2019
Genomewide Gene-by-Sex Interaction Scans Identify ADGRV1 for Sex Differences in Opioid Dependent African Americans
Yang BZ, Zhou H, Cheng Z, Kranzler HR, Gelernter J. Genomewide Gene-by-Sex Interaction Scans Identify ADGRV1 for Sex Differences in Opioid Dependent African Americans. Scientific Reports 2019, 9: 18070. PMID: 31792237, PMCID: PMC6889277, DOI: 10.1038/s41598-019-53560-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultAllelesAnalgesics, OpioidBlack or African AmericanBrainCalcium-Binding ProteinsFemaleGene Expression ProfilingGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMiddle AgedOpioid-Related DisordersPolymorphism, Single NucleotideReceptors, G-Protein-CoupledReceptors, Kainic AcidSex FactorsWhite PeopleConceptsOpioid dependenceOD riskSex-different effectsSex differencesInferior olivary nucleusDSM-IV diagnosisDimorphic riskSubstantia nigraAA menOlivary nucleusFrontal cortexEuropean-American subjectsADGRV1Further studiesRiskAfrican AmericansGenetic variantsDisease enrichment analysisBrainSex interactionNominal significanceMenFirst studyPutamenLung
2018
GWAS and network analysis of co‐occurring nicotine and alcohol dependence identifies significantly associated alleles and network
Xiang B, Yang B, Zhou H, Kranzler H, Gelernter J. GWAS and network analysis of co‐occurring nicotine and alcohol dependence identifies significantly associated alleles and network. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2018, 180: 3-11. PMID: 30488612, PMCID: PMC6918694, DOI: 10.1002/ajmg.b.32692.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismAllelesBlack or African AmericanComorbidityEthanolFemaleG(M2) Activator ProteinGene FrequencyGene Regulatory NetworksGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMiddle AgedNicotinePolymorphism, Single NucleotideProtein Interaction MapsRisk FactorsTobacco Use DisorderWhite PeopleConceptsGene subnetworksProtein-protein interaction (PPI) network analysisGenome-wide significant variantsInteraction network analysisGene-set analysisFunctional enrichment analysisSignificant SNPsQuantitative lociNerve growth factor pathwayGene enrichmentEnrichment analysisNetwork analysisGenetic traitsGrowth factor pathwaysRisk genesSignificant variantsGenesStudy of AddictionSNPsFactor pathwayGM2AAmphetamine addictionGenetic riskGWASSubnetworks
2017
GRIK1 and GABRA2 Variants Have Distinct Effects on the Dose‐Related Subjective Response to Intravenous Alcohol in Healthy Social Drinkers
Yang B, Arias AJ, Feinn R, Krystal JH, Gelernter J, Petrakis IL. GRIK1 and GABRA2 Variants Have Distinct Effects on the Dose‐Related Subjective Response to Intravenous Alcohol in Healthy Social Drinkers. Alcohol Clinical And Experimental Research 2017, 41: 2025-2032. PMID: 29131352, PMCID: PMC5764175, DOI: 10.1111/acer.13516.Peer-Reviewed Original Research
2016
Sex‐specific linkage scans in opioid dependence
Yang B, Han S, Kranzler HR, Palmer AA, Gelernter J. Sex‐specific linkage scans in opioid dependence. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2016, 174: 261-268. PMID: 27762075, PMCID: PMC5695218, DOI: 10.1002/ajmg.b.32507.Peer-Reviewed Original ResearchAdultBlack or African AmericanBlack PeopleChromosome MappingCocaine-Related DisordersFemaleGenetic LinkageGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLod ScoreMaleMiddle AgedOpioid-Related DisordersPolymorphism, Single NucleotideRisk FactorsSex FactorsWhite People
2014
The α-endomannosidase gene (MANEA) is associated with panic disorder and social anxiety disorder
