2020
TB and women: a call to action
Daftary A, Furin J, Zelnick J, Venkatesan N, Steingart K, Smelyanskaya M, Seepamore B, Schoeman I, Reid M, Padayatchi N, O Donnell M, Mistry N, McKenna L, Mahbub T, Macdonald H, Loveday M, Law S, LaCourse S, Jaramillo E, Janssen R, Hirsch-Moverman Y, Friedland G, Creswell J, Chorna Y, Chikovore J, Brigden G, Boffa J, Boehme C, Atre S, Amico K, Acquah R, Engel N. TB and women: a call to action. The International Journal Of Tuberculosis And Lung Disease 2020, 24: 1312-1315. PMID: 33317679, DOI: 10.5588/ijtld.20.0414.Peer-Reviewed Original Research
2019
Opportunities for community health workers to contribute to global efforts to end tuberculosis
Sinha P, Shenoi SV, Friedland GH. Opportunities for community health workers to contribute to global efforts to end tuberculosis. Global Public Health 2019, 15: 474-484. PMID: 31516079, PMCID: PMC7028491, DOI: 10.1080/17441692.2019.1663361.Peer-Reviewed Original Research
2016
Cost-Effectiveness of Community-Based TB/HIV Screening and Linkage to Care in Rural South Africa
Gilbert JA, Shenoi SV, Moll AP, Friedland GH, Paltiel AD, Galvani AP. Cost-Effectiveness of Community-Based TB/HIV Screening and Linkage to Care in Rural South Africa. PLOS ONE 2016, 11: e0165614. PMID: 27906986, PMCID: PMC5131994, DOI: 10.1371/journal.pone.0165614.Peer-Reviewed Original ResearchConceptsTB/HIVTB/HIV controlHIV screeningHIV controlRural South AfricaLife yearsMonths of IPTMost life yearsHigh-incidence settingsWidespread prevalenceCost-effectiveness resultsProbabilistic sensitivity analysesHIV transmissionHigh burdenTreatment coverageUnknown patientsHIVHealthcare accessDrug resistanceActive casesMonthsLifetime usePatientsYearsScreening
2015
Successful Tuberculosis Treatment Outcomes among HIV/TB Coinfected Patients Down-Referred from a District Hospital to Primary Health Clinics in Rural South Africa
Jacobson KB, Moll AP, Friedland GH, Shenoi SV. Successful Tuberculosis Treatment Outcomes among HIV/TB Coinfected Patients Down-Referred from a District Hospital to Primary Health Clinics in Rural South Africa. PLOS ONE 2015, 10: e0127024. PMID: 25993636, PMCID: PMC4438008, DOI: 10.1371/journal.pone.0127024.Peer-Reviewed Original ResearchConceptsTB treatment outcomesTB/HIVTreatment outcomesHIV clinicDistrict hospitalRetained patientsTreatment completionTreatment successRural South AfricaSuccessful tuberculosis treatment outcomeMajor public health threatDrug-susceptible TBHospital HIV clinicLinkage of careTB treatment completionTB treatment initiationTB treatment servicesTuberculosis treatment outcomesHIV/TBBaseline disease severityNew TB casesPrimary health clinicsPrimary care levelSpecific clinical criteriaHigher treatment successIntegrating Community-Based Interventions to Reverse the Convergent TB/HIV Epidemics in Rural South Africa
