2024
Sex differences in binge drinking-related higher morning cortisol levels and in prospective association with future alcohol intake
McGowan C, Krah M, Fogelman N, Seo D, Sinha R. Sex differences in binge drinking-related higher morning cortisol levels and in prospective association with future alcohol intake. Alcohol And Alcoholism 2024, 59: agae047. PMID: 39053499, DOI: 10.1093/alcalc/agae047.Peer-Reviewed Original ResearchConceptsMorning cortisol levelsCortisol levelsHigher morning cortisol levelsHypothalamic-pituitary-adrenal (HPA) axisSex differencesReports of alcohol consumptionProblematic drinking behaviorAlcohol consumptionAverage cortisol levelsBasal cortisol levelsAlcohol intakeHeavy alcohol useChronic alcohol consumptionHPA axisDrinking behaviorNeuroimaging scansPeripheral cortisolAlcohol useStress systemBinge drinkingMorning cortisolStress hormonesMorning plasma cortisolBingeNon-significant relationshipNeural Correlates of Stress and Alcohol Cue-Induced Alcohol Craving and of Future Heavy Drinking: Evidence of Sex Differences
Radoman M, Fogelman N, Lacadie C, Seo D, Sinha R. Neural Correlates of Stress and Alcohol Cue-Induced Alcohol Craving and of Future Heavy Drinking: Evidence of Sex Differences. American Journal Of Psychiatry 2024, 181: 412-422. PMID: 38706332, PMCID: PMC11117176, DOI: 10.1176/appi.ajp.20230849.Peer-Reviewed Original ResearchConceptsAlcohol use disorderPercentage of heavy drinking daysNeural correlates of stressCue-induced cravingHeavy drinking daysAlcohol cravingSex differencesCorrelates of stressDrinking daysAlcohol cue-induced cravingCue-induced alcohol cravingBed nucleus of the stria terminalisSubgenual anterior cingulate cortexAssessment of alcohol cravingHeavy drinkingAlcohol cue reactivityAssociated with poor treatment outcomesCue-induced responsesNeutral cue exposureAssociated with hypoactivationTreatment-seeking adultsHeavy drinking outcomesEvidence of sex differencesVoxel-based regression analysisAnterior cingulate cortex
2013
Neural correlates of preparatory and regulatory control over positive and negative emotion
Seo D, Olman CA, Haut KM, Sinha R, MacDonald AW, Patrick CJ. Neural correlates of preparatory and regulatory control over positive and negative emotion. Social Cognitive And Affective Neuroscience 2013, 9: 494-504. PMID: 23887812, PMCID: PMC3989138, DOI: 10.1093/scan/nst115.Peer-Reviewed Original ResearchConceptsLateral prefrontal cortexEmotion regulationPrefrontal cortexGreater activationBrain activityCingulate cortexBilateral anterior prefrontal cortexRight lateral prefrontal cortexNegative emotion regulationActive emotion regulationCommon brain regionsAnterior prefrontal cortexVentromedial prefrontal cortexDorsomedial prefrontal cortexNegative emotional statesInferior parietal lobeFunctional magnetic resonanceBilateral dorsomedial prefrontal cortexPosterior cingulate cortexAnterior cingulate cortexMain effectRight precentral gyrusEmotional valencePositive emotionsNegative emotionsDisrupted Ventromedial Prefrontal Function, Alcohol Craving, and Subsequent Relapse Risk
Seo D, Lacadie CM, Tuit K, Hong KI, Constable RT, Sinha R. Disrupted Ventromedial Prefrontal Function, Alcohol Craving, and Subsequent Relapse Risk. JAMA Psychiatry 2013, 70: 727-739. PMID: 23636842, PMCID: PMC3788824, DOI: 10.1001/jamapsychiatry.2013.762.Peer-Reviewed Original ResearchConceptsHealthy control subjectsAD patientsControl subjectsInpatient treatmentAlcohol cravingAlcohol cuesBrain responsesRelapse riskAlcohol relapseHospital-based research unitAnterior cingulate cortex activationAlcohol-related cuesCommunity mental health centerVentromedial prefrontal functionChronic relapsing illnessVentromedial prefrontal cortexStress-induced cravingAbstinent alcohol-dependent patientsFunctional magnetic resonanceMental health centersAlcohol-dependent patientsSubsequent relapse riskNeural correlatesNeutral trialsHazard ratio
2011
Circulating glucose levels modulate neural control of desire for high-calorie foods in humans
Page KA, Seo D, Belfort-DeAguiar R, Lacadie C, Dzuira J, Naik S, Amarnath S, Constable RT, Sherwin RS, Sinha R. Circulating glucose levels modulate neural control of desire for high-calorie foods in humans. Journal Of Clinical Investigation 2011, 121: 4161-4169. PMID: 21926468, PMCID: PMC3195474, DOI: 10.1172/jci57873.Peer-Reviewed Original ResearchConceptsHigh-calorie foodsGlucose levelsHyperinsulinemic euglycemic-hypoglycemic clampsBrain regionsFunctional MRIMedial prefrontal cortexMedial prefrontal cortex activationRisk of overeatingLevels of glucosePostprandial reductionPrefrontal cortex activationObese subjectsNonobese individualsMild hypoglycemiaWorldwide epidemicCortex activationPrefrontal cortexFood cuesFood motivationFood stimuliNeural controlObesityInhibitory controlBehavioral measuresVisual cues
2010
Sex differences in neural responses to stress and alcohol context cues
Seo D, Jia Z, Lacadie CM, Tsou KA, Bergquist K, Sinha R. Sex differences in neural responses to stress and alcohol context cues. Human Brain Mapping 2010, 32: 1998-2013. PMID: 21162046, PMCID: PMC3236497, DOI: 10.1002/hbm.21165.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexMedial prefrontal cortexRostral anterior cingulate cortexAlcohol cue exposureOrbitofrontal cortexContext cuesNeural responsesFunctional magnetic resonance imagingSex differencesVentral striatum activityLeft dorsal striatumMiddle frontal gyrusMedial orbitofrontal cortexAlcohol-related behaviorsStress-related activationCognitive processingVentromedial PFCNeural correlatesSex-specific vulnerabilityNeural processingPersonalized stressStriatum activityAnterior insulaBrain responsesFrontal gyrus