2020
B cell-intrinsic TLR9 expression is protective in murine lupus
Tilstra JS, John S, Gordon RA, Leibler C, Kashgarian M, Bastacky S, Nickerson KM, Shlomchik MJ. B cell-intrinsic TLR9 expression is protective in murine lupus. Journal Of Clinical Investigation 2020, 130: 3172-3187. PMID: 32191633, PMCID: PMC7260024, DOI: 10.1172/jci132328.Peer-Reviewed Original ResearchConceptsToll-like receptor 9Systemic lupus erythematosusTLR9 deficiencyTLR9 expressionDendritic cellsB cellsPlasmacytoid dendritic cellsAnti-nucleosome antibodiesLupus erythematosusAutoantibody productionMurine lupusSLE pathogenesisTLR9 signalsReceptor 9Cell type-specific effectsType-specific effectsDisease pathogenesisTherapeutic potentialSelective deletionDiseaseNonredundant roleNephritisLupusPathogenesisDeficiency
1985
Pathology of Small Blood Vessel Disease in Hypertension
Kashgarian M. Pathology of Small Blood Vessel Disease in Hypertension. American Journal Of Kidney Diseases 1985, 5: a104-a110. PMID: 2581443, DOI: 10.1016/s0272-6386(85)80072-x.Peer-Reviewed Original ResearchConceptsHyaline arteriolosclerosisPerpetuation of hypertensionSmall blood vessel diseaseBlood vessel diseasesArteriolar diseaseMyointimal hyperplasiaVessel diseasePathogenic rolePathophysiologic consequencesAnatomic correlatesHypertensionTransmural pressureArteriolosclerosisLesionsDiseaseExtracellular matrixArteriolonecrosisHyperplasiaArteriolesPathogenesisTherapyPathology