2024
Growth characteristics of HCT116 xenografts lacking asparagine synthetase vary according to sex
Aladelokun O, Lu L, Zheng J, Yan H, Jain A, Gibson J, Khan S, Johnson C. Growth characteristics of HCT116 xenografts lacking asparagine synthetase vary according to sex. Human Genomics 2024, 18: 67. PMID: 38886847, PMCID: PMC11184737, DOI: 10.1186/s40246-024-00635-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAspartate-Ammonia LigaseCarbon-Nitrogen Ligases with Glutamine as Amide-N-DonorCell ProliferationColorectal NeoplasmsFemaleGene Expression Regulation, NeoplasticHCT116 CellsHeterograftsHumansMaleMiceReceptors, EstrogenReceptors, G-Protein-CoupledSex FactorsXenograft Model Antitumor AssaysConceptsFemale tumor-bearing miceFemale CRC patientsTumor-bearing miceCRC patientsTumor growthInferior survivalAssociated with inferior survivalMetabolic reprogrammingG protein-coupled estrogen receptorTriggering metabolic reprogrammingSustained tumor growthSuppressed tumor growthExpression of asparagine synthetaseCancer cell linesBackgroundSex-related differencesSurvival improvementImpact of sexFemale miceEstrogen receptorCancer growthTranslational relevanceRewiring of metabolic pathwaysCancer burdenMetabolic pathwaysAsparagine synthetase
2022
Systems approach to enhance Lynch syndrome diagnosis through tumour testing
Singh V, Mezzacappa C, Gershkovich P, Di Giovanna J, Ganzak A, Gibson J, Sinard J, Xicola RM, Llor X. Systems approach to enhance Lynch syndrome diagnosis through tumour testing. Journal Of Medical Genetics 2022, 60: 533-539. PMID: 36115663, PMCID: PMC10020126, DOI: 10.1136/jmg-2022-108770.Peer-Reviewed Original ResearchConceptsOriginal cohortColorectal adenocarcinomaLynch syndromeTumor testingGenetic testingPercentage of patientsProportion of patientsLynch syndrome diagnosisCG evaluationCancer genetic testingRace/ethnicityCRC testingCohort studyMMR immunohistochemistryLS diagnosisNew diagnosisMMR lossAcademic centersPatientsSyndrome diagnosisCohortCase identificationMethylation testingReferral differencesReferral mechanisms
2009
Mucosal Schwann Cell “Hamartoma”
Gibson JA, Hornick JL. Mucosal Schwann Cell “Hamartoma”. The American Journal Of Surgical Pathology 2009, 33: 781-787. PMID: 19065103, DOI: 10.1097/pas.0b013e31818dd6ca.Peer-Reviewed Original ResearchMeSH KeywordsActinsAgedAged, 80 and overAntigens, CD34Cell DifferentiationCell ProliferationClaudin-1Colonic PolypsColonoscopyColorectal NeoplasmsDiagnosis, DifferentialFemaleGlial Fibrillary Acidic ProteinHamartomaHumansImmunohistochemistryIncidental FindingsIntestinal MucosaMaleMembrane ProteinsMiddle AgedMucin-1Neurofibromatosis 1Neurofilament ProteinsNeuromaProto-Oncogene Proteins c-kitS100 ProteinsSchwann CellsConceptsLamina propriaHistologic featuresGanglion cellsSchwann cellsColorectal polypsNF1 patientsNeurofilament proteinDense eosinophilic cytoplasmGlial fibrillary acidic proteinSolitary colorectal polypsSimilar histologic featuresBland spindle cellsIndistinct cell bordersType 1 neurofibromatosisEpithelial membrane antigenFibrillary acidic proteinSchwann cell proliferationSmooth muscle actinUniform bland spindle cellsRare axonsMucosal biopsiesPositive axonsImmunohistochemical featuresNeural lesionsIntralesional heterogeneity