2024
The nature of chronic rejection after lung transplantation: a murine orthotopic lung transplant study
Heigl T, Kaes J, Aelbrecht C, Serré J, Yamada Y, Geudens V, Van Herck A, Vanstapel A, Sacreas A, Ordies S, Frick A, Gimenez B, Van Slambrouck J, Beeckmans H, Oztürk N, Orlitova M, Vaneylen A, Claes S, Schols D, Velde G, Schupp J, Kaminski N, Boesch M, Korf H, van der Merwe S, Dupont L, Vanoirbeek J, Godinas L, Van Raemdonck D, Janssens W, Gayan-Ramirez G, Ceulemans L, McDonough J, Verbeken E, Vos R, Vanaudenaerde B. The nature of chronic rejection after lung transplantation: a murine orthotopic lung transplant study. Frontiers In Immunology 2024, 15: 1369536. PMID: 38736881, PMCID: PMC11084670, DOI: 10.3389/fimmu.2024.1369536.Peer-Reviewed Original ResearchConceptsChronic lung allograft dysfunctionChronic rejectionLung transplantationSingle cell RNASingle cell RNA profilingOrthotopic left lung transplantationComplications post-transplantationLung allograft dysfunctionMouse lung transplantationLeft lung transplantationLung transplantation studiesAllograft dysfunctionPleural infiltrationPost-transplantationBronchiolitis obliteransInnate inflammationChronic complicationsPrimary onsetEndothelial destructionTransplantationDay 7Immunological perspectiveArterial responseTransplantation studiesLung
2022
Feasibility of Prolonged Calcineurin-Inhibitor Free Immunosuppression After Lung Transplantation - A Retrospective Single Center Analysis
Gottlieb J, Valtin C, Fischer B, Schupp J, Golpon H. Feasibility of Prolonged Calcineurin-Inhibitor Free Immunosuppression After Lung Transplantation - A Retrospective Single Center Analysis. The Journal Of Heart And Lung Transplantation 2022, 41: s421. DOI: 10.1016/j.healun.2022.01.1061.Peer-Reviewed Original ResearchProliferation signal inhibitorsCalcineurin inhibitor-free immunosuppressionChronic lung allograft dysfunctionRetrospective single-center analysisSingle-center analysisFree immunosuppressionCurative intentionMedian glomerular filtration rateCenter analysisCNI-free immunosuppressionLung allograft dysfunctionTriple-drug regimenGlomerular filtration rateNon-malignant indicationsAllograft dysfunctionEvaluable patientsIS regimenLung transplantationTriple regimenNeurological complicationsPalliative settingDrug regimenInduction agentCase reportFiltration rate