Chirag Parikh, MD, PhD, FACP
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Biography
Dr. Parikh is an Adjunct Professor of Medicine, section of Nephrology. Currently at Johns Hopkins University, Dr. Parikh continues his research projects and collaborations with F. Perry Wilson, MD, MSCE, the Interim Director of the Program of Applied Translational Research (PATR) and with other faculty and collaborators within PATR.
Dr. Parikh received his MD from Mumbai, India in 1996. His post-graduate training involves Residency in Internal Medicine at Nassau University and SUNY in Stony Brook, NY, and Fellowship in Nephrology and Hypertension at the University of Colorado Health Sciences Center in Denver, CO. He also completed a PhD in Clinical Investigation and Translational Research at University of Colorado Health Sciences Center, Denver, CO in 2003. He is board certified in both Internal Medicine and Nephrology. He has received several awards, including the National Junior Physician Investigator Award from the American Federation of Medical Research and the Outstanding Investigator Award from the Society of Clinical Investigation.
Dr. Parikh conducts an active patient-oriented research program investigating the translational and epidemiological aspects of acute kidney injury (AKI) and other kidney related disorders. His major research interest is developing novel biomarkers of AKI. He is the Principal Investigator of the NIH sponsored TRIBE-AKI consortium that is conducting large studies for validating novel kidney injury biomarkers in setting of cardiac surgery, kidney transplantation, diabetic kidney disease and hepatorenal syndrome. He has authored more than 250 peer-reviewed papers, 50 book chapters and reviews, and he has given more than 50 invited lectures at scientific meetings and academic institutions around the world.
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Education & Training
- PhD
- University of Colorado at Denver (2003)
- MD
- Seth G.S. Medical College (1996)
Research
Overview
Medical Subject Headings (MeSH)
Acute Kidney Injury; Biomarkers, Pharmacological; Biostatistics; Kidney Diseases; Nephrology; Renal Insufficiency; Translational Research, Biomedical
ORCID
0000-0001-9051-7385- View Lab Website
Program of Applied Translation Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Chirag Parikh's published research.
Publications Timeline
A big-picture view of Chirag Parikh's research output by year.
Research Interests
Research topics Chirag Parikh is interested in exploring.
Dennis G Moledina, MD, PhD, FASN
F. Perry Wilson, MD, MSCE
Sherry Mansour, MD, MS
Harlan Krumholz, MD, SM
Jason Greenberg, MD, MHS
Justin Belcher, MD, PhD, FASN
41Publications
2,139Citations
Acute Kidney Injury
Renal Insufficiency
Kidney Diseases
Publications
2024
Kidney Transplant Outcomes From Donors Who Received Dialysis—Reply
Philbrook H, Reese P, Parikh C. Kidney Transplant Outcomes From Donors Who Received Dialysis—Reply. JAMA 2024, 332 PMID: 39495504, DOI: 10.1001/jama.2024.19708.Peer-Reviewed Original ResearchB-243 Validating a highly automated, rapid turnaround urine biomarker assay for diagnosis of acute interstitial nephritis
Obeid W, Moledina D, Parikh C. B-243 Validating a highly automated, rapid turnaround urine biomarker assay for diagnosis of acute interstitial nephritis. Clinical Chemistry 2024, 70: hvae106.600. DOI: 10.1093/clinchem/hvae106.600.Peer-Reviewed Original ResearchConceptsAcute interstitial nephritisDiagnosis of acute interstitial nephritisTNF-aMesoscale DiscoveryCXCL-9Urinary tumor necrosis factor-alphaInterstitial nephritisUrine biomarker assayTumor necrosis factor-alphaNecrosis factor-alphaSpike-recovery analysisFactor-alphaPotential diagnostic biomarkersLevels of QCBiomarker assaysDiagnostic biomarkersAssay diluentDilution linearityNephritisAverage recoverySpiking volumeHospital settingLigand 9UrineDiagnosisAssociation between Left Ventricular Geometry, Systolic Ejection Time, and Estimated Glomerular Filtration Rate in Ambulatory Patients with Preserved Left Ventricular Ejection Fraction
Goeddel L, Navarrete S, Waldron N, D’Amiano A, Faraday N, Lima J, Parikh C, Bandeen-Roche K, Hays A, Brown C. Association between Left Ventricular Geometry, Systolic Ejection Time, and Estimated Glomerular Filtration Rate in Ambulatory Patients with Preserved Left Ventricular Ejection Fraction. Cardiology 2024, 1-11. PMID: 39353411, DOI: 10.1159/000541725.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionTrans thoracic echocardiographyIncreased RWTRelative wall thicknessChronic kidney diseaseLeft ventricular ejection timeSubclinical systolic dysfunctionVentricular ejection fractionCardiac functionSystolic dysfunctionEjection fractionSystolic functionClinical outcomesPreserved left ventricular ejection fractionAmbulatory patientsAssociated with adverse clinical outcomesMeasures of LV geometryEjection timeAssociated with chronic kidney diseaseIncreased oddsMeasures of cardiac functionLV relative wall thicknessSubclinical cardiac dysfunctionIncreased odds of CKDOdds of chronic kidney diseaseAssessment of Renal Vein Stasis Index by Transesophageal Echocardiography During Cardiac Surgery: A Feasibility Study.
