2020
Dysregulation of Magnesium Transport Protects Bacillus subtilis against Manganese and Cobalt Intoxication
Pi H, Wendel B, Helmann J. Dysregulation of Magnesium Transport Protects Bacillus subtilis against Manganese and Cobalt Intoxication. Journal Of Bacteriology 2020, 202: 10.1128/jb.00711-19. PMID: 31964700, PMCID: PMC7167470, DOI: 10.1128/jb.00711-19.Peer-Reviewed Original Research
2018
Genome-Wide Characterization of the Fur Regulatory Network Reveals a Link between Catechol Degradation and Bacillibactin Metabolism in Bacillus subtilis
Pi H, Helmann J. Genome-Wide Characterization of the Fur Regulatory Network Reveals a Link between Catechol Degradation and Bacillibactin Metabolism in Bacillus subtilis. MBio 2018, 9: 10.1128/mbio.01451-18. PMID: 30377275, PMCID: PMC6212828, DOI: 10.1128/mbio.01451-18.Peer-Reviewed Original ResearchConceptsRegulatory networksCatechol degradationPutative DNA binding sitesGenome-wide identificationGenome-wide characterizationFerric uptake regulatorIron-dependent transcriptional repressorCellular iron requirementsDNA binding sitesIron-sufficient conditionsIron-limiting conditionsHigh-affinity iron chelatorsEnvironmental aromatic compoundsSiderophore bacillibactinFur regulonGenomic viewApo-FurRepressor functionTranscriptional repressorRegulated genesChromatin immunoprecipitationPositive regulatorIron acquisitionNegative regulationGenetic analysis
2017
Sequential induction of Fur-regulated genes in response to iron limitation in Bacillus subtilis
Pi H, Helmann J. Sequential induction of Fur-regulated genes in response to iron limitation in Bacillus subtilis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 12785-12790. PMID: 29133393, PMCID: PMC5715773, DOI: 10.1073/pnas.1713008114.Peer-Reviewed Original ResearchConceptsFerric uptake regulatorHigh-affinity FeIron availabilityPerR regulonFur regulonSiderophore bacillibactinGenetic toolsChIP experimentsIron limitationCell transitionBacillus subtilisHigh-affinity bindingIron homeostasisBacterial cellsIntracellular ironSequential inductionRegulonBacillibactinEnzyme accessVivo occupancyGenesFurIron poolIron sufficiencyEfflux transporters
2016
The Listeria monocytogenes Fur‐regulated virulence protein FrvA is an Fe(II) efflux P1B4‐type ATPase
Pi H, Patel S, Argüello J, Helmann J. The Listeria monocytogenes Fur‐regulated virulence protein FrvA is an Fe(II) efflux P1B4‐type ATPase. Molecular Microbiology 2016, 100: 1066-1079. PMID: 26946370, PMCID: PMC4914386, DOI: 10.1111/mmi.13368.Peer-Reviewed Original Research