2024
12241 Association Between Brain Glucose And Circulating Glucagon Levels In Response To Acute Hyperglycemia
Matson B, Gunawan F, Coppoli A, Jiang L, Rangel E, De Aguiar R, Rothman D, Mason G, Hwang J. 12241 Association Between Brain Glucose And Circulating Glucagon Levels In Response To Acute Hyperglycemia. Journal Of The Endocrine Society 2024, 8: bvae163.674. PMCID: PMC11454728, DOI: 10.1210/jendso/bvae163.674.Peer-Reviewed Original ResearchCentral nervous systemBrain glucose levelsPlasma glucagon levelsHyperglycemic clampType 2 diabetesGlucagon levelsGlucagon secretionGlucose levelsResponse to hyperglycemiaAcute hyperglycemiaOral glucose tolerance testBrain glucose metabolismResponse to central nervous systemPathophysiology of type 2 diabetesResponse to hypoglycemiaBrain glucoseIndices of insulin sensitivityEffect of obesityRegulation of glucagon secretionGlucose tolerance testConsequences of obesityModulating glucagon secretionOvert metabolic abnormalitiesBrain glucose uptakeCirculating glucagon levels1583-P: Measuring Mitochondrial Metabolism In Vivo with [1,2-13C2]-L-Glutamine Mass Isotopomers
SIEBEL S, CARDONE R, MASON G, KIBBEY R. 1583-P: Measuring Mitochondrial Metabolism In Vivo with [1,2-13C2]-L-Glutamine Mass Isotopomers. Diabetes 2024, 73 DOI: 10.2337/db24-1583-p.Peer-Reviewed Original ResearchIndirect 1H–[13C] MRS of the human brain at 7 T using a 13C‐birdcage coil and eight transmit–receive 1H‐dipole antennas with a 32‐channel 1H‐receive array
Jacobs S, Prompers J, van der Kemp W, van der Velden T, Gosselink M, Meliadò E, Hoogduin H, Mason G, de Graaf R, Miller C, Bredael G, van der Kolk A, Alborahal C, Klomp D, Wiegers E. Indirect 1H–[13C] MRS of the human brain at 7 T using a 13C‐birdcage coil and eight transmit–receive 1H‐dipole antennas with a 32‐channel 1H‐receive array. NMR In Biomedicine 2024, 37: e5195. PMID: 38845018, DOI: 10.1002/nbm.5195.Peer-Reviewed Original ResearchStimulated echo acquisition modeSignal-to-noise ratioSlice-selective excitationAdiabatic selective refocusingUltra-high fieldIncreased spectral dispersionEcho acquisition modeSpectral dispersionVoxel positionSemi-localPhantomAcquisition modeElectromagnetic simulationsHuman brainSAR limitsExcitationBi-frontalSLASERHealthy volunteersSpectraDeficits in brain glucose transport among younger adults with obesity
Gunawan F, Matson B, Coppoli A, Jiang L, Ding Y, Perry R, Sanchez‐Rangel E, DeAguiar R, Behar K, Rothman D, Mason G, Hwang J. Deficits in brain glucose transport among younger adults with obesity. Obesity 2024, 32: 1329-1338. PMID: 38764181, DOI: 10.1002/oby.24034.Peer-Reviewed Original ResearchBrain glucose transportLean participantsMarkers of insulin resistanceMagnetic resonance spectroscopy scansEffect of obesityAssociated with alterationsLong-term brain functionCerebral glucose metabolic rateGlucose transportGlucose metabolic rateCardiometabolic comorbiditiesBrain energy utilizationPeripheral markersHyperglycemic clampInsulin resistanceObesityBrain glucose uptakeHuman findingsEating behaviorsYounger ageYoung healthy participantsNeurocognitive functionGlucose transport capacityBrain functionNonesterified fatty acids366. The Effect of Early Life Trauma on Prefrontal Synaptic Strength in Major Depressive and Posttraumatic Stress Disorders
Del Motte M, Tamman A, Jiang L, Averill C, Mason G, Averill L, Abdallah C. 366. The Effect of Early Life Trauma on Prefrontal Synaptic Strength in Major Depressive and Posttraumatic Stress Disorders. Biological Psychiatry 2024, 95: s249. DOI: 10.1016/j.biopsych.2024.02.865.Peer-Reviewed Original Research
2023
Cortical GABA Levels Are Reduced in Post-Acute COVID-19 Syndrome
Marinkovic K, White D, Myers A, Parker K, Arienzo D, Mason G. Cortical GABA Levels Are Reduced in Post-Acute COVID-19 Syndrome. Brain Sciences 2023, 13: 1666. PMID: 38137114, PMCID: PMC10741691, DOI: 10.3390/brainsci13121666.Peer-Reviewed Original ResearchAcute COVID-19 illnessCOVID-19 illnessGABA levelsN-acetylaspartatePost-acute COVID-19 syndromeCortical GABA levelsPersistent cognitive dysfunctionPost-acute sequelaeCOVID-19 syndromeExcitation/inhibition imbalancePoor sleep qualityProton magnetic resonance spectroscopyDepression/anxietyQuality of lifePersistent neuroinflammationBrain fogCortical hyperexcitabilityLong COVIDAlcohol intakeCognitive dysfunctionNeuronal integrityNeurocognitive dysfunctionNeurochemical aspectsSleep qualityOccipital cortexBiological embedding of early trauma: the role of higher prefrontal synaptic strength
