenesisNAD+Physiological decreaseNADH contentNADHQuantify NADHClinical 3Magnetic resonance spectroscopy techniquesMR sequencesAdultsMeasurement reproducibility
2023
Design and realization of a multi‐coil array for B0 field control in a compact 1.5T head‐only MRI scanner
Theilenberg S, Shang Y, Ghazouani J, Kumaragamage C, Nixon T, McIntyre S, Vaughan J, Parkinson B, Garwood M, de Graaf R, Juchem C. Design and realization of a multi‐coil array for B0 field control in a compact 1.5T head‐only MRI scanner. Magnetic Resonance In Medicine 2023, 90: 1228-1241. PMID: 37145035, PMCID: PMC10330274, DOI: 10.1002/mrm.29692.Peer-Reviewed Original ResearchConceptsMulti-coil arraysMC arraysDuty cycleGeneration capabilityT headNonlinear magnetic fieldHigh duty cycleThermal behaviorBench testingField controlRamp timeResidual imperfectionField generationScanner designMagnetic fieldMC hardwareLinear gradientMRI scannerArrayCapabilityDesignHardwareImage encodingFieldMagnets
2022
Interleaved fluid‐attenuated inversion recovery (FLAIR) MRI and deuterium metabolic imaging (DMI) on human brain in vivo
Liu Y, De Feyter HM, Fulbright RK, McIntyre S, Nixon TW, de Graaf R. Interleaved fluid‐attenuated inversion recovery (FLAIR) MRI and deuterium metabolic imaging (DMI) on human brain in vivo. Magnetic Resonance In Medicine 2022, 88: 28-37. PMID: 35225375, PMCID: PMC9924309, DOI: 10.1002/mrm.29196.Peer-Reviewed Original Research
2020
ECLIPSE utilizing gradient‐modulated offset‐independent adiabaticity (GOIA) pulses for highly selective human brain proton MRSI
Kumaragamage C, De Feyter HM, Brown P, McIntyre S, Nixon TW, de Graaf R. ECLIPSE utilizing gradient‐modulated offset‐independent adiabaticity (GOIA) pulses for highly selective human brain proton MRSI. NMR In Biomedicine 2020, 34: e4415. PMID: 33001485, PMCID: PMC9472321, DOI: 10.1002/nbm.4415.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsBrainComputer SimulationFemaleHumansLipidsMagnetic Resonance ImagingMalePhantoms, ImagingProtonsRadio WavesWaterDynamic multicoil technique (DYNAMITE) MRI on human brain
Juchem C, Theilenberg S, Kumaragamage C, Mullen M, DelaBarre L, Adriany G, Brown PB, McIntyre S, Nixon TW, Garwood M, de Graaf R. Dynamic multicoil technique (DYNAMITE) MRI on human brain. Magnetic Resonance In Medicine 2020, 84: 2953-2963. PMID: 32544274, PMCID: PMC8168279, DOI: 10.1002/mrm.28323.Peer-Reviewed Original ResearchConceptsGradient coilsConventional gradient coilsField controlMagnetic field gradientImage fidelityShim systemBiot-Savart lawFirst realizationCylindrical surfaceCoil technologyGradient technologyImage distortion correctionGradient fieldGradient errorsField imperfectionsHuman headCoilGeometric deformationMR environmentField gradientLinear xDistortion correctionResolution phantomSpatial encodingNumerical integration
2019
On the magnetic field dependence of deuterium metabolic imaging
de Graaf R, Hendriks AD, Klomp DWJ, Kumaragamage C, Welting D, de Castro C, Brown PB, McIntyre S, Nixon TW, Prompers JJ, De Feyter HM. On the magnetic field dependence of deuterium metabolic imaging. NMR In Biomedicine 2019, 33: e4235. PMID: 31879985, PMCID: PMC7141779, DOI: 10.1002/nbm.4235.Peer-Reviewed Original Research
2018
Elliptical localization with pulsed second‐order fields (ECLIPSE) for robust lipid suppression in proton MRSI
