2024
The endogenous opioid system in the medial prefrontal cortex mediates ketamine’s antidepressant-like actions
Jiang C, DiLeone R, Pittenger C, Duman R. The endogenous opioid system in the medial prefrontal cortex mediates ketamine’s antidepressant-like actions. Translational Psychiatry 2024, 14: 90. PMID: 38346984, PMCID: PMC10861497, DOI: 10.1038/s41398-024-02796-0.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexAction of ketamineEndogenous opioid systemAntidepressant-like actionOpioid systemB-endorphinKetamine treatmentAntidepressant-like actions of ketamineBehavioral actions of ketamineAntidepressant actions of ketamineBehavioral effects of ketamineSingle dose of ketamineAntidepressant-like effectsLevels of B-endorphinAcute systemic administrationEffects of ketamineDose of ketamineOpioid receptor antagonistAntidepressant actionPrefrontal cortexActivation of opioid receptorsBehavioral effectsBehavioral actionsCompetitive opioid receptor antagonistOpioid receptors
2019
Grape‐derived polyphenols produce antidepressant effects via VGF‐ and BDNF‐dependent mechanisms
Jiang C, Sakakibara E, Lin W, Wang J, Pasinetti GM, Salton SR. Grape‐derived polyphenols produce antidepressant effects via VGF‐ and BDNF‐dependent mechanisms. Annals Of The New York Academy Of Sciences 2019, 1455: 196-205. PMID: 31074515, PMCID: PMC6834858, DOI: 10.1111/nyas.14098.Peer-Reviewed Original ResearchConceptsDepression-like behaviorAntidepressant efficacyTLQP-62VGF-derived peptide TLQP-62Stress-induced depression-like behaviorsBDNF-dependent mechanismAntidepressant-like effectsChronic variable stressGrape-derived polyphenolsAntidepressant actionAntidepressant effectsBDNF expressionNaive miceDorsal hippocampusPolyphenol preparationsFloxed miceVGF expressionPrior knockdownEfficacyVGFMiceMolecular mechanismsRecent studiesVariable stressBDNF
2018
VGF and its C-terminal peptide TLQP-62 in ventromedial prefrontal cortex regulate depression-related behaviors and the response to ketamine
Jiang C, Lin WJ, Labonté B, Tamminga CA, Turecki G, Nestler EJ, Russo SJ, Salton SR. VGF and its C-terminal peptide TLQP-62 in ventromedial prefrontal cortex regulate depression-related behaviors and the response to ketamine. Neuropsychopharmacology 2018, 44: 971-981. PMID: 30504797, PMCID: PMC6462025, DOI: 10.1038/s41386-018-0277-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntidepressive AgentsBehavior, AnimalBrain-Derived Neurotrophic FactorDepressionDepressive Disorder, MajorDisease Models, AnimalDisease SusceptibilityFemaleHumansKetamineMaleMiceMice, 129 StrainMice, Inbred C57BLMice, TransgenicNerve Growth FactorsNeuropeptidesPeptidesPrefrontal CortexStress, PsychologicalConceptsChronic restraint stressMajor depressive disorderAntidepressant efficacyAntidepressant responseVentromedial prefrontal cortexPrefrontal cortexAntidepressant drug treatmentKetamine's antidepressant efficacyAntidepressant-like effectsDepression-related behaviorsBrodmann area 25Neuropeptide precursor VGFChannel-mediated Ca2Underlying molecular pathwaysTLQP-62Vgf knockdownVGF levelsBDNF expressionMDD patientsRestraint stressDepressive disorderFunctional deficitsDrug treatmentBehavioral deficitsNucleus accumbens