2023
Association of clinical characteristics with urine uromodulin in children with chronic kidney disease
Faulkner S, Matheson M, Greenberg J, Garimella P, Furth S, Ix J, Bakhoum C. Association of clinical characteristics with urine uromodulin in children with chronic kidney disease. Pediatric Nephrology 2023, 38: 3859-3862. PMID: 36988691, PMCID: PMC10528151, DOI: 10.1007/s00467-023-05947-5.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseUrine uromodulinUromodulin levelsGlomerular diseaseKidney diseaseEtiology of CKDGraphical abstractA higher resolution versionOlder ageMultivariable linear regressionAge-specific referenceGreater kidney sizeHigh urine concentrationsRelationship of ageConclusionsAmong childrenTubular healthClinical characteristicsMedian eGFRMedian agePrimary outcomeKidney functionKidney sizeMultivariable modelChild CohortUrine concentrationsHealthy adults
2020
The Relationship Between Urine Uromodulin and Blood Pressure Changes: The DASH-Sodium Trial
Bakhoum CY, Anderson CAM, Juraschek SP, Rebholz CM, Appel LJ, Miller ER, Parikh CR, Obeid W, Rifkin DE, Ix JH, Garimella PS. The Relationship Between Urine Uromodulin and Blood Pressure Changes: The DASH-Sodium Trial. American Journal Of Hypertension 2020, 34: 154-156. PMID: 32856709, PMCID: PMC7951043, DOI: 10.1093/ajh/hpaa140.Peer-Reviewed Original ResearchConceptsSystolic blood pressureUrine uromodulinUromodulin levelsBlood pressureSodium dietSalt intakeDASH-Sodium trialHigh sodium dietHigh salt intakeHigh-salt dietSalt-induced hypertensionBlood pressure changesBody mass indexMultivariable linear regressionLoop of HenleHigher baseline levelsThick ascending limbFeeding periodGreater increaseSodium trialSalt dietDietary ApproachesMass indexRandomized trialsSBP change