Gilbert JA, Long EF, Brooks RP, Friedland GH, Moll AP, Townsend JP, Galvani AP, Shenoi SV. Integrating Community-Based Interventions to Reverse the Convergent TB/HIV Epidemics in Rural South Africa. PLOS ONE 2015, 10: e0126267. PMID: 25938501, PMCID: PMC4418809, DOI: 10.1371/journal.pone.0126267.Peer-Reviewed Original ResearchConceptsTB/HIVHIV control strategiesMDR-TBXDR-TBHIV deathsHIV casesHIV epidemicRural South AfricaTB/HIV casesTB treatment delayIsoniazid preventive therapyDrug-resistant TBHIV treatment programsTreatment cure ratesHIV case findingHIV control effortsNovel screening programPreventive therapyTB casesTB treatmentTreatment delayHIV transmissionCure rateQuestionnaire's sensitivityScreening program
2014
Intensified specimen collection to improve tuberculosis diagnosis in children from Rural South Africa, an observational study
Thomas TA, Heysell SK, Moodley P, Montreuil R, Ha X, Friedland G, Bamber SA, Moll AP, Gandhi N, Brant WE, Sturm W, Shah S. Intensified specimen collection to improve tuberculosis diagnosis in children from Rural South Africa, an observational study. BMC Infectious Diseases 2014, 14: 11. PMID: 24400822, PMCID: PMC3890632, DOI: 10.1186/1471-2334-14-11.Peer-Reviewed Original ResearchConceptsDrug susceptibility testingGastric aspiratesTB suspectsObservational studySpecimen collectionDrug-susceptible TBNew TB suspectsPediatric TB suspectsTB treatment historyXDR-TB casesMultiple specimen typesYears of ageSame-day methodTB settingsInduced sputumPersistent symptomsSputum inductionTB treatmentHIV statusNegative childrenTB diagnosisUrine cultureMean ageInpatient settingDiagnostic yield
2013
Transmission of Tuberculosis in Resource-Limited Settings
Kompala T, Shenoi SV, Friedland G. Transmission of Tuberculosis in Resource-Limited Settings. Current HIV/AIDS Reports 2013, 10: 264-272. PMID: 23824469, PMCID: PMC3809054, DOI: 10.1007/s11904-013-0164-x.Peer-Reviewed Original ResearchConceptsDrug-resistant TBTB transmissionCommunity settingsInfection controlHigh HIV prevalenceInfection control practicesTransmission of tuberculosisHousehold contact tracingResource limited settingsHealth care facilitiesResource-constrained settingsHIV prevalenceTB epidemicContinued transmissionCommon siteUnrecognized transmissionContact tracingCommunity sitesControl practicesHold promiseRecent studiesTransmission reductionIntensive caseSettingTBNatural ventilation reduces high TB transmission risk in traditional homes in rural KwaZulu-Natal, South Africa
Lygizos M, Shenoi SV, Brooks RP, Bhushan A, Brust J, Zelterman D, Deng Y, Northrup V, Moll AP, Friedland GH. Natural ventilation reduces high TB transmission risk in traditional homes in rural KwaZulu-Natal, South Africa. BMC Infectious Diseases 2013, 13: 300. PMID: 23815441, PMCID: PMC3716713, DOI: 10.1186/1471-2334-13-300.Peer-Reviewed Original ResearchConceptsTB transmission riskInfectious TB patientsTransmission riskTB patientsRural South AfricaDrug-resistant TBTB control effortsHealth care facilitiesPaucity of dataHousehold settingsRural KwaZulu-NatalPrevalent TBResistant TBTB transmissionCare facilitiesMultivariate analysisHIV areasVentilationAChSignificant decreaseWells-Riley equationPatientsRiskLow ventilationHour period
2012
The immune reconstitution inflammatory syndrome after antiretroviral therapy initiation in patients with tuberculosis: findings from the SAPiT trial.
