2020
Predicting outcomes following second intent healing of periocular surgical defects
Kibbi N, Khan Y, Leffell DJ, Christensen SR, Suozzi KC. Predicting outcomes following second intent healing of periocular surgical defects. Archives Of Dermatological Research 2020, 313: 483-489. PMID: 32833078, DOI: 10.1007/s00403-020-02122-w.Peer-Reviewed Original ResearchConceptsMohs micrographic surgeryMedial canthusSingle academic surgical centerAcademic surgical centerConclusionsThis retrospective studyMedial canthal lesionAverage defect diameterMethodsRetrospective analysisTumor characteristicsPeriocular tumorsRetrospective studyPoor outcomePeriocular lesionsSurgical centersMicrographic surgeryWorse outcomesAnatomic locationAimThe purposeScar outcomeLarge lesionsUpper eyelidEyelid marginLid marginSurgical defectsLower eyelid
2019
Photodynamic therapy for cutaneous squamous cell carcinoma in situ: Impact of anatomic location, tumor diameter, and incubation time on effectiveness
Kibbi N, Zhang Y, Leffell DJ, Christensen SR. Photodynamic therapy for cutaneous squamous cell carcinoma in situ: Impact of anatomic location, tumor diameter, and incubation time on effectiveness. Journal Of The American Academy Of Dermatology 2019, 82: 1124-1130. PMID: 31712171, DOI: 10.1016/j.jaad.2019.10.079.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAminolevulinic AcidAnalysis of VarianceBiopsy, NeedleCarcinoma in SituCarcinoma, Squamous CellCohort StudiesDisease-Free SurvivalFemaleHumansImmunohistochemistryLogistic ModelsMaleMiddle AgedMultivariate AnalysisNeoplasm InvasivenessNeoplasm StagingPhotochemotherapyPrognosisRetrospective StudiesSkin NeoplasmsSurvival AnalysisTreatment OutcomeTumor BurdenConceptsCutaneous squamous cell carcinomaALA incubation timeSquamous cell carcinomaTumor diameterALA-PDTSubsequent recurrenceCell carcinomaAnatomic locationInitial complete response ratePhotodynamic therapyCases of SCCISMultivariate analysis factorsComplete response rateMedical record reviewEffectiveness of PDTPatient demographicsClinical responseMedian timeRetrospective reviewRecord reviewRetrospective studyTreatment detailsSingle institutionEffective treatmentResponse rateOptical Spectroscopy as a Method for Skin Cancer Risk Assessment
Rodriguez‐Diaz E, Manolakos D, Christman H, Bonning MA, Geisse JK, A'Amar OM, Leffell DJ, Bigio IJ. Optical Spectroscopy as a Method for Skin Cancer Risk Assessment. Photochemistry And Photobiology 2019, 95: 1441-1445. PMID: 31287160, DOI: 10.1111/php.13140.Peer-Reviewed Original Research
2017
Cross-sectional assessment of ultraviolet radiation–related behaviors among young people after a diagnosis of melanoma or basal cell carcinoma
Ferrucci LM, Cartmel B, Clare RA, Choy CC, Kershaw T, Leffell DJ, Mayne ST. Cross-sectional assessment of ultraviolet radiation–related behaviors among young people after a diagnosis of melanoma or basal cell carcinoma. Journal Of The American Academy Of Dermatology 2017, 79: 149-152. PMID: 29291957, PMCID: PMC6004335, DOI: 10.1016/j.jaad.2017.12.056.Peer-Reviewed Original ResearchWell‐differentiated neuroendocrine tumors in skin: Terminology and diagnostic utility of cytokeratin 5/6 and p63
Panse G, Cowper SE, Leffell DJ, Pulitzer M, Ko CJ. Well‐differentiated neuroendocrine tumors in skin: Terminology and diagnostic utility of cytokeratin 5/6 and p63. Journal Of Cutaneous Pathology 2017, 44: 557-562. PMID: 28417484, DOI: 10.1111/cup.12952.Peer-Reviewed Original ResearchConceptsCutaneous adnexal neoplasmsAdnexal neoplasmsNeuroendocrine tumorsAdnexal tumorsBenign skin adnexal tumorCutaneous adnexal tumorsAggressive metastatic diseaseLow-grade tumorsSkin adnexal tumorsMajority of casesMetastatic diseaseMetastatic adenocarcinomaCarcinoid tumorsCytokeratin 5/6Diagnostic challengeDifferential diagnosisImmunohistochemical stainsCK5/6Diagnostic utilityPrimary siteTumorsNeoplasmsFirst signWDNETsP63