Tamman A, Jiang L, Averill C, Mason G, Averill L, Abdallah C. Biological embedding of early trauma: the role of higher prefrontal synaptic strength. European Journal Of Psychotraumatology 2023, 14: 2246338. PMID: 37642398, PMCID: PMC10467533, DOI: 10.1080/20008066.2023.2246338.Peer-Reviewed Original ResearchConceptsEarly traumaApproach/avoidance tendenciesReward responsivityAvoidance tendenciesBehavioral inhibitionSynaptic strengthPutative measurePhysical healthBiological embeddingHealthy controlsLarge human samplePTSDSynaptic processesGlutamatergic synaptic strengthPsychiatric disordersHigher EPCHuman samplesStudy findingsGlutamatergic excitotoxicityPharmacological treatmentDirect measureMeasuresTraumaEmotionsSynaptic plasticityReproducibility of 13C labeling of glutamate and glutamine in human brain using selPOCE MRS at 7T upon [U-13C]-labeled glucose infusion
Ahmadian N, Jacobs S, Gosselink M, van der Kemp W, Hoogduin H, Coppoli A, Mason G, de Graaf R, Norouzizadeh H, Mahon C, van Marle S, van Eijsden P, Cerneus D, Miller C, De Lepeleire I, Basile A, Klomp D, Prompers J, Wiegers E. Reproducibility of 13C labeling of glutamate and glutamine in human brain using selPOCE MRS at 7T upon [U-13C]-labeled glucose infusion. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/5332.Peer-Reviewed Original ResearchMeasurement of neuro‐energetics and neurotransmission in the rat olfactory bulb using 1H and 1H–[13C] NMR spectroscopy
Chowdhury G, Behar K, Mason G, Rothman D, de Graaf R. Measurement of neuro‐energetics and neurotransmission in the rat olfactory bulb using 1H and 1H–[13C] NMR spectroscopy. NMR In Biomedicine 2023, 37: e4957. PMID: 37088548, PMCID: PMC10590826, DOI: 10.1002/nbm.4957.Peer-Reviewed Original ResearchNuclear magnetic resonance imaging and spectroscopy: basic principles and recent findings in neuropsychiatric disorders
Mason GF, Krystal JH, Sanacora G. Nuclear magnetic resonance imaging and spectroscopy: basic principles and recent findings in neuropsychiatric disorders. In Comprehensive Textbook of Psychiatry, Wolters Kluwer (Sadock BJ, Sadock VA, Ruiz P, eds.) (in press)Chapters
2022
Q-Flux: A method to assess hepatic mitochondrial succinate dehydrogenase, methylmalonyl-CoA mutase, and glutaminase fluxes in vivo
Hubbard B, LaMoia T, Goedeke L, Gaspar R, Galsgaard K, Kahn M, Mason G, Shulman G. Q-Flux: A method to assess hepatic mitochondrial succinate dehydrogenase, methylmalonyl-CoA mutase, and glutaminase fluxes in vivo. Cell Metabolism 2022, 35: 212-226.e4. PMID: 36516861, PMCID: PMC9887731, DOI: 10.1016/j.cmet.2022.11.011.Peer-Reviewed Original ResearchHuman brain POCE MRS at 7T using a 13C birdcage coil and 8 transmit-receive 1H antennas with a 32-channel 1H receive array
Jacobs S, Prompers J, van der Kemp W, van der Velden T, Gosselink M, Meliadò E, Hoogduin H, Mason G, de Graaf R, van der Kolk A, Alborahal C, Klomp D, Wiegers E. Human brain POCE MRS at 7T using a 13C birdcage coil and 8 transmit-receive 1H antennas with a 32-channel 1H receive array. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2022 DOI: 10.58530/2022/1536.Peer-Reviewed Original Research
2021
Methods | 13C MRS Measurements of in Vivo Rates of the Glutamate/Glutamine and GABA/Glutamine Neurotransmitter Cycles
Rothman D, De Feyter H, Mason G, de Graaf R, Hyder F, Behar K. Methods | 13C MRS Measurements of in Vivo Rates of the Glutamate/Glutamine and GABA/Glutamine Neurotransmitter Cycles. 2021, 688-700. DOI: 10.1016/b978-0-12-819460-7.00341-8.Chapters
2020
1772-P: Reversibility of Altered Brain Glucose Kinetics in T2DM
RANGEL E, GUNAWAN F, JIANG L, SAVOYE M, DAI F, ROTHMAN D, MASON G, HWANG J. 1772-P: Reversibility of Altered Brain Glucose Kinetics in T2DM. Diabetes 2020, 69 DOI: 10.2337/db20-1772-p.Peer-Reviewed Original ResearchBrain glucose levelsPoor glycemic controlGlycemic controlGlucose levelsCentral nervous system complicationsNervous system complicationsBrain glucose transportPlasma glucose levelsContinuous glucose monitoringUncontrolled T2DMT2DM subjectsSystem complicationsBMI changeHyperglycemic clampHealthy controlsDiabetes regimenPost interventionHierarchical linear regression modelsGlucose time coursesMagnetic resonance spectroscopyHbA1cGlucose kineticsGlucose monitoringNational InstituteT2DMImpaired neuronal and astroglial metabolic activity in chronic unpredictable mild stress model of depression: Reversal of behavioral and metabolic deficit with lanicemine