de Graaf R, Brown PB, De Feyter HM, McIntyre S, Nixon TW. Elliptical localization with pulsed second‐order fields (ECLIPSE) for robust lipid suppression in proton MRSI. NMR In Biomedicine 2018, 31: e3949. PMID: 29985532, PMCID: PMC6108906, DOI: 10.1002/nbm.3949.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsBrainHumansLipidsMagnetic Resonance ImagingPhantoms, ImagingProton Magnetic Resonance SpectroscopyMinimum echo time PRESS‐based proton observed carbon edited (POCE) MRS in rat brain using simultaneous editing and localization pulses
Kumaragamage C, Madularu D, Mathieu AP, Lupinsky D, de Graaf R, Near J. Minimum echo time PRESS‐based proton observed carbon edited (POCE) MRS in rat brain using simultaneous editing and localization pulses. Magnetic Resonance In Medicine 2018, 80: 1279-1288. PMID: 29427395, DOI: 10.1002/mrm.27119.Peer-Reviewed Original Research
2017
Selective proton‐observed, carbon‐edited (selPOCE) MRS method for measurement of glutamate and glutamine 13C‐labeling in the human frontal cortex
De Feyter H, Herzog RI, Steensma BR, Klomp DWJ, Brown PB, Mason GF, Rothman DL, de Graaf R. Selective proton‐observed, carbon‐edited (selPOCE) MRS method for measurement of glutamate and glutamine 13C‐labeling in the human frontal cortex. Magnetic Resonance In Medicine 2017, 80: 11-20. PMID: 29134686, PMCID: PMC5876108, DOI: 10.1002/mrm.27003.Peer-Reviewed Original ResearchMeasurement of lipid composition in human skeletal muscle and adipose tissue with 1H‐MRS homonuclear spectral editing
Lindeboom L, de Graaf R. Measurement of lipid composition in human skeletal muscle and adipose tissue with 1H‐MRS homonuclear spectral editing. Magnetic Resonance In Medicine 2017, 79: 619-627. PMID: 28474367, DOI: 10.1002/mrm.26740.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAdultAlgorithmsHumansLipidsMaleMiddle AgedMuscle, SkeletalPhantoms, ImagingProton Magnetic Resonance SpectroscopyConceptsAdipose tissueProton magnetic resonance spectroscopySkeletal muscleH-MRSAccumulation of triglyceridesInvasive biopsyMetabolic derangementsEctopic fatInsulin resistanceCardiovascular diseaseMetabolic diseasesMEGA-sLASER sequenceIn vivoNonadipose tissuesLipid resonancesSpectral editingPolyunsaturated fatty acidsHuman skeletal muscleMagnetic resonance spectroscopyLipid storesLipid compositionAdiposeSpectral resolutionTissuePhantom experiments
2013
In vivo GABA T2 determination with J‐refocused echo time extension at 7 T
Andreychenko A, Klomp D, de Graaf R, Luijten P, Boer V. In vivo GABA T2 determination with J‐refocused echo time extension at 7 T. NMR In Biomedicine 2013, 26: 1596-1601. PMID: 23893556, DOI: 10.1002/nbm.2997.Peer-Reviewed Original ResearchMeSH KeywordsCreatineGamma-Aminobutyric AcidHumansMagnetic Resonance ImagingPhantoms, ImagingSignal Processing, Computer-AssistedTime FactorsConceptsCoupled spin systemsSpin systemsRelaxation timeEcho timeJ-coupled spinsT. A methodMultiple echo timesEdited signalSpectral editing techniquesShort echo timeT2 decay curvesT2 decayJ-couplingMEGA-sLASERTarget resonancesJ-modulationShape correctionEdited spectraDecay curvesResonanceT2 determinationT2 relaxation timesSpinSignal intensityDecay
1996
Single‐shot, B1‐insensitive slice selection with a gradient‐modulated adiabatic pulse, BISS‐8
de Graaf R, Nicolay K, Garwood M. Single‐shot, B1‐insensitive slice selection with a gradient‐modulated adiabatic pulse, BISS‐8. Magnetic Resonance In Medicine 1996, 35: 652-657. PMID: 8722815, DOI: 10.1002/mrm.1910350505.Peer-Reviewed Original Research