Naidoo K, Yende-Zuma N, Padayatchi N, Naidoo K, Jithoo N, Nair G, Bamber S, Gengiah S, El-Sadr WM, Friedland G, Abdool Karim S. The immune reconstitution inflammatory syndrome after antiretroviral therapy initiation in patients with tuberculosis: findings from the SAPiT trial. Annals Of Internal Medicine 2012, 157: 313-24. PMID: 22944873, PMCID: PMC3534856, DOI: 10.7326/0003-4819-157-5-201209040-00004.Peer-Reviewed Original ResearchMeSH KeywordsAdultAIDS-Related Opportunistic InfectionsAntibiotics, AntitubercularAnti-Retroviral AgentsCD4 Lymphocyte CountFemaleHIV InfectionsHumansImmune Reconstitution Inflammatory SyndromeImmunocompromised HostIncidenceKaplan-Meier EstimateMaleProspective StudiesRifampinRisk FactorsSeverity of Illness IndexTuberculosisConceptsImmune reconstitution inflammatory syndromeSequential treatment groupIncidence of IRISReconstitution inflammatory syndromeAntiretroviral therapy initiationART initiationTreatment groupsIRIS incidenceSAPiT trialInflammatory syndromeTherapy initiationTreatment initiationTuberculosis treatmentOpen-label clinical trialCells/LCo-infected patientsEarly ART initiationInitiation of ARTTuberculosis treatment initiationSmear-negative tuberculosisHigher hospitalization ratesWeeks of completionBaseline CD4Antituberculosis treatmentNonambulatory patientsTuberculosis infection control in a high drug-resistance setting in rural South Africa: Information, motivation, and behavioral skills
Kanjee Z, Amico KR, Li F, Mbolekwa K, Moll AP, Friedland GH. Tuberculosis infection control in a high drug-resistance setting in rural South Africa: Information, motivation, and behavioral skills. Journal Of Infection And Public Health 2012, 5: 67-81. PMID: 22341846, DOI: 10.1016/j.jiph.2011.10.008.Peer-Reviewed Original ResearchConceptsTB infection controlRural South African hospitalSouth African hospitalsInfection controlHIV statusAfrican hospitalsTuberculosis infection controlDrug-resistant tuberculosisBehavioral skillsCough hygieneSocial support itemsPresent studyRural South AfricaResource-limited facilitiesHigh-risk areasAnonymous questionnaireIMB modelTuberculosisRespondents' knowledgeSuch interventionsHospitalHCWsIC practicesMost respondentsSocial support
2011
Integration of Antiretroviral Therapy with Tuberculosis Treatment
Abdool Karim S, Naidoo K, Grobler A, Padayatchi N, Baxter C, Gray AL, Gengiah T, Gengiah S, Naidoo A, Jithoo N, Nair G, El-Sadr WM, Friedland G, Abdool Karim Q. Integration of Antiretroviral Therapy with Tuberculosis Treatment. New England Journal Of Medicine 2011, 365: 1492-1501. PMID: 22010915, PMCID: PMC3233684, DOI: 10.1056/nejmoa1014181.Peer-Reviewed Original ResearchConceptsImmune reconstitution inflammatory syndromeT-cell countsEarly ART groupLater-ART groupInitiation of ARTAntiretroviral therapyTuberculosis treatmentIncidence rateCubic millimeterAdverse eventsRisk of IRISHuman immunodeficiency virus (HIV) infectionReconstitution inflammatory syndromeMedian viral loadImmunodeficiency virus infectionAIDS-free survivalRisk of AIDSHigher CD4Median CD4Inflammatory syndromeAmbulatory patientsImmunodeficiency syndromeViral loadContinuation phaseAntiretroviral drugsTuberculosis infection control in rural South Africa: survey of knowledge, attitude and practice in hospital staff
Kanjee Z, Catterick K, Moll AP, Amico KR, Friedland GH. Tuberculosis infection control in rural South Africa: survey of knowledge, attitude and practice in hospital staff. Journal Of Hospital Infection 2011, 79: 333-338. PMID: 21978608, DOI: 10.1016/j.jhin.2011.06.017.Peer-Reviewed Original ResearchConceptsMDR-TB/XDRHuman immunodeficiency virus statusRural South African hospitalNosocomial TB transmissionStigma of TBTuberculosis infection controlTB/HIVDrug-resistant TBInfection control knowledgeHealth informationSouth African hospitalsSurvey of knowledgeBehavioral change interventionsTB-ICTB infectionXDR-TBTB deathsTB transmissionVirus statusHealthcare workersAfrican hospitalsInfection controlHospital staffRural South AfricaBaseline assessmentPrevalence of methicillin-resistant Staphylococcus aureus nasal carriage among hospitalised patients with tuberculosis in rural KwaZulu-Natal