Goeddel L, Hernandez M, Koffman L, Slowey C, Muschelli J, Zhou X, Parikh C, Lima J, Bandeen-Roche K, Faraday N, Crainiceanu C, Brown Iv C. Assessment of Renal Vein Stasis Index by Transesophageal Echocardiography During Cardiac Surgery: A Feasibility Study. Anesthesia & Analgesia 2024 PMID: 39312481, DOI: 10.1213/ane.0000000000007161.Peer-Reviewed Original ResearchSex Differences in Hypertension and Its Management Throughout Life
Yeo W, Abraham R, Surapaneni A, Schlosser P, Ballew S, Ozkan B, Flaherty C, Yu B, Bonventre J, Parikh C, Kimmel P, Vasan R, Coresh J, Grams M. Sex Differences in Hypertension and Its Management Throughout Life. Hypertension 2024, 81: 2263-2274. PMID: 39229711, PMCID: PMC11483212, DOI: 10.1161/hypertensionaha.124.22980.Peer-Reviewed Original ResearchAltmetricConceptsPrevalence of hypertensionUncontrolled hypertensionChronic kidney disease progressionPrevalence of uncontrolled hypertensionKidney disease progressionBody mass indexClasses of medicationsSex differencesEstimate sex differencesCoronary heart diseaseHeart failureMass indexAntihypertensive medicationsDisease progressionStudy visitsAtherosclerosis RiskHypertensionHigh riskHypertensive individualsHeart diseaseLife courseCommunity studiesPrevalenceMedicationOccurrence of Low Cardiac Index During Normotensive Periods in Cardiac Surgery: A Prospective Cohort Study Using Continuous Noninvasive Cardiac Output Monitoring.
Goeddel L, Koffman L, Hernandez M, Whitman G, Parikh C, Lima J, Bandeen-Roche K, Zhou X, Muschelli J, Crainiceanu C, Faraday N, Brown C. Occurrence of Low Cardiac Index During Normotensive Periods in Cardiac Surgery: A Prospective Cohort Study Using Continuous Noninvasive Cardiac Output Monitoring. Anesthesia & Analgesia 2024 PMID: 39207928, DOI: 10.1213/ane.0000000000007206.Peer-Reviewed Original ResearchConceptsCentral venous pressurePre-CPBCardiac output monitoringCardiopulmonary bypassProspective cohort studyCardiac surgeryPost-CPBKidney injuryCoronary bypassRisk of postoperative acute kidney injuryCohort studyCardiac outputNoninvasive cardiac output monitoringOutput monitoringBlood pressurePostoperative acute kidney injuryProspective cohort of patientsPaired Wilcoxon rank sum testContinuous cardiac output monitoringPostoperative kidney injuryIsolated coronary bypassLow cardiac indexLow cardiac outputUS Food and Drug AdministrationAssociated with increased riskThe Use of Kidney Disease Improving Global Outcomes AKI Definitions in Retrospective AKI Research: CON
Tamargo C, Parikh C. The Use of Kidney Disease Improving Global Outcomes AKI Definitions in Retrospective AKI Research: CON. Kidney360 2024, 5: 944-947. PMID: 38833306, PMCID: PMC11296551, DOI: 10.34067/kid.0000000000000355.Peer-Reviewed Original ResearchCitationsMeSH KeywordsKidney Transplant Outcomes From Deceased Donors Who Received Dialysis
Wen Y, Mansour S, Srialluri N, Hu D, Philbrook H, Hall I, Doshi M, Mohan S, Reese P, Parikh C. Kidney Transplant Outcomes From Deceased Donors Who Received Dialysis. JAMA 2024, 332: 215-225. PMID: 38780515, PMCID: PMC11117155, DOI: 10.1001/jama.2024.8469.Peer-Reviewed Original ResearchCitationsAltmetricConceptsDeath-censored graft failureKidney transplant recipientsGraft failureDeceased kidney donorsKidney transplantationTransplant recipientsGraft functionDeceased donorsFollow-upHigher risk of delayed graft functionIncidence of delayed graft functionOutcomes of transplant recipientsRisk of delayed graft functionMedian follow-upKidney donorsDelayed graft functionUS organ procurement organizationsKidney transplant outcomesRetrospective cohort studyRecipients of kidneysKidney donationAcute Kidney Injury, Systemic Inflammation, and Long-Term Cognitive Function
Bhatraju P, Zelnick L, Stanaway I, Ikizler T, Menez S, Chinchilli V, Coca S, Kaufman J, Kimmel P, Parikh C, Go A, Siew E, Wurfel M, Himmelfarb J. Acute Kidney Injury, Systemic Inflammation, and Long-Term Cognitive Function. Clinical Journal Of The American Society Of Nephrology 2024, 19: 829-836. PMID: 38728094, PMCID: PMC11254015, DOI: 10.2215/cjn.0000000000000473.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsLong-term cognitive impairmentRisk of long-term cognitive impairmentCognitive impairmentCognitive functionCognitive declineSoluble TNF receptor-1 concentrationsAssociated with poorer cognitive functionModified Mini-Mental Status ExaminationLong-term cognitive functionPoorer cognitive functionMini-Mental Status ExaminationLong-term cognitive declineSystemic inflammationCognitive testsCognitive dysfunctionSerial evaluationMediation analysisPersistent systemic inflammationSystemic inflammatory biomarkersAcute kidney injuryBaseline kidney functionComplication of CKDAssociated with long-term cognitive declineEpisode of AKITNF receptor 1Systematic Review and Meta-Analysis of Urine Neutrophil Gelatinase–Associated Lipocalin for Acute Kidney Injury in Cirrhosis
Puthumana J, Lugon N, Xu Y, Deng Y, Mistry P, Parikh C, Consortium T, Angeli P, Belcher J, Gambino C, Salaheldin M, Treepraertsuk S. Systematic Review and Meta-Analysis of Urine Neutrophil Gelatinase–Associated Lipocalin for Acute Kidney Injury in Cirrhosis. Kidney International Reports 2024, 9: 2278-2281. PMID: 39081737, PMCID: PMC11284356, DOI: 10.1016/j.ekir.2024.04.050.Peer-Reviewed Original ResearchAltmetric
Academic Achievements & Community Involvement
honor Jeff Gray Memorial "Translating to Management in AKI"
National AwardAKI and CRRT 2017 22nd International ConferenceDetails03/09/2017United Stateshonor Dr. MD Motashaw Oration and Award for Research Accomplishment
International AwardSeth G.S. Medical College and KEM HospitalDetails04/24/2013India
News
News
- July 05, 2023
Researchers Find New Way to Diagnose Drug-Induced Kidney Inflammation
- November 13, 2018
MD Candidate Jeremy Puthumana Named to Forbes "30 Under 30" List
- February 20, 2018
Medical faculty elected to the American Society for Clinical Investigation
- December 25, 2017
Parikh receives recognition for nephrology work
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