Mishra PK, Adusumilli M, Deolal P, Mason GF, Kumar A, Patel AB. Impaired neuronal and astroglial metabolic activity in chronic unpredictable mild stress model of depression: Reversal of behavioral and metabolic deficit with lanicemine. Neurochemistry International 2020, 137: 104750. PMID: 32360130, DOI: 10.1016/j.neuint.2020.104750.Peer-Reviewed Original ResearchConceptsChronic unpredictable mild stressCUMS micePrefrontal cortexChronic unpredictable mild stress (CUMS) modelNeurotransmitter cyclingThree-compartment metabolic modelUnpredictable mild stressCause of disabilityNMDA receptor antagonistPotential therapeutic roleMajor depressive disorderAstrocytic TCA cycleNeural metabolic activityMetabolic activityGABAergic neuronsInhibitory neurotransmissionReceptor antagonistSwim testSucrose preferenceC57BL6 miceDepressive disorderTherapeutic roleChronic depressionGlutamatergic pathwaysMetabolic deficitsA novel biomarker of neuronal glutamate metabolism in non-human primate using localized 1H MRS: Development and effects of BNC375, an α7 nicotinic acetylcholine receptor positive allosteric modulator.
Miller CO, Liza T. Gantert LT, Previs SF, Chen Y, Anderson KD, Thomas JM, Sanacora S, Uslaner JM, Rothman DL, Mason GF. Biol Psych: Cogn Neurosci Neuroimag (in press)Peer-Reviewed Original Research
2017
Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging Study
Abdallah CG, Hannestad J, Mason GF, Holmes SE, DellaGioia N, Sanacora G, Jiang L, Matuskey D, Satodiya R, Gasparini F, Lin X, Javitch J, Planeta B, Nabulsi N, Carson RE, Esterlis I. Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging Study. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2017, 2: 449-456. PMID: 28993818, PMCID: PMC5630181, DOI: 10.1016/j.bpsc.2017.03.019.Peer-Reviewed Original ResearchMajor depressive disorderMetabotropic glutamate receptor 5Positron emission tomographyGlutamate receptor 5Healthy controlsGlx levelsMGluR5 availabilityDepressive disorderReceptor 5Glx/Cr levelsAnterior cingulate glutamateGlutamate/CrRole of mGluR5Proton magnetic resonance spectroscopyDistribution volume ratioMultimodal Imaging StudyACC glutamateGlutamatergic systemGlutamate involvementGlutamate levelsPostmortem studiesEmission tomographyImaging studiesMGluR5Cr levelsThe human brain produces fructose from glucose
Hwang JJ, Jiang L, Hamza M, Dai F, Belfort-DeAguiar R, Cline G, Rothman DL, Mason G, Sherwin RS. The human brain produces fructose from glucose. JCI Insight 2017, 2: e90508. PMID: 28239653, PMCID: PMC5313070, DOI: 10.1172/jci.insight.90508.Peer-Reviewed Original ResearchConceptsPolyol pathwayFructose levelsIntracerebral glucoseBlood-brain barrierPathogenesis of obesityType 2 diabetesEffects of fructoseHuman brainRegression model analysisCNS deliveryCNS effectsHyperglycemic clampHealthy subjectsDietary consumptionGlucoseBaselineBrainMixed-effects regression model analysisFeeding behaviorMinutesCN productionObesityDiabetesLevelsPathogenesis
2016
Reproducibility measurement of glutathione, GABA, and glutamate: Towards in vivo neurochemical profiling of multiple sclerosis with MR spectroscopy at 7T
Prinsen H, de Graaf RA, Mason GF, Pelletier D, Juchem C. Reproducibility measurement of glutathione, GABA, and glutamate: Towards in vivo neurochemical profiling of multiple sclerosis with MR spectroscopy at 7T. Journal Of Magnetic Resonance Imaging 2016, 45: 187-198. PMID: 27351712, PMCID: PMC5167659, DOI: 10.1002/jmri.25356.Peer-Reviewed Original Research
2015
Integrated, Step-Wise, Mass-Isotopomeric Flux Analysis of the TCA Cycle
Alves TC, Pongratz RL, Zhao X, Yarborough O, Sereda S, Shirihai O, Cline GW, Mason G, Kibbey RG. Integrated, Step-Wise, Mass-Isotopomeric Flux Analysis of the TCA Cycle. Cell Metabolism 2015, 22: 936-947. PMID: 26411341, PMCID: PMC4635072, DOI: 10.1016/j.cmet.2015.08.021.Peer-Reviewed Original Research