2021
An increase in VGF expression through a rapid, transcription-independent, autofeedback mechanism improves cognitive function
Lin W, Zhao Y, Li Z, Zheng S, Zou J, Warren N, Bali P, Wu J, Xing M, Jiang C, Tang Y, Salton S, Ye X. An increase in VGF expression through a rapid, transcription-independent, autofeedback mechanism improves cognitive function. Translational Psychiatry 2021, 11: 383. PMID: 34238925, PMCID: PMC8266826, DOI: 10.1038/s41398-021-01489-2.Peer-Reviewed Original ResearchConceptsDense-core vesiclesTLQP-62VGF-derived peptide TLQP-62Cognitive functionGranin familyDepression-like behaviorRelease of neuropeptidesGranin proteinsHippocampus-dependent learningCultured primary neuronsLuciferase-based reporter assayGranin family proteinsTranscription-independent inductionNeuronal activationMood disordersAutofeedback mechanismNeuronal activityPrimary neuronsVGF expressionMice exhibitMood stabilityAlzheimer's diseaseBrain tissueMRNA expressionNeurodegenerative diseases
2017
VGF function in depression and antidepressant efficacy
Jiang C, Lin WJ, Sadahiro M, Labonté B, Menard C, Pfau ML, Tamminga CA, Turecki G, Nestler EJ, Russo SJ, Salton SR. VGF function in depression and antidepressant efficacy. Molecular Psychiatry 2017, 23: 1632-1642. PMID: 29158577, PMCID: PMC5962361, DOI: 10.1038/mp.2017.233.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntidepressive AgentsBrain-Derived Neurotrophic FactorDepressionDepressive DisorderDown-RegulationFemaleHippocampusHumansKetamineMaleMiceMice, Inbred C57BLMiddle AgedNerve Growth FactorsNeuronsNeuropeptidesNucleus AccumbensReceptors, AMPASex FactorsSignal TransductionStress, PsychologicalTOR Serine-Threonine KinasesUp-RegulationConceptsChronic social defeat stressDepression-like behaviorBrain-derived neurotrophic factorSocial defeat stressNucleus accumbensAntidepressant efficacyAntidepressant responseDefeat stressFloxed micePro-depressant effectsRapid antidepressant efficacyBDNF/TrkBIsoxazolepropionic acid (AMPA) receptorsWild-type miceDepressed human subjectsBDNF translationTLQP-62VGF levelsAAV-CreAntidepressant behaviorNeurotrophic factorSwim testDorsal hippocampusInhibitory interneuronsVGF expression