2016
Histopathologic features of multiple cutaneous squamous cell carcinomas of the lower extremity
Munday WR, Leffell DJ, McNiff JM, Ko CJ. Histopathologic features of multiple cutaneous squamous cell carcinomas of the lower extremity. Journal Of Cutaneous Pathology 2016, 43: 759-765. PMID: 27220356, DOI: 10.1111/cup.12738.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaMultiple squamous cell carcinomasCutaneous squamous cell carcinomaHistopathologic featuresCell carcinomaLower extremitiesMultiple cutaneous squamous cell carcinomasRetrospective chart reviewAmerican Joint CommitteeCancer staging criteriaDistinct clinical subtypesChart reviewPerineural invasionActinic keratosisStaging criteriaClinical subtypesMost lesionsStage IJoint CommitteeStage IIKeratoacanthomaPatientsCarcinomaTumorsSubtypes
2015
Randomized comparison of the safety of Flublok® versus licensed inactivated influenza vaccine in healthy, medically stable adults ≥50 years of age
Izikson R, Leffell DJ, Bock SA, Patriarca PA, Post P, Dunkle LM, Cox MM. Randomized comparison of the safety of Flublok® versus licensed inactivated influenza vaccine in healthy, medically stable adults ≥50 years of age. Vaccine 2015, 33: 6622-6628. PMID: 26529070, DOI: 10.1016/j.vaccine.2015.10.097.Peer-Reviewed Original ResearchConceptsYears of ageVaccine groupInfluenza vaccineHypersensitivity reactionsPossible hypersensitivityOverall adverse event profileUnsolicited adverse eventsInactivated influenza vaccineAdverse event profileSeasonal influenza vaccineIncidence of hypersensitivityAdverse event termsAdverse eventsRandomized comparisonEvent profileClinical criteriaClinical trialsStable adultsAfluriaCase recordsHealthy adultsTreatment assignmentHypersensitivityVaccineFlublokFamily history of skin cancer is associated with early-onset basal cell carcinoma independent of MC1R genotype
Berlin NL, Cartmel B, Leffell DJ, Bale AE, Mayne ST, Ferrucci LM. Family history of skin cancer is associated with early-onset basal cell carcinoma independent of MC1R genotype. Cancer Epidemiology 2015, 39: 1078-1083. PMID: 26381319, PMCID: PMC4679454, DOI: 10.1016/j.canep.2015.09.005.Peer-Reviewed Original ResearchConceptsEarly-onset basal cell carcinomaBasal cell carcinomaFamily historySkin cancerAge of onsetLifestyle factorsBenign skin conditionsStrong risk factorFirst-degree relativesMC1R genotypeCell carcinomaRisk factorsAge 40High riskLifestyle characteristicsAge 50Particular malignancySkin conditionsBCC casesCancerGenetic susceptibilitySaliva samplesMultivariate modelIndividual riskAffected relativesA Strategy for the Successful Management of Dermatofibrosarcoma Protuberans
Goldberg C, Hoang D, McRae M, Chung C, Leffell DJ, Narayan D. A Strategy for the Successful Management of Dermatofibrosarcoma Protuberans. Annals Of Plastic Surgery 2015, 74: 80-84. PMID: 23788146, DOI: 10.1097/sap.0b013e3182898692.Peer-Reviewed Original ResearchConceptsSurgical excisionPositive marginsDermatofibrosarcoma protuberansMohs surgeryNational Comprehensive Cancer Network guidelinesDisease recurrence/persistenceMargin sizeClear histological marginsComplications of reconstructionInitial surgical resectionRecurrence/persistenceTraditional surgical excisionSoft tissue sarcomasMethod of treatmentExcision patientsHistological marginsSurgery groupSubclinical involvementSurgical resectionMargin statusDistant metastasisNetwork guidelinesTissue sarcomasClinical variablesTumor resection
2014
Mesenchymal stromal cells form vascular tubes when placed in fibrin sealant and accelerate wound healing in vivo
