2022
Podocyte VEGF-A Knockdown Induces Diffuse Glomerulosclerosis in Diabetic and in eNOS Knockout Mice
Veron D, Aggarwal PK, Li Q, Moeckel G, Kashgarian M, Tufro A. Podocyte VEGF-A Knockdown Induces Diffuse Glomerulosclerosis in Diabetic and in eNOS Knockout Mice. Frontiers In Pharmacology 2022, 12: 788886. PMID: 35280251, PMCID: PMC8906751, DOI: 10.3389/fphar.2021.788886.Peer-Reviewed Original ResearchDiabetic kidney diseaseGlomerular filtration rateDiffuse glomerulosclerosisDiabetic miceRenal failureNitric oxideMassive proteinuriaKnockout miceEndothelial nitric oxide synthase knockout miceNitric oxide synthase knockout miceNormal glomerular filtration rateAbsence of diabetesENOS knockout miceSynthase knockout miceVascular endothelial growth factorTargetable molecular mechanismsFoot process effacementEndothelial growth factorAbnormal S-nitrosylationArteriolar hyalinosisGFR lossMild proteinuriaSevere proteinuriaKidney diseaseUrinary excretion
2020
Urine interleukin-9 and tumor necrosis factor-α for prognosis of human acute interstitial nephritis
Moledina DG, Wilson FP, Kukova L, Obeid W, Luciano R, Kuperman M, Moeckel GW, Kashgarian M, Perazella MA, Cantley LG, Parikh CR. Urine interleukin-9 and tumor necrosis factor-α for prognosis of human acute interstitial nephritis. Nephrology Dialysis Transplantation 2020, 36: 1851-1858. PMID: 33125471, PMCID: PMC8476079, DOI: 10.1093/ndt/gfaa169.Peer-Reviewed Original ResearchConceptsAcute interstitial nephritisTumor necrosis factorCorticosteroid useIL-9Interstitial nephritisNecrosis factorAcute kidney injuryIL-9 levelsGlomerular filtration rateSubset of patientsCohort of participantsImmunosuppressive therapyTubulointerstitial infiltratesKidney injuryMedian eGFRKidney functionUrine biomarkersInterstitial fibrosisFiltration rateHistological featuresClinical trialsInterleukin-9PatientsEGFRComplete data
1986
Progressive Glomerular Sclerosis in Experimental Antiglomerular Basement Membrane Glomerulonephritis
Foellmer H, Sterzel R, Kashgarian M. Progressive Glomerular Sclerosis in Experimental Antiglomerular Basement Membrane Glomerulonephritis. American Journal Of Kidney Diseases 1986, 7: 5-11. PMID: 3510536, DOI: 10.1016/s0272-6386(86)80050-6.Peer-Reviewed Original ResearchConceptsGlomerular filtration rateAntiglomerular basement membrane glomerulonephritisProgressive glomerular sclerosisGlomerular sclerosisPara-aminohippuric acidGlomerular hypercellularityFiltration fractionWistar ratsInitial inflammatory changesNormal renal clearanceIntrinsic glomerular cellsChronic glomerulosclerosisRenal insufficiencyInflammatory changesAcute phaseChronic phaseSignificant proteinuriaFiltration rateLeukocytic infiltrationCrescent formationFunctional abnormalitiesSclerotic processRenal clearanceGlomerular cellsGlomerulonephritis
1977
Renal function and cortical blood flow during the recovery phase of acute renal failure
Siegel N, Gunstream S, Handler R, Kashgarian M. Renal function and cortical blood flow during the recovery phase of acute renal failure. Kidney International 1977, 12: 199-204. PMID: 926611, DOI: 10.1038/ki.1977.101.Peer-Reviewed Original ResearchConceptsTotal renal blood flowGlomerular filtration rateAcute renal failureCortical blood flowRenal failureRenal functionBlood flowSham-injected control animalsOuter cortexOuter cortical perfusionRenal blood flowRecovery phaseCortical perfusionTubular functionSignificant diuresisFiltration rateInulin clearanceControl animalsDay 4Control valuesAbsolute perfusionProgressive improvementCortexEarly recovery phaseParallel increaseRenal cortical blood flow distribution in obstructive nephropathy in rats.
