2024
Sex differences in the distribution and density of regulatory interneurons in the striatum
Van Zandt M, Flanagan D, Pittenger C. Sex differences in the distribution and density of regulatory interneurons in the striatum. Frontiers In Cellular Neuroscience 2024, 18: 1415015. PMID: 39045533, PMCID: PMC11264243, DOI: 10.3389/fncel.2024.1415015.Peer-Reviewed Original ResearchFast spiking interneuronsCholinergic interneuronsDorsal striatumSex differencesTourette syndromeVentral striatumNeuropsychiatric disordersSomatostatin expressionContext of psychopathologyHuman neuropsychiatric disordersBasal ganglia functionInvestigate sex differencesNucleus accumbensCaudate-putamenBehavioral pathologyStriatumSomatostatin-expressing interneuronsStriatal interneuronsGABAergic interneuronsMale miceStereological quantificationFemale miceInterneuronsDisordersAccumbens
2022
White matter abnormalities in the Hdc knockout mouse, a model of tic and OCD pathophysiology
Jindachomthong K, Yang C, Huang Y, Coman D, Rapanelli M, Hyder F, Dougherty J, Frick L, Pittenger C. White matter abnormalities in the Hdc knockout mouse, a model of tic and OCD pathophysiology. Frontiers In Molecular Neuroscience 2022, 15: 1037481. PMID: 36504678, PMCID: PMC9731796, DOI: 10.3389/fnmol.2022.1037481.Peer-Reviewed Original ResearchTourette syndromeDiffusion tensor imagingDorsal striatumKnockout miceFractional anisotropyCortico-basal ganglia circuitryHDC knockout miceWhite matter abnormalitiesIntact mouse brainBiosynthesis of histamineCortical projectionsNeurochemical abnormalitiesPosterior hypothalamusKO miceVocal ticsFunctional abnormalitiesMyelin productionPathological alterationsDTI literatureOCD pathophysiologyMouse brainBrain regionsKO modelAbnormalitiesTensor imaging
2015
Are There Biological Commonalities Among Different Psychiatric Disorders?
Etkin A, Pittenger C. Are There Biological Commonalities Among Different Psychiatric Disorders? 2015, 243-257. DOI: 10.1002/9781118753378.ch15.Peer-Reviewed Original ResearchPsychiatric diseasesDifferent disordersMajor depressive disorderSame brain circuitsDifferent psychiatric disordersAnterior cingulate cortexDorsolateral prefrontal cortexDepressive disorderDorsal striatumPsychiatric disordersCingulate cortexOverlapping symptomatologyBrain circuitsVentral striatumBiological commonalitiesBrain functionPrefrontal cortexDisordersNormal functionDrug addictionStriatumCortexDiseaseDiagnosisSymptomatology
2013
Global Resting-State Functional Magnetic Resonance Imaging Analysis Identifies Frontal Cortex, Striatal, and Cerebellar Dysconnectivity in Obsessive-Compulsive Disorder
Anticevic A, Hu S, Zhang S, Savic A, Billingslea E, Wasylink S, Repovs G, Cole MW, Bednarski S, Krystal JH, Bloch MH, Li CS, Pittenger C. Global Resting-State Functional Magnetic Resonance Imaging Analysis Identifies Frontal Cortex, Striatal, and Cerebellar Dysconnectivity in Obsessive-Compulsive Disorder. Biological Psychiatry 2013, 75: 595-605. PMID: 24314349, PMCID: PMC3969771, DOI: 10.1016/j.biopsych.2013.10.021.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderPrefrontal cortexResting-state functional connectivity dataStriatum/nucleus accumbensVentral striatum/nucleus accumbensResting-state functional connectivity studiesVentral anterior cingulate cortexCortico-striatal circuitsMagnetic Resonance Imaging AnalysisAnterior cingulate cortexFunctional connectivity studiesBasal gangliaControl subjectsFunctional connectivity dataAnterior thalamusRight putamenFrontal cortexNucleus accumbensDorsal striatumCerebellar cortexAbnormal neural connectivityCerebellar dysconnectivityCingulate cortexWhole brainFunctional magnetic resonance imaging (fMRI) analysis
2008
Are there Biological Commonalities among Different Psychiatric Disorders?
Pittenger C, Etkin A. Are there Biological Commonalities among Different Psychiatric Disorders? 2008, 243-256. DOI: 10.1002/9780470515167.ch15.Peer-Reviewed Original ResearchPsychiatric disordersPsychiatric conditionsNormal functionDifferent psychiatric disordersAnterior cingulate cortexUnderlying biological abnormalitiesParticular psychiatric conditionsDorsolateral prefrontal cortexCurrent diagnostic schemesClinical aspectsSimilar brain systemsDorsal striatumSomatic illnessPsychiatric diseasesCingulate cortexBiological abnormalitiesBiological commonalitiesDifferent disordersPrefrontal cortexParticular disorderDisordersNeurobiological underpinningsStriatumBrain systemsCortex