Heysell SK, Shenoi SV, Catterick K, Thomas TA, Friedland G. Prevalence of methicillin-resistant Staphylococcus aureus nasal carriage among hospitalised patients with tuberculosis in rural KwaZulu-Natal. South African Medical Journal 2011, 101: 332-334. PMID: 21837877, PMCID: PMC3628595, DOI: 10.7196/samj.4462.Peer-Reviewed Original ResearchConceptsMethicillin-resistant Staphylococcus aureusTB wardsNasal carriageMRSA isolatesNasal swabsImpact of MRSAMethicillin-resistant Staphylococcus aureus nasal carriageStaphylococcus aureus nasal carriageLow CD4 countRural African hospitalAureus nasal carriageHours of admissionMRSA nasal carriageGovernment district hospitalsStandard disk diffusionImportant nosocomial pathogenRural KwaZulu-NatalAdmission swabCD4 countHospitalised patientsMRSA carriageNosocomial acquisitionTB patientsPrevious hospitalisationMedical chartsRapid Diagnosis of Tuberculosis and Multidrug Resistance by the Microscopic-Observation Drug-Susceptibility Assay
Shah NS, Moodley P, Babaria P, Moodley S, Ramtahal M, Richardson J, Heysell S, Li X, Moll A, Friedland G, Sturm AW, Gandhi NR. Rapid Diagnosis of Tuberculosis and Multidrug Resistance by the Microscopic-Observation Drug-Susceptibility Assay. American Journal Of Respiratory And Critical Care Medicine 2011, 183: 1427-1433. PMID: 21297071, DOI: 10.1164/rccm.201009-1449oc.Peer-Reviewed Original ResearchConceptsDrug susceptibility testingMDR-TB diagnosisMDR-TBHIV statusMultidrug-resistant (MDR) TBProportion methodRapid diagnosisProspective diagnostic accuracy studyAdult TB suspectsMicroscopic-Observation DrugReference standard cultureMedian CD4 countPatient's HIV statusHIV prevalence settingsIndirect proportion methodMycobacterial growth indicator tube (MGIT) cultureMedian turnaround timeResource-limited settingsReference standardDiagnostic accuracy studiesCD4 countMycobacterium tuberculosis detectionConsecutive adultsTB suspectsHIV prevalence
2010
The SAPIT trial provides essential evidence on risks and benefits of integrated and sequential treatment of HIV and tuberculosis
Karim Q, Karim S, Baxter C, Friedland G, Gengiah T, Gray A, Grobler A, Naidoo K, Padayatchi N, El-Sadr W. The SAPIT trial provides essential evidence on risks and benefits of integrated and sequential treatment of HIV and tuberculosis. South African Medical Journal 2010, 100: 808-809. PMID: 21414268, DOI: 10.7196/samj.4621.Peer-Reviewed Original ResearchInfectious Disease Comorbidities Adversely Affecting Substance Users With HIV: Hepatitis C and Tuberculosis
Friedland G. Infectious Disease Comorbidities Adversely Affecting Substance Users With HIV: Hepatitis C and Tuberculosis. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2010, 55: s37-s42. PMID: 21045598, PMCID: PMC4505738, DOI: 10.1097/qai.0b013e3181f9c0b6.Peer-Reviewed Original ResearchConceptsHepatitis CDrug interactionsDrug usersDrug useActive screening programsSpecial clinical challengeIsoniazid preventive therapySubstance abusersInjection drug usePharmacodynamic drug interactionsDrug-resistant organismsTreatment of tuberculosisInfectious disease comorbiditiesHIV/AIDSPreventive therapyTreatment initiationComorbid conditionsMedication adherenceHIV pandemicScreening programClinical challengeClinician expertiseTherapeutic successClinical consequencesInfection controlTreatment of medical, psychiatric, and substance-use comorbidities in people infected with HIV who use drugs
