2022
Hypoconnectivity between anterior insula and amygdala associates with future vulnerabilities in social development in a neurodiverse sample of neonates
Scheinost D, Chang J, Lacadie C, Brennan-Wydra E, Foster R, Boxberger A, Macari S, Vernetti A, Constable RT, Ment LR, Chawarska K. Hypoconnectivity between anterior insula and amygdala associates with future vulnerabilities in social development in a neurodiverse sample of neonates. Scientific Reports 2022, 12: 16230. PMID: 36171268, PMCID: PMC9517994, DOI: 10.1038/s41598-022-20617-6.Peer-Reviewed Original ResearchMeSH KeywordsAmygdalaBrainBrain MappingFemaleHumansInfantInfant, NewbornMagnetic Resonance ImagingNeural PathwaysPregnancySocial ChangeConceptsFirst Year InventoryAnterior insulaFunctional connectivityMaternal mental health factorsLeft anterior insulaState functional connectivityMental health factorsSubsample of participantsPostmenstrual ageSalience networkFamily historySocial domainsNeural circuitryAutismSocial behaviorBrain imagingHigher likelihoodInsulaSocial developmentHypoconnectivityExploratory analysisThird trimesterFuture onsetHealth factorsRisk score
2021
Functional Connectivity for the Language Network in the Developing Brain: 30 Weeks of Gestation to 30 Months of Age
Scheinost D, Chang J, Lacadie C, Brennan-Wydra E, Constable RT, Chawarska K, Ment LR. Functional Connectivity for the Language Network in the Developing Brain: 30 Weeks of Gestation to 30 Months of Age. Cerebral Cortex 2021, 32: 3289-3301. PMID: 34875024, PMCID: PMC9340393, DOI: 10.1093/cercor/bhab415.Peer-Reviewed Original ResearchMeSH KeywordsBrainBrain MappingCross-Sectional StudiesFemaleHumansInfant, NewbornLanguageMagnetic Resonance ImagingPregnancyConceptsWeeks of gestationFirst postnatal monthMonths of agePostnatal monthFunctional connectivityWernicke's areaWeeks postmenstrual ageLanguage networkResting-state fMRI dataPostmenstrual ageFetal onsetInterhemispheric connectionsIntrahemispheric connectionsPrimary analysisOlder infantsNeurobehavioral disordersSecondary analysisGestationCross-sectional dataMonthsBrocaUnique participantsWeeksSignificant increaseFunctional connectionsAssociations of parental birth characteristics with autism spectrum disorder (ASD) risk in their offspring: a population-based multigenerational cohort study in Denmark
Xiao J, Gao Y, Yu Y, Toft G, Zhang Y, Luo J, Xia Y, Chawarska K, Olsen J, Li J, Liew Z. Associations of parental birth characteristics with autism spectrum disorder (ASD) risk in their offspring: a population-based multigenerational cohort study in Denmark. International Journal Of Epidemiology 2021, 50: 485-495. PMID: 33411909, PMCID: PMC8128455, DOI: 10.1093/ije/dyaa246.Peer-Reviewed Original ResearchMeSH KeywordsAutism Spectrum DisorderCohort StudiesDenmarkFemaleHumansInfant, NewbornMaleParentsPregnancyPremature BirthRisk FactorsConceptsBirth characteristicsAutism spectrum disorder (ASD) riskCohort studyOdds ratioNationwide register-based cohort studySociodemographic factorsRegister-based cohort studyOffspring of mothersConfidence intervalsASD riskHealth-related factorsExposure risk factorsDisorder riskLogistic regression modelsOffspring of parentsPerinatal factorsPreterm birthFather-child pairsLow birthweightVery pretermEpidemiological evidenceRisk factorsHigh riskElevated riskPaternal factors
2018
Among Children Born Extremely Preterm a Higher Level of Circulating Neurotrophins Is Associated with Lower Risk of Cognitive Impairment at School Age