Siegel N, Feldman R, Lytton B, Hayslett J, Kashgarian M. Renal cortical blood flow distribution in obstructive nephropathy in rats. Circulation Research 1977, 40: 379-384. PMID: 844151, DOI: 10.1161/01.res.40.4.379.Peer-Reviewed Original ResearchConceptsCortical blood flow distributionBilateral ureteral occlusionUnilateral ureteral occlusionRenal blood flowGlomerular filtration rateOuter cortical perfusionBlood flow distributionCortical perfusionObstructive nephropathyUreteral occlusionRenal cortical blood flow distributionRelease of obstructionIntrarenal hemodynamicsCortical ischemiaUUO ratsRapid normalizationFiltration ratePostobstructive diuresisBlood flowComplete returnRapid returnObstructionRatsNormal patternNephropathy
1974
Compensatory adaptation of structure and function following progressive renal ablation
Kaufman J, DiMeola H, Siegel N, Lytton B, Kashgarian M, Hayslett J. Compensatory adaptation of structure and function following progressive renal ablation. Kidney International 1974, 6: 10-17. PMID: 4419711, DOI: 10.1038/ki.1974.72.Peer-Reviewed Original ResearchConceptsRenal ablationRenal tissueNephron glomerular filtration rateCompensatory adaptationGlomerular filtration rateClearance of inulinRenal insufficiencyUninephrectomized ratsFour-week intervalsFiltration rateRenal massesGroup BGroup AControl animalsGroup CLE ratsFunctional changesMass of tissueSegmental lossRatsSurgeryAdaptive changesAblationClearanceTissue
1971
Accelerated reabsorption in the proximal tubule produced by volume depletion
Weiner M, Weinman E, Kashgarian M, Hayslett J. Accelerated reabsorption in the proximal tubule produced by volume depletion. Journal Of Clinical Investigation 1971, 50: 1379-1385. PMID: 5090054, PMCID: PMC292075, DOI: 10.1172/jci106620.Peer-Reviewed Original ResearchConceptsProximal tubulesFiltration rateVolume depletionIntrinsic reabsorptive capacitySodium-free dietGlomerular filtration rateProximal fluid reabsorptionAdministration of furosemideReabsorption of fluidTechnique of micropunctureAldosterone secretionRenal responseSodium depletionDistal tubulesReabsorptive capacityBody weightChronic depletionFluid reabsorptionMarked fallExtracellular volumePlasma volumeClinical phenomenaReabsorptionTubulesPresent experiments
1968
Functional correlates of compensatory renal hypertrophy
Hayslett J, Kashgarian M, Epstein F. Functional correlates of compensatory renal hypertrophy. Journal Of Clinical Investigation 1968, 47: 774-782. PMID: 5641618, PMCID: PMC297228, DOI: 10.1172/jci105772.Peer-Reviewed Original ResearchConceptsCompensatory renal hypertrophyProximal tubulesDistal tubulesRenal hypertrophyCompensatory hypertrophyTubular volumeFunctional correlatesGlomerular filtration rate
1967
Changes in Proximal and Distal Tubular Reabsorption Produced by Rapid Expansion of Extracellular Fluid*
Hayslett J, Kashgarian M, Epstein F. Changes in Proximal and Distal Tubular Reabsorption Produced by Rapid Expansion of Extracellular Fluid*. Journal Of Clinical Investigation 1967, 46: 1254-1263. PMID: 6027087, PMCID: PMC297124, DOI: 10.1172/jci105618.Peer-Reviewed Original ResearchConceptsTubular reabsorptionTubular diameterDistal tubular reabsorptionGlomerular filtration rateProximal tubular reabsorptionAdministration of aldosteroneLoop of HenleAcute infusionFiltration rateRenal contentSaline infusionGlomerular filtrationSegments of tubulesIsotonic salineProximal tubulesExcretion of saltTubular flowReabsorptionExtracellular fluidInfusionTubulesInterstitial volumeRatsTransit timeAldosterone