2021
Maternal Piwi regulates primordial germ cell development to ensure the fertility of female progeny in Drosophila
Gonzalez LE, Tang X, Lin H. Maternal Piwi regulates primordial germ cell development to ensure the fertility of female progeny in Drosophila. Genetics 2021, 219: iyab091. PMID: 34142134, PMCID: PMC8757300, DOI: 10.1093/genetics/iyab091.Peer-Reviewed Original ResearchConceptsPIWI-interacting RNAsGermline developmentPiwi knockdownPIWI proteinsEarly embryosPiwi/piRNA complexesPIWI/piRNA pathwayFemale progenyPrimordial germ cell developmentGermline sex determinationLoss of PiwiGermline stem cellsDrosophila early embryosGerm cell developmentGerm cell proliferationGonad coalescencePiRNA complexesPiRNA pathwayPiRNA poolTransposon suppressionZygotic genesEmbryonic germlineEmbryonic functionEarly embryogenesisPiwi
2002
Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas
Qiao D, Zeeman AM, Deng W, Looijenga LH, Lin H. Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas. Oncogene 2002, 21: 3988-3999. PMID: 12037681, DOI: 10.1038/sj.onc.1205505.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceArgonaute ProteinsBlotting, NorthernChildChromosome MappingChromosomes, Human, Pair 12Cloning, MolecularDNA PrimersDNA, ComplementaryDrosophila ProteinsFormazansGene LibraryHumansImmunoenzyme TechniquesIn Situ HybridizationMaleMolecular Sequence DataPolymerase Chain ReactionProteinsRNA, MessengerRNA-Induced Silencing ComplexSeminomaSequence Homology, Amino AcidTeratomaTesticular NeoplasmsTetrazolium SaltsConceptsGene familyPiwi gene familyHuman membersGerm cellsMolecular characterizationPiwi family genesPIWI family proteinsEnhanced expressionEmbryonic germ cellsGerm cell phenotypeGerm cell characteristicsGerm cell proliferationStage-dependent patternDiverse organismsDrosophila melanogasterC. elegansGermline cellsGenomic regionsFamily genesFamily proteinsSignificant homologySame precursor cellRNA interferenceChromosomal regionsKb mRNA