Kuban K, Heeren T, O'Shea T, Joseph R, Fichorova R, Douglass L, Jara H, Frazier J, Hirtz D, Taylor H, Rollins J, Paneth N, Investigators E, Ware J, Coster T, Hanson B, Wilson R, McGhee K, Lee P, Asgarian A, Sadhwani A, Perrin E, Neger E, Mattern K, Walkowiak J, Barron S, Shah B, Singh R, Smith A, Klein D, McQuiston S, Venuti L, Powers B, Foley A, Dessureau B, Wood M, Damon-Minow J, Ehrenkranz R, Benjamin J, Romano E, Tsatsanis K, Chawarska K, Kim S, Dieterich S, Bearrs K, Peters N, Brown P, Ansusinha E, Waldrep E, Friedman J, Hounshell G, Allred D, Engelke S, Darden-Saad N, Stainback G, Warner D, Wereszczak J, Bernhardt J, McKeeman J, Meyer E, Pastyrnak S, Rathbun J, Nota S, Crumb T, Lenski M, Weiland D, Lloyd M, Hunter S, Msall M, Ramoskaite R, Wiggins S, Washington K, Martin R, Prendergast B, Scott M, Klarr J, Kring B, DeRidder J, Vogt K, Yamamoto H, Ryan S, Junaid D, Dawood H, Beatty N, Luu N, Tang V, Sassi R, Pasicznyk J. Among Children Born Extremely Preterm a Higher Level of Circulating Neurotrophins Is Associated with Lower Risk of Cognitive Impairment at School Age. The Journal Of Pediatrics 2018, 201: 40-48.e4. PMID: 30029870, PMCID: PMC6684153, DOI: 10.1016/j.jpeds.2018.05.021.Peer-Reviewed Original ResearchConceptsWeeks of lifeNeurotrophic proteinsSevere cognitive impairmentBlood levelsCognitive impairmentInflammatory proteinLower riskBrain-derived neurotrophic factorNeonatal blood specimensProtein blood levelsHigh blood levelsAdverse cognitive outcomesElevated blood levelsLow Gestational Age Newborn StudyNormal T cellsYears of ageHigh exposureFunction testsNeurotrophic factorCognitive function levelT cellsReduced riskMultinomial logistic regressionElevated proteinBlood specimensHand Preference and Cognitive, Motor, and Behavioral Functioning in 10-Year-Old Extremely Preterm Children
Burnett A, Anderson P, Joseph R, Allred E, O'Shea T, Kuban K, Leviton A, Investigators E, Shah B, Singh R, Smith A, Klein D, McQuiston S, Rollins J, Douglass L, Ware J, Coster T, Henson B, Wilson R, McGhee K, Lee P, Asgarian A, Sadhwani A, Perrin E, Neger E, Mattern K, Walkowiak J, Barron S, Frazier J, Venuti L, Powers B, Foley A, Dessureau B, Wood M, Damon-Minow J, Ehrenkranz R, Benjamin J, Romano E, Tsatsanis K, Chawarska K, Kim S, Dieterich S, Bearrs K, Peters N, Brown P, Ansusinha E, Waldrep E, Friedman J, Hounshell G, Allred D, Engelke S, Darden-Saad N, Stainback G, Warner D, Wereszczak J, Bernhardt J, McKeeman J, Meyer E, Pastyrnak S, Burdo-Hartman W, Rathbun J, Nota S, Crumb T, Lenski M, Weiland D, Lloyd M, Hunter S, Msall M, Ramoskaite R, Wiggins S, Washington K, Martin R, Prendergast B, Scott M, Klarr J, Kring B, DeRidder J, Vogt K. Hand Preference and Cognitive, Motor, and Behavioral Functioning in 10-Year-Old Extremely Preterm Children. The Journal Of Pediatrics 2018, 195: 279-282.e3. PMID: 29336793, PMCID: PMC5869125, DOI: 10.1016/j.jpeds.2017.11.056.Peer-Reviewed Original Research
2017
Antecedents of Screening Positive for Attention Deficit Hyperactivity Disorder in Ten-Year-Old Children Born Extremely Preterm