Altice FL, Kamarulzaman A, Soriano VV, Schechter M, Friedland GH. Treatment of medical, psychiatric, and substance-use comorbidities in people infected with HIV who use drugs. The Lancet 2010, 376: 367-387. PMID: 20650518, PMCID: PMC4855280, DOI: 10.1016/s0140-6736(10)60829-x.Peer-Reviewed Original ResearchMeSH KeywordsAIDS-Related Opportunistic InfectionsAnti-HIV AgentsAntipsychotic AgentsAntitubercular AgentsAntiviral AgentsBacterial InfectionsComorbidityCriminal LawDrug InteractionsDrug Resistance, BacterialEvidence-Based MedicineHepatitis, Viral, HumanHIV InfectionsHumansMedication AdherenceMental DisordersNarcoticsPrisonersSubstance-Related DisordersTuberculosisConceptsSubstance use disordersDrug usersAntiretroviral therapyViral hepatitisHIV treatmentHealth of HIVPharmacokinetic drug interactionsSubstance use comorbiditiesMedication-assisted therapyEvidence-based treatmentsDrug-resistant strainsHealth-related outcomesHealth service deliveryInfectious complicationsMultiple comorbiditiesHIV infectionPsychiatric comorbidityPoor adherenceClinical managementCardiovascular diseaseInadequate prescriptionCongregate settingsDrug interactionsComorbiditiesHIVTransmission of Drug-Susceptible and Drug-Resistant Tuberculosis and the Critical Importance of Airborne Infection Control in the Era of HIV Infection and Highly Active Antiretroviral Therapy Rollouts
Shenoi SV, Escombe AR, Friedland G. Transmission of Drug-Susceptible and Drug-Resistant Tuberculosis and the Critical Importance of Airborne Infection Control in the Era of HIV Infection and Highly Active Antiretroviral Therapy Rollouts. Clinical Infectious Diseases 2010, 50: s231-s237. PMID: 20397953, PMCID: PMC3029014, DOI: 10.1086/651496.Peer-Reviewed Original ResearchConceptsInfection control strategiesResource-limited settingsHIV infectionInfection controlActive antiretroviral therapy rolloutHuman immunodeficiency virus (HIV) infectionAntiretroviral therapy rolloutTransmission of drugDrug-resistant TBImmunodeficiency virus infectionDrug-resistant tuberculosisHealth care workersAirborne infection controlNosocomial transmissionTuberculosis careVirus infectionCare workersInfectionCurrent outbreakHigh rateTBPotential benefitsMorbidityHIVTuberculosisTiming of Initiation of Antiretroviral Drugs during Tuberculosis Therapy
Abdool Karim S, Naidoo K, Grobler A, Padayatchi N, Baxter C, Gray A, Gengiah T, Nair G, Bamber S, Singh A, Khan M, Pienaar J, El-Sadr W, Friedland G, Abdool Karim Q. Timing of Initiation of Antiretroviral Drugs during Tuberculosis Therapy. New England Journal Of Medicine 2010, 362: 697-706. PMID: 20181971, PMCID: PMC3076221, DOI: 10.1056/nejmoa0905848.Peer-Reviewed Original ResearchMeSH KeywordsAdultAIDS-Related Opportunistic InfectionsAnti-Retroviral AgentsAntitubercular AgentsCD4 Lymphocyte CountDrug Administration ScheduleDrug Therapy, CombinationFemaleFollow-Up StudiesHIVHIV InfectionsHumansKaplan-Meier EstimateMaleMiddle AgedPatient ComplianceRNA, ViralTuberculosisViral LoadYoung AdultConceptsSequential therapy groupHuman immunodeficiency virusAntiretroviral therapyRate of deathTuberculosis therapyHIV infectionDaily antiretroviral regimenIntegrated antiretroviral therapyIntegration of tuberculosisStandard tuberculosis therapyPositive sputum smearPrimary end pointSafety Monitoring CommitteeDiagnosis of tuberculosisAcid-fast bacilliTiming of initiationAntiretroviral regimenAdverse eventsHIV servicesImmunodeficiency virusAntiretroviral drugsSputum smearStudy groupPatientsCell count
2009
Tuberculosis Immune Reconstitution Inflammatory Syndrome: Drug Resistance and the Critical Need for Better Diagnostics
Friedland G. Tuberculosis Immune Reconstitution Inflammatory Syndrome: Drug Resistance and the Critical Need for Better Diagnostics. Clinical Infectious Diseases 2009, 48: 677-679. PMID: 19191656, DOI: 10.1086/596765.Peer-Reviewed Original Research