Mendez JJ, Ghaedi M, Sivarapatna A, Dimitrievska S, Shao Z, Osuji CO, Steinbacher DM, Leffell DJ, Niklason LE. Mesenchymal stromal cells form vascular tubes when placed in fibrin sealant and accelerate wound healing in vivo. Biomaterials 2014, 40: 61-71. PMID: 25433608, PMCID: PMC4268422, DOI: 10.1016/j.biomaterials.2014.11.011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsBiomarkersCollagenDisease Models, AnimalEnzyme-Linked Immunosorbent AssayFemaleFibrin Tissue AdhesiveFibroblast Growth Factor 2Flow CytometryHumansImmunohistochemistryMaleMesenchymal Stem CellsMice, Inbred C57BLMiddle AgedNeovascularization, PhysiologicReal-Time Polymerase Chain ReactionRheologySubcutaneous TissueWound HealingConceptsAdipose-derived mesenchymal stromal cellsMesenchymal stromal cellsGranulation tissueStromal cellsPericyte marker NG2VE-cadherinWound healingPublic health problemMarkers of endotheliumDays of healingSubcutaneous injectionPresence of bFGFFibrin gelAmount of bFGFHAT-MSCsFibrin sealantWound sizeHealth problemsChronic woundsConfocal imaging analysisInsufficient angiogenesis
2013
Cutaneous squamous cell carcinomas of the lower extremity: A distinct subset of squamous cell carcinomas
Kim C, Ko CJ, Leffell DJ. Cutaneous squamous cell carcinomas of the lower extremity: A distinct subset of squamous cell carcinomas. Journal Of The American Academy Of Dermatology 2013, 70: 70-74. PMID: 24210370, DOI: 10.1016/j.jaad.2013.09.026.Peer-Reviewed Original ResearchConceptsCutaneous squamous cell carcinomaSquamous cell carcinomaLower extremitiesCell carcinomaClinical featuresIncidence of SCCPrevalence of SCCDistinct subsetsDistinctive clinical featuresNumber of patientsBasal cell carcinomaClinical outcomesSquamous cellsBiologic behaviorSame patientGeneral populationPatientsCarcinomaStudy periodAdditional studiesDefinitive conclusionsIncidenceExtremitiesOutcomesTreatmentSingle v. multiple measures of skin carotenoids by resonance Raman spectroscopy as a biomarker of usual carotenoid status
Scarmo S, Cartmel B, Lin H, Leffell DJ, Ermakov IV, Gellermann W, Bernstein PS, Mayne ST. Single v. multiple measures of skin carotenoids by resonance Raman spectroscopy as a biomarker of usual carotenoid status. British Journal Of Nutrition 2013, 110: 911-917. PMID: 23351238, PMCID: PMC3696054, DOI: 10.1017/s000711451200582x.Peer-Reviewed Original ResearchConceptsSkin carotenoid statusRecent sun exposureCarotenoid statusSkin carotenoidsSun exposureRR measuresFruit/vegetable intakeLower carotenoid statusSeason of measurementMean ageNon-invasive methodVegetable intakeInverse associationDietary dataTime pointsSignificant predictorsMultiple measuresPositive associationIntakeBiomarkersPresent studyStatusPredictorsAssociationExposure
2012
Desmoplastic trichoepithelioma with perineural involvement: a series of seven cases
Jedrych J, Leffell D, McNiff JM. Desmoplastic trichoepithelioma with perineural involvement: a series of seven cases. Journal Of Cutaneous Pathology 2012, 39: 317-323. PMID: 22335590, DOI: 10.1111/j.1600-0560.2012.01876.x.Peer-Reviewed Original ResearchConceptsDesmoplastic trichoepitheliomaPerineural involvementDesmoplastic stromaMicrocystic adnexal carcinomaBasal cell carcinomaBenign epithelial proliferationsP75 neurotrophin receptorMiddle-aged womenBenign follicular tumorsCK20-positive cellsSmall dermal nervesAdnexal carcinomaCell carcinomaTumor recurrenceTypical presentationBasaloid epitheliumDermal nervesPerineural spaceNeurotrophin receptorBasaloid cellsEpithelial proliferationDermal proliferationDiffuse expressionFollicular tumorsPatients
2010
Noninvasive assessment of dermal carotenoids as a biomarker of fruit and vegetable intake