Leviton A, Hooper S, Hunter S, Scott M, Allred E, Joseph R, O'Shea T, Kuban K, Investigators E, Ware J, Coster T, Henson B, Wilson R, McGhee K, Lee P, Asgarian A, Sadhwani A, Perrin E, Neger E, Mattern K, Walkowiak J, Barron S, Frazier J, Venuti L, Powers B, Foley A, Dessureau B, Wood M, Damon-Minow J, Ehrenkranz R, Benjamin J, Romano E, Tsatsanis K, Chawarska K, Kim S, Dieterich S, Bearrs K, O'Shea T, Peters N, Brown P, Ansusinha E, Waldrep E, Friedman J, Hounshell G, Allred D, Engelke S, Darden-Saad N, Stainback G, Warner D, Wereszczak J, Bernhardt J, McKeeman J, Meyer E, Pastyrnak S, Burdo-Hartman W, Rathbun J, Nota S, Crumb T, Lenski M, Weiland D, Lloyd M, Hunter S, Msall M, Ramoskaite R, Wiggins S, Washington K, Martin R, Prendergast B, Scott M, Klarr J, Kring B, DeRidder J, Vogt K. Antecedents of Screening Positive for Attention Deficit Hyperactivity Disorder in Ten-Year-Old Children Born Extremely Preterm. Pediatric Neurology 2017, 81: 25-30. PMID: 29523493, PMCID: PMC5903941, DOI: 10.1016/j.pediatrneurol.2017.12.010.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderDeficit hyperactivity disorderRisk profileHyperactivity disorderRisk factorsLow socioeconomic stateLower gestational ageYoung maternal ageLow birth weightRetinopathy of prematuritySignificant risk factorsWeeks of gestationParent reportChild Symptom Inventory-4Attention deficit hyperactivity disorder (ADHD) diagnosisPostnatal day sevenAntibiotic receiptSeizure prophylaxisMaternal obesityMaternal smokingGestational ageMechanical ventilationBirth weightMaternal ageBrain scansNeurocognitive Outcomes at 10 Years of Age in Extremely Preterm Newborns with Late-Onset Bacteremia
Bright H, Babata K, Allred E, Erdei C, Kuban K, Joseph R, O'Shea T, Leviton A, Dammann O, Investigators E, Ware J, Coster T, Hanson B, Wilson R, McGhee K, Lee P, Asgarian A, Sadhwani A, Perrin E, Neger E, Mattern K, Walkowiak J, Barron S, Shah B, Singh R, Smith A, Klein D, McQuiston S, Venuti L, Powers B, Foley A, Dessureau B, Wood M, Damon-Minow J, Ehrenkranz R, Benjamin J, Romano E, Tsatsanis K, Chawarska K, Kim S, Dieterich S, Bearrs K, Peters N, Brown P, Ansusinha E, Waldrep E, Friedman J, Hounshell G, Allred D, Engelke S, Darden-Saad N, Stainback G, Warner D, Wereszczak J, Bernhardt J, McKeeman J, Meyer E, Pastyrnak S, Rathbun J, Nota S, Crumb T, Lenski M, Weiland D, Lloyd M, Hunter S, Msall M, Ramoskaite R, Wiggins S, Washington K, Martin R, Prendergast B, Scott M, Klarr J, Kring B, DeRidder J, Vogt K. Neurocognitive Outcomes at 10 Years of Age in Extremely Preterm Newborns with Late-Onset Bacteremia. The Journal Of Pediatrics 2017, 187: 43-49.e1. PMID: 28526224, PMCID: PMC5533634, DOI: 10.1016/j.jpeds.2017.04.045.Peer-Reviewed Original ResearchConceptsLate-onset bacteremiaLow gestational age newbornsGeneral cognitive abilityNeurocognitive outcomesGestational age newbornsYears of agePostnatal week 2Age 10 yearsExtremely Preterm NewbornsCognitive abilitiesExecutive functionAge newbornsNeurocognitive limitationsLower IQWeek 2Academic achievementNeurocognitive functionBirth weight z-scoreEvidence of bacteremiaLower gestational ageWeight z-scoreDefinite bacteremiaWeeks of gestationMotor domainLate bacteremiaThe Relationship of Maternal Prepregnancy Body Mass Index and Pregnancy Weight Gain to Neurocognitive Function at Age 10 Years among Children Born Extremely Preterm
Jensen E, van der Burg J, O'Shea T, Joseph R, Allred E, Heeren T, Leviton A, Kuban K, Investigators E, Shah B, Singh R, Smith A, Klein D, McQuiston S, Rollins J, Douglass L, Ware J, Coster T, Henson B, Wilson R, McGhee K, Lee P, Asgarian A, Sadhwani A, Perrin E, Neger E, Mattern K, Walkowiak J, Barron S, Frazier J, Venuti L, Powers B, Foley A, Dessureau B, Wood M, Damon-Minow J, Ehrenkranz R, Benjamin J, Romano E, Tsatsanis K, Chawarska K, Kim S, Dieterich S, Bearrs K, O'Shea T, Peters N, Brown P, Ansusinha E, Waldrep E, Friedman J, Hounshell G, Allred D, Engelke S, Darden-Saad N, Stainback G, Warner D, Wereszczak J, Bernhardt J, McKeeman J, Meyer E, Pastyrnak S, Burdo-Hartman W, Rathbun J, Nota S, Crumb T, Lenski M, Weiland D, Lloyd M, Hunter S, Msall M, Ramoskaite R, Wiggins S, Washington K, Martin R, Prendergast B, Scott M, Klarr J, Kring B, DeRidder J, Vogt K. The Relationship of Maternal Prepregnancy Body Mass Index and Pregnancy Weight Gain to Neurocognitive Function at Age 10 Years among Children Born Extremely Preterm. The Journal Of Pediatrics 2017, 187: 50-57.e3. PMID: 28341527, PMCID: PMC5533624, DOI: 10.1016/j.jpeds.2017.02.064.Peer-Reviewed Original ResearchConceptsPrepregnancy body mass indexBody mass indexMaternal prepregnancy body mass indexPregnancy weight gainMass indexNeurocognitive functionWeight gainCohort of infantsMaternal prepregnancy obesityLower scoresYears of ageAge 10 yearsFine motor controlMaternal obesityPrepregnancy weightProspective multicenterCohort studyPrepregnancy obesitySingleton pregnanciesSchool-aged childrenNeurocognitive evaluationStudy participantsBehavioral interventionsTen-year-old childrenExpression assessment
2016
Predictive Validity of the Modified Checklist for Autism in Toddlers (M-CHAT) Born Very Preterm
Kim SH, Joseph RM, Frazier JA, O'Shea TM, Chawarska K, Allred EN, Leviton A, Kuban KK, Investigators E. Predictive Validity of the Modified Checklist for Autism in Toddlers (M-CHAT) Born Very Preterm. The Journal Of Pediatrics 2016, 178: 101-107.e2. PMID: 27592094, PMCID: PMC5165696, DOI: 10.1016/j.jpeds.2016.07.052.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderBehavioral dysregulationM-CHATModified ChecklistCognitive impairmentPredictive validityGold standard diagnostic instrumentsStandard diagnostic instrumentsAge 2 yearsASD diagnosisSocioeconomic statusSpectrum disorderPreterm toddlersAge 24 monthsPreterm childrenToddlersAutismLow gestational age newbornsImpairmentSensorimotorDiagnostic instrumentAge 10 yearsVision impairmentChildrenChecklistProspective Longitudinal Studies of Infant Siblings of Children With Autism: Lessons Learned and Future Directions
Szatmari P, Chawarska K, Dawson G, Georgiades S, Landa R, Lord C, Messinger DS, Thurm A, Halladay A. Prospective Longitudinal Studies of Infant Siblings of Children With Autism: Lessons Learned and Future Directions. Journal Of The American Academy Of Child & Adolescent Psychiatry 2016, 55: 179-187. PMID: 26903251, PMCID: PMC4871151, DOI: 10.1016/j.jaac.2015.12.014.Peer-Reviewed Original Research
2014
Early Generalized Overgrowth in Autism Spectrum Disorder: Prevalence Rates, Gender Effects, and Clinical Outcomes
Campbell DJ, Chang J, Chawarska K. Early Generalized Overgrowth in Autism Spectrum Disorder: Prevalence Rates, Gender Effects, and Clinical Outcomes. Journal Of The American Academy Of Child & Adolescent Psychiatry 2014, 53: 1063-1073.e5. PMID: 25245350, PMCID: PMC4173120, DOI: 10.1016/j.jaac.2014.07.008.Peer-Reviewed Original ResearchMeSH KeywordsAutism Spectrum DisorderBiomarkersChild, PreschoolFemaleHeadHumansInfantInfant, NewbornMalePrevalenceSex FactorsTorsoConceptsClinical outcomesGeneralized overgrowthEarly growth abnormalitiesAutism spectrum disorderCommunity controlsEarly postnatal periodYears of ageAtypical brain developmentHead circumferencePostnatal periodPrevalence ratesSpectrum disorderEarly overgrowthSymptom severityBrain developmentPostnatal overgrowthSomatic overgrowthGrowth abnormalitiesOptimal outcomesBody overgrowthGender effectsOutcomesEarly headAbnormalitiesPrevalence