2022
Association of Renin-Angiotensin-Aldosterone System Inhibitor Usage Patterns with Midterm Amputation-Free Survival after Lower Extremity Bypass for Peripheral Arterial Disease
Naazie I, Arhuidese I, Abdelgawwad M, Unkart J, Conte M, Malas M. Association of Renin-Angiotensin-Aldosterone System Inhibitor Usage Patterns with Midterm Amputation-Free Survival after Lower Extremity Bypass for Peripheral Arterial Disease. Annals Of Vascular Surgery 2022, 88: 79-89. PMID: 36028182, DOI: 10.1016/j.avsg.2022.07.022.Peer-Reviewed Original ResearchConceptsRenin-angiotensin-aldosterone system inhibitor useRenin-angiotensin-aldosterone system inhibitorsLower extremity bypassAmputation-free survivalPeripheral arterial diseaseArtery diseaseAssociated with improved 30-day mortalityAssociated with improved survivalAssociated with 2.8-foldPeripheral arterial disease patientsLEB outcomesArtery disease patientsLower-extremity bypassSurvival benefitSystem inhibitorsPostoperative periodRAAS inhibitionStudy cohortCox regressionPrimary outcomePotential confoundersIncreased oddsDisease patientsPatientsMortality
2021
Contemporary outcomes of concomitant suprainguinal bypass with infrainguinal revascularization procedures in patients with chronic limb-threatening ischemia
Naazie I, Zarrintan S, Arhuidese I, Al-Nouri O, Abou-Zamzam A, Malas M. Contemporary outcomes of concomitant suprainguinal bypass with infrainguinal revascularization procedures in patients with chronic limb-threatening ischemia. Journal Of Vascular Surgery 2021, 75: 989-997.e1. PMID: 34606957, DOI: 10.1016/j.jvs.2021.08.105.Peer-Reviewed Original ResearchConceptsChronic limb-threatening ischemiaRisk of amputationSuprainguinal bypassRest painAmputation-free survivalIncreased riskLimb-threatening ischemiaInfrainguinal revascularizationTissue lossMajor amputationInfrainguinal bypassRevascularization proceduresIncreased risk of amputationPerioperative myocardial infarction rateAssociated with decreased riskConcomitant infrainguinal bypassOutcomes of patientsLog-rank testPerioperative myocardial infarctionKaplan-Meier survivalTreatment of patientsVascular Quality InitiativeMyocardial infarction rateInfrainguinal revascularization proceduresIncreased oddsImpact of impaired ambulatory capacity on the outcomes of peripheral vascular interventions among patients with chronic limb-threating ischemia
Naazie I, Arhuidese I, Zil-E-Ali A, Siracuse J, Malas M. Impact of impaired ambulatory capacity on the outcomes of peripheral vascular interventions among patients with chronic limb-threating ischemia. Journal Of Vascular Surgery 2021, 74: 489-498.e1. PMID: 33548441, DOI: 10.1016/j.jvs.2020.12.088.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAmputation, SurgicalChronic DiseaseDependent AmbulationEndovascular ProceduresFemaleFunctional StatusHospital MortalityHumansIschemiaLimb SalvageMaleMiddle AgedMobility LimitationPeripheral Arterial DiseaseProgression-Free SurvivalRegistriesRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsConceptsChronic limb-threatening ischemiaAmbulatory with assistanceAmputation-free survivalWheelchair-bound patientsAmbulatory capacityNonambulatory patientsBedridden patientsAmbulatory patientsPoor functional statusPeripheral endovascular interventionsAmbulatory impairmentIn-hospital deathLimb-threatening ischemiaFunctional statusPostoperative complicationsSecondary outcomesLogistic regressionPeripheral vascular interventionsPrimary outcomeQuality InitiativeEndovascular interventionStudy outcomesAmputationOdds of postoperative complicationsWheelchair-bound
2019
Outcomes of Infrainguinal Lower Extremity Bypass Are Superior in Kidney Transplant Recipients Than Patients with Dialysis
Nejim B, Hicks C, Arhuidese I, Locham S, Dakour-Aridi H, Malas M. Outcomes of Infrainguinal Lower Extremity Bypass Are Superior in Kidney Transplant Recipients Than Patients with Dialysis. Annals Of Vascular Surgery 2019, 63: 209-217. PMID: 31349053, DOI: 10.1016/j.avsg.2019.04.026.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmputation, SurgicalBlood Vessel Prosthesis ImplantationDatabases, FactualFemaleHumansKidney Failure, ChronicKidney TransplantationLimb SalvageLower ExtremityMaleMiddle AgedPeripheral Arterial DiseaseProgression-Free SurvivalRenal DialysisRetrospective StudiesRisk FactorsSaphenous VeinTime FactorsVascular PatencyConceptsLower extremity bypassEnd-stage renal diseaseKT recipientsPrimary patencyDialysis therapyAmputation-free survivalKidney transplantationVascular Quality Initiative databaseRisk-adjusted hazardsKidney transplant recipientsPositive effects of KTRisk of mortalityEffects of KTRisk of amputationLower-extremity bypassSurgical outcomesTransplant recipientsBaseline characteristicsBypass proceduresDialysis patientsRenal diseaseComparative efficacyKT groupDT groupPatients
2018
Aggressive infrainguinal revascularization in renal transplant patients is justifiable
Craig-Schapiro R, Nejim B, Arhuidese I, Malas M. Aggressive infrainguinal revascularization in renal transplant patients is justifiable. American Journal Of Transplantation 2018, 18: 1718-1725. PMID: 29288558, DOI: 10.1111/ajt.14636.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmputation, SurgicalFemaleFollow-Up StudiesHumansKidney Failure, ChronicKidney TransplantationLimb SalvageLower ExtremityMaleMiddle AgedPatient SelectionPostoperative ComplicationsPrognosisReoperationRetrospective StudiesRisk AssessmentRisk FactorsSurvival RateTime FactorsVascular GraftingVascular PatencyConceptsCritical limb ischemiaRenal transplant patientsTransplant patientsNontransplant patientsLimb ischemiaPrimary patencyInfrainguinal revascularizationRisk factorsMultivariate Cox regression analysisVascular Quality Initiative databaseEnd-stage renal diseaseDistal bypassCox regression analysisOutcomes of lower extremity revascularizationPrimary patency lossLower extremity revascularizationAmputation-free survivalLimb salvage outcomesAssociated with limb lossOverall survivalProsthetic conduitVein conduitPatency lossRenal diseaseInfrainguinal bypass
2014
Design of the Revascularization With Open Bypass vs Angioplasty and Stenting of the Lower Extremity Trial (ROBUST): A Randomized Clinical Trial
Malas M, Qazi U, Glebova N, Arhuidese I, Reifsnyder T, Black J, Perler B, Freischlag J. Design of the Revascularization With Open Bypass vs Angioplasty and Stenting of the Lower Extremity Trial (ROBUST): A Randomized Clinical Trial. JAMA Surgery 2014, 149: 1289-1295. PMID: 25353642, DOI: 10.1001/jamasurg.2014.369.Peer-Reviewed Original ResearchConceptsReduce health care costsRandomized clinical trialsOpen bypassPercutaneous transluminal angioplastyCritical limb ischemiaHospital admission costsQuality-of-life questionnaireHealth care costsAnkle brachial indexQuality of lifeImprovement of quality of lifeEXTREME trialClinical trialsTransluminal angioplastyLimb ischemiaAmputation-free survivalTransAtlantic Inter-Society ConsensusCare costsRobust trialsFemoropopliteal bypassTASC II BSecondary aimAdmission costsBrachial indexSuperficial femoral artery lesions