Mayne ST, Cartmel B, Scarmo S, Lin H, Leffell DJ, Welch E, Ermakov I, Bhosale P, Bernstein PS, Gellermann W. Noninvasive assessment of dermal carotenoids as a biomarker of fruit and vegetable intake. American Journal Of Clinical Nutrition 2010, 92: 794-800. PMID: 20685953, PMCID: PMC3133234, DOI: 10.3945/ajcn.2010.29707.Peer-Reviewed Original ResearchConceptsIntraclass correlation coefficientDermal carotenoidsDermal biopsiesRR measuresBiomarkers of fruitDietary carotenoid intakeVegetable intakeCarotenoid statusCarotenoid intakeStudy of nutritionNoninvasive assessmentBiopsyBiomarkersSkin pigmentationTotal carotenoidsHuman skinIntakeWkInner armLycopeneValid methodArmSignificant correlations of dermal total carotenoids and dermal lycopene with their respective plasma levels in healthy adults
Scarmo S, Cartmel B, Lin H, Leffell DJ, Welch E, Bhosale P, Bernstein PS, Mayne ST. Significant correlations of dermal total carotenoids and dermal lycopene with their respective plasma levels in healthy adults. Archives Of Biochemistry And Biophysics 2010, 504: 34-39. PMID: 20637178, PMCID: PMC2957565, DOI: 10.1016/j.abb.2010.07.004.Peer-Reviewed Original ResearchConceptsHuman skin photoprotectionRespective plasma levelsHigh-performance liquid chromatographyHuman skinPlasma levelsBlood samplesHealthy humansHealthy adultsHydrocarbon carotenoidsDermal biopsiesSkin photoprotectionSimilar proportionsSkinSignificant correlationPerformance liquid chromatographyIndividual carotenoid contentTotal carotenoidsRelative levelsLycopeneLiquid chromatographyBiopsyPlasmaLuteinSquamoid Eccrine Ductal Carcinoma: A Case Report and Review of the Literature
Terushkin E, Leffell DJ, Futoryan T, Cowper S, Lazova R. Squamoid Eccrine Ductal Carcinoma: A Case Report and Review of the Literature. American Journal Of Dermatopathology 2010, 32: 287-292. PMID: 20010402, DOI: 10.1097/dad.0b013e3181b623c4.Peer-Reviewed Case Reports and Technical NotesConceptsDuctal carcinomaShave biopsyEccrine ductal carcinomaInitial shave biopsySuperficial shave biopsiesMohs micrographic surgeryRare adnexal tumorTreatment guidelinesCase reportDiagnostic challengeMicrographic surgeryBiologic behaviorComplete excisionAdnexal tumorsImmunohistochemical approachBiopsyCarcinomaRare variantsTumorsDiagnostic purposesPatientsSurgeryNeoplasmsExcisionCancer
2009
Adenosquamous carcinoma: a report of nine cases with p63 and cytokeratin 5/6 staining
Ko CJ, Leffell DJ, McNiff JM. Adenosquamous carcinoma: a report of nine cases with p63 and cytokeratin 5/6 staining. Journal Of Cutaneous Pathology 2009, 36: 448-452. PMID: 19278431, DOI: 10.1111/j.1600-0560.2008.01083.x.Peer-Reviewed Original ResearchConceptsCytokeratin 5/6Adenosquamous carcinomaPrimary cutaneous originSubset of casesCutaneous originMetastatic adenocarcinomaAppropriate therapyRare tumorGlandular differentiationCytokeratin 7Such tumorsDiffuse positivityLuminal areaTumorsCarcinomaAggressive behaviorP63StainClose associationAdenocarcinomaTherapyLesionsCasesPositivity
2005
Primary cutaneous carcinosarcoma arising in a patient with nevoid basal cell carcinoma syndrome
Bhattacharjee P, Leffell D, McNiff JM. Primary cutaneous carcinosarcoma arising in a patient with nevoid basal cell carcinoma syndrome. Journal Of Cutaneous Pathology 2005, 32: 638-641. PMID: 16176303, DOI: 10.1111/j.0303-6987.2005.00384.x.Peer-Reviewed Original ResearchBilobed transposition flap
Aasi SZ, Leffell DJ. Bilobed transposition flap. Dermatologic Clinics 2005, 23: 55-64. PMID: 15620619, DOI: 10.1016/j.det.2004.08.004.Peer-Reviewed Original Research
2002
Clinical Efficacy of Devices for Nonablative Photorejuvenation
Leffell DJ. Clinical Efficacy of Devices for Nonablative Photorejuvenation. JAMA Dermatology 2002, 138: 1503-1508. PMID: 12437458, DOI: 10.1001/archderm.138.11.1503.Peer-Reviewed Original Research