Jensen KP, Stein MB, Kranzler HR, Yang BZ, Farrer LA, Gelernter J. The α-endomannosidase gene (MANEA) is associated with panic disorder and social anxiety disorder. Translational Psychiatry 2014, 4: e353-e353. PMID: 24473444, PMCID: PMC3905232, DOI: 10.1038/tp.2013.122.Peer-Reviewed Original ResearchConceptsPanic disorderAnxiety disordersCocaine-induced paranoiaAnxiety disorder casesWhole blood cellsPsychiatric disorder riskWarrants further investigationAfrican American subjectsComorbid drugPD casesPsychiatric disordersAlcohol dependenceBrain tissueCocaine useBehavioral effectsBlood cellsClinical potentialGene variantsDisordersDisorder casesSingle nucleotide polymorphismsDisorder riskIndependent samplesPsychiatric phenotypesFurther investigation
2013
Distinct Loci in the CHRNA5/CHRNA3/CHRNB4 Gene Cluster Are Associated With Onset of Regular Smoking
Stephens SH, Hartz SM, Hoft NR, Saccone NL, Corley RC, Hewitt JK, Hopfer CJ, Breslau N, Coon H, Chen X, Ducci F, Dueker N, Franceschini N, Frank J, Han Y, Hansel NN, Jiang C, Korhonen T, Lind PA, Liu J, Lyytikäinen L, Michel M, Shaffer JR, Short SE, Sun J, Teumer A, Thompson JR, Vogelzangs N, Vink JM, Wenzlaff A, Wheeler W, Yang B, Aggen SH, Balmforth AJ, Baumeister SE, Beaty TH, Benjamin DJ, Bergen AW, Broms U, Cesarini D, Chatterjee N, Chen J, Cheng Y, Cichon S, Couper D, Cucca F, Dick D, Foroud T, Furberg H, Giegling I, Gillespie NA, Gu F, Hall AS, Hällfors J, Han S, Hartmann AM, Heikkilä K, Hickie IB, Hottenga JJ, Jousilahti P, Kaakinen M, Kähönen M, Koellinger PD, Kittner S, Konte B, Landi M, Laatikainen T, Leppert M, Levy SM, Mathias RA, McNeil DW, Medland SE, Montgomery GW, Murray T, Nauck M, North KE, Paré PD, Pergadia M, Ruczinski I, Salomaa V, Viikari J, Willemsen G, Barnes KC, Boerwinkle E, Boomsma DI, Caporaso N, Edenberg HJ, Francks C, Gelernter J, Grabe HJ, Hops H, Jarvelin M, Johannesson M, Kendler KS, Lehtimäki T, Magnusson PK, Marazita ML, Marchini J, Mitchell BD, Nöthen MM, Penninx BW, Raitakari O, Rietschel M, Rujescu D, Samani NJ, Schwartz AG, Shete S, Spitz M, Swan GE, Völzke H, Veijola J, Wei Q, Amos C, Cannon DS, Grucza R, Hatsukami D, Heath A, Johnson EO, Kaprio J, Madden P, Martin NG, Stevens VL, Weiss RB, Kraft P, Bierut LJ, Ehringer MA. Distinct Loci in the CHRNA5/CHRNA3/CHRNB4 Gene Cluster Are Associated With Onset of Regular Smoking. Genetic Epidemiology 2013, 37: 846-859. PMID: 24186853, PMCID: PMC3947535, DOI: 10.1002/gepi.21760.Peer-Reviewed Original ResearchConceptsGene clusterAssociation signalsEarly smoking behaviourSmoking behaviorCHRNA5/A3/B4 gene clusterNicotinic acetylcholine receptor genesRobust association signalsNeuronal nicotinic acetylcholine receptor geneAcetylcholine receptor genesNicotine dependenceCHRNB4 gene clusterSignificant associationB4 gene clusterDistinct lociLung cancer riskRegular tobacco useAssociation resultsNicotine dependence phenotypesDependence phenotypesReceptor geneCotinine levelsRs1948PhenotypeRegular smokingProtective effect
2012
GABRA2 Genotype, Impulsivity, and Body Mass
Bauer LO, Yang B, Houston RJ, Kranzler HR, Gelernter J. GABRA2 Genotype, Impulsivity, and Body Mass. American Journal On Addictions 2012, 21: 404-410. PMID: 22882390, PMCID: PMC3773931, DOI: 10.1111/j.1521-0391.2012.00252.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttention Deficit Disorder with HyperactivityBody Mass IndexCase-Control StudiesConnecticutFemaleGenotypeHumansImpulsive BehaviorMaleMiddle AgedPolymorphism, Single NucleotidePsychiatric Status Rating ScalesReceptors, GABA-ASex FactorsSubstance Abuse Treatment CentersSubstance-Related DisordersConceptsBody mass indexElevated body mass indexAssociation of BMIGABRA2 genotypeSubstance dependenceAttention-deficit/hyperactivity disorderHigh-calorie foodsPrevious pregnancyMass indexElectroencephalographic featuresRisk factorsChildhood symptomsScale scoreDrug abstinenceCalorie foodsHyperactivity disorderGenetic findingsWomenLonger durationBarratt Impulsiveness ScalePsