2021
Antiseizure Medication Withdrawal in Seizure-Free Patients: Practice Advisory Update Summary
Gloss D, Pargeon K, Pack A, Varma J, French JA, Tolchin B, Dlugos DJ, Mikati MA, Harden C. Antiseizure Medication Withdrawal in Seizure-Free Patients: Practice Advisory Update Summary. Neurology 2021, 97: 1072-1081. PMID: 34873018, DOI: 10.1212/wnl.0000000000012944.Peer-Reviewed Original ResearchConceptsAntiseizure medicationsSeizure recurrenceSeizure freedomASM withdrawalPediatric patientsInsufficient evidenceAntiseizure medication withdrawalSeizure-free adultsSeizure-free patientsNeurology practice parameterSignificant differencesLong-term riskQuality of lifeMedication withdrawalStatus epilepticusEpilepsy surgeryPractice parametersRecurrencePatientsAmerican AcademyEpileptiform EEGMonthsWithdrawalAdultsRiskHow Should Clinicians Minimize Harms and Maximize Benefits When Diagnosing and Treating Disorders Without Biomarkers?
Tolchin B, Tolchin DW, Stein MA. How Should Clinicians Minimize Harms and Maximize Benefits When Diagnosing and Treating Disorders Without Biomarkers? The AMA Journal Of Ethic 2021, 23: e530-536. PMID: 34351262, DOI: 10.1001/amajethics.2021.530.Peer-Reviewed Original Research
2020
Neuropsychiatric Aspects of Epilepsy
Tolchin B, Hirsch LJ, LaFrance WC. Neuropsychiatric Aspects of Epilepsy. Psychiatric Clinics Of North America 2020, 43: 275-290. PMID: 32439022, DOI: 10.1016/j.psc.2020.02.002.Peer-Reviewed Original ResearchMeSH KeywordsAnxietyCognitive DysfunctionComorbidityDepressionEpilepsyHumansPsychotic DisordersQuality of LifeConceptsNeuropsychiatric disordersNeuropsychiatric aspectsCertain neuropsychiatric disordersAntiseizure medicationsClinical outcomesTherapeutic optionsEpidemiologic studiesEpilepsyMultidisciplinary teamNeuropsychiatric impactDisordersBidirectional relationshipTreatmentClose collaborationComorbiditiesMedicationsPathophysiologySocial factorsDiagnosis
2019
Randomized controlled trial of motivational interviewing for psychogenic nonepileptic seizures
Tolchin B, Baslet G, Suzuki J, Martino S, Blumenfeld H, Hirsch LJ, Altalib H, Dworetzky BA. Randomized controlled trial of motivational interviewing for psychogenic nonepileptic seizures. Epilepsia 2019, 60: 986-995. PMID: 30980679, DOI: 10.1111/epi.14728.Peer-Reviewed Original ResearchConceptsPsychogenic nonepileptic seizuresQuality of lifeMI participantsPNES frequencyMotivational interviewingControl participantsNonepileptic seizuresQuaternary care medical centerEmergency department visitsEmergency department utilizationSingle neurologistDepartment visitsTreatment adherenceControl armMedical CenterMI armsSeizuresVisitsTrialsAdherenceParticipantsPsychotherapyAdherentArmReferralAdherence with psychotherapy and treatment outcomes for psychogenic nonepileptic seizures.
Tolchin B, Dworetzky BA, Martino S, Blumenfeld H, Hirsch LJ, Baslet G. Adherence with psychotherapy and treatment outcomes for psychogenic nonepileptic seizures. Neurology 2019, 92: e675-e679. PMID: 30610097, PMCID: PMC6382361, DOI: 10.1212/wnl.0000000000006848.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAdult Survivors of Child AbuseAgedAged, 80 and overCohort StudiesConversion DisorderEmergency Service, HospitalEthnicityFemaleFollow-Up StudiesHumansMaleMiddle AgedMinority GroupsOdds RatioProspective StudiesPsychotherapyQuality of LifeSeizuresTreatment Adherence and ComplianceTreatment OutcomeYoung AdultConceptsPsychogenic nonepileptic seizuresQuality of lifePNES frequencyNonepileptic seizuresProspective cohort studyEmergency department utilizationTime of referralBaseline characteristicsCohort studyED visitsSeizure frequencyED utilizationPotential confoundersWomen's HospitalTreatment outcomesMedium effect sizeLocal therapistsMultivariate modelAdherenceChildhood abuseSeizuresHospitalSignificant reductionOutcomesEffect size