Featured Publications
The Zero Suicide Model in Addiction Treatment Settings: Recognizing the Need for Feasibility and Implementation Data
Arakelian M, Barnett B, Weleff J. The Zero Suicide Model in Addiction Treatment Settings: Recognizing the Need for Feasibility and Implementation Data. Psychiatric Services 2023, 75: 378-380. PMID: 37933133, DOI: 10.1176/appi.ps.20230175.Peer-Reviewed Original ResearchConceptsAddiction treatment settingsTreatment settingsZero SuicideSubstance use disordersZero Suicide modelAddiction outcomesUse disorderSuicide modelsAddiction treatmentHealth care settingsAddictionHealth care systemSuicide preventionSuicideImplement best practicesCare settingsCare systemOpen ForumIncreased riskBest practicesHealthDisordersSetsResearchClinicians
2024
Navigating new norms: Addiction specialists' perspectives on opioid use disorder treatments and policy challenges in the fentanyl era
Weleff J, Christian N, Wang J, Singh M, De Aquino J, Saxon A, Vassallo G. Navigating new norms: Addiction specialists' perspectives on opioid use disorder treatments and policy challenges in the fentanyl era. American Journal On Addictions 2024 PMID: 39364597, DOI: 10.1111/ajad.13653.Peer-Reviewed Original ResearchSlow-release oral morphineOpioid use disorderBarriers to OUD treatmentAddiction specialistsOpioid use disorder managementUse disorderOUD treatmentThird-line monotherapyFisher's exact testOpioid use disorder treatmentOff-label prescribingOral morphineAgonist opioidsOpioid agonistsOpioid-related overdoseTherapeutic optionsWithdrawal symptomsNovel therapiesExact testOpioidMOUD prescribingSynthetic opioidsClinical practiceClinical approachCompare respondent characteristicsWernicke’s encephalopathy treated with high dose intravenous thiamine: a case report
Alamir M, Cantu-Weinstein A, Branning R, Weleff J, Anand A. Wernicke’s encephalopathy treated with high dose intravenous thiamine: a case report. Journal Of Addictive Diseases 2024, ahead-of-print: 1-6. PMID: 38946394, DOI: 10.1080/10550887.2024.2365002.Peer-Reviewed Original ResearchAlcohol use disorderWernicke's encephalopathyIV thiamineSymptoms of Wernicke's encephalopathySevere alcohol use disorderFirst-line treatmentLow-risk treatmentTreat neurological symptomsUse disorderHigh-doseCognitive dysfunctionCase reportStandard treatmentNeurological symptomsTreatment guidelinesOptimal doseHigh dosesThiamine deficiencyMental statusDoseChronic malnourishmentTreatmentSymptomsWernickeOphthalmoplegiaPsychotherapeutic Interventions in Clinical Trials of Psychedelics for the Treatment of Alcohol Use Disorder
Mohammad Aghaei A, Weleff J, Martins B, Ing K, Fontenele R, Barnett B, Anand A, Bassir Nia A. Psychotherapeutic Interventions in Clinical Trials of Psychedelics for the Treatment of Alcohol Use Disorder. Current Addiction Reports 2024, 11: 685-712. DOI: 10.1007/s40429-024-00574-y.Peer-Reviewed Original ResearchTreatment of AUDUse disorderTreatment of alcohol use disordersModalities of psychotherapyAlcohol use disorderPsychedelic treatmentPsychotherapeutic interventionsTreat AUDPsychedelic compoundsPsychedelic trialsPsychotherapySmall numbers of participantsPsychedelicsMagnitude of improvementMethodological shortcomingsAUDNumbers of participantsClinical trialsDisordersReviewed trialsShort follow-up periodFollow-up periodTherapy methodsEmpirical evidenceNo significant differenceAssessing pain in persons with opioid use disorder: Approaches, techniques and special considerations
Nunes J, Costa G, Weleff J, Rogan M, Compton P, De Aquino J. Assessing pain in persons with opioid use disorder: Approaches, techniques and special considerations. British Journal Of Clinical Pharmacology 2024 PMID: 38556851, DOI: 10.1111/bcp.16055.Peer-Reviewed Original ResearchOpioid use disorderAssess painPain assessmentPain experienceConcomitant chronic painChronic opioid therapyQuantitative sensory testingVisual analogue scalePain assessment methodsPain assessment toolsComplex psychosocial backgroundImprove pain assessmentOpioid therapyOpioid usePain responseChronic painAnalogue scaleTraditional self-report methodsPainRisk factorsUse disorderOpioidNarrative reviewSelf-report methodsMultidisciplinary teamLSD use in the United States: Examining user demographics and their evolution from 2015–2019
Weleff J, Anand A, Dewey E, Barnett B. LSD use in the United States: Examining user demographics and their evolution from 2015–2019. Journal Of Psychedelic Studies 2024 DOI: 10.1556/2054.2024.00309.Peer-Reviewed Original ResearchLysergic acid diethylamideUnited StatesNational Survey on Drug Use and Health (NSDUHDrug Use and Health (NSDUHLysergic acid diethylamide useArrest historyHallucinogen use disordersLSD useUsers of methamphetaminePublic health problemMultivariate analysisLifetime usersUse disorderPast-year psychological distressAcid diethylamideProportion of respondentsPast-year suicide attemptStudy periodEpidemiological investigationsSocietal acceptanceSuicide attemptsLSD usersApplications of psychedelicsTherapeutic applicationsAssociated with unemployment
2023
Prescribing of Z-Drugs With and Without Opioid Coprescribing to Primary Care Patients in a Large Health Care System From 2019-2020.
Anand A, Weleff J, Thompson N, Barnett B. Prescribing of Z-Drugs With and Without Opioid Coprescribing to Primary Care Patients in a Large Health Care System From 2019-2020. The Journal Of Clinical Psychiatry 2023, 84 PMID: 37707315, DOI: 10.4088/jcp.22m14753.Peer-Reviewed Original ResearchConceptsZ-drug prescribingDiagnosis of opioid use disorderZ-drug prescriptionsOpioid use disorderZ-drugsHealth care systemPrimary care clinicsWhite raceUse disorderCare systemAssociated with increasing ageCare clinicsOlder ageStudy periodDiagnosis of bipolar disorderCross-sectional studyPrimary care patientsLarger health care systemAdult patientsPatient populationOpioidGeneralized anxiety disorderPatientsBipolar disorderPost-lockdownPhencyclidine Positivity on Urine Drug Screening in Patients Treated for Alcohol Withdrawal on a Dual-diagnosis Medically Assisted Withdrawal Unit
Wang P, Dore S, Weleff J, Butler R, Barnett B. Phencyclidine Positivity on Urine Drug Screening in Patients Treated for Alcohol Withdrawal on a Dual-diagnosis Medically Assisted Withdrawal Unit. Journal Of Addiction Medicine 2023, 17: 695-701. PMID: 37934534, DOI: 10.1097/adm.0000000000001217.Peer-Reviewed Original ResearchConceptsAlcohol withdrawalLength of stayPCP-positiveDual diagnosisMultivariate logistic regressionAlcohol use disorderRisk of readmissionToxicological screeningLogistic regressionRetrospective study of patientsSurvival analysisUrine drug screensUrine toxicology screenWithdrawing unitUse disorderAdmission toxicology screeningStudy of patientsCocaine positivityStatistically significant associationPhencyclidineMultivariate linear regression modelPCPRetrospective studyUnivariate testsCocaineCognitive, imaging, and psychiatric changes associated with chronic toluene use: case report and literature review
Jupina M, Weleff J, Harp J, Anand A. Cognitive, imaging, and psychiatric changes associated with chronic toluene use: case report and literature review. Journal Of Addictive Diseases 2023, 42: 556-566. PMID: 37503800, DOI: 10.1080/10550887.2023.2229735.Peer-Reviewed Original ResearchInhalant use disorderUse disorderToluene misuseEvidence-based treatmentsFlat affectVisuospatial functionNeurocognitive deficitsComplex cognitionPsychiatric consequencesPsychiatric deficitsPsychiatric effectsWhite matter changesEffects of tolueneMisuse inhalantsImpact adolescentsDeficitsMatter changesDisordersCognitionInhaler misuseLoss of gray-white matter differentiationDiffuse white matter changesGray-white matter differentiationMisuseCorpus callosum thinning
2022
Black Pepper (Piper nigrum) for Tobacco Withdrawal: A Case Report
Weleff J, Dore S, Anand A, Barnett B. Black Pepper (Piper nigrum) for Tobacco Withdrawal: A Case Report. Case Reports In Psychiatry 2022, 2022: 5908769. PMID: 36530582, PMCID: PMC9757938, DOI: 10.1155/2022/5908769.Peer-Reviewed Original ResearchNicotine withdrawalTobacco withdrawalWithdrawal-associated anxietyTobacco use disorderTreating nicotine withdrawalNicotine cravingTobacco cigarettesUse disorderSensorimotor experienceEffective novel treatmentCravingMotor urgeSignificant public health concernSmall clinical trialsCorrectional settingsNonresearch settingsWithdrawalCase reportClinical trialsPublic health concernNovel treatmentCorrectional facilitiesPatient reportsTobacco cessationTobacco useManagement of Phenibut Use Disorder and Withdrawal in a Geriatric Patient
Wainblat E, Weleff J, Anand A. Management of Phenibut Use Disorder and Withdrawal in a Geriatric Patient. American Journal Of Geriatric Psychiatry 2022, 31: 67-74. PMID: 36266201, DOI: 10.1016/j.jagp.2022.09.008.Peer-Reviewed Original ResearchConceptsUse disorderAlcohol use disorderAnxiolytic use disorderWorsen affective disordersAffective disordersPhysiological dependenceMisuse substancesNootropic propertiesWithdrawal managementAlleviate anxietyFood and Drug AdministrationDisordersPhenibutWithdrawalAddictionClinical effectsGeriatric patientsDrug AdministrationGeriatric populationDrug profileAlcoholAnxietyBenzodiazepinesAnxiolysisInsomniaPsychedelics in the Treatment of Substance Use Disorders
Barnett B, Weleff J. Psychedelics in the Treatment of Substance Use Disorders. Psychiatric Annals 2022, 52: 365-370. DOI: 10.3928/00485713-20220804-01.Peer-Reviewed Original ResearchSubstance use disordersPsychedelic experienceTreatment of substance use disordersLysergic acid diethylamideSubjective effectsUse disorderAcid diethylamidePlacebo-controlled trialPsychedelicsBehavioral changesTherapeutic potentialClinician concernsLife narrativesDisordersFacilitation programTreatment paradigmTherapeutic efficacyClinical trialsTreatment potentialObservational studyPsilocybinDiethylamideTrialsSubstancesOpioid
2019
322 Resource Utilization for Patients Presenting to Emergency Department With Mental and Substance Use Disorders: National Hospital Ambulatory Medical Care Survey Analysis
Lopez R, Schold J, Weleff J, Phelan M. 322 Resource Utilization for Patients Presenting to Emergency Department With Mental and Substance Use Disorders: National Hospital Ambulatory Medical Care Survey Analysis. Annals Of Emergency Medicine 2019, 74: s126. DOI: 10.1016/j.annemergmed.2019.08.281.Peer-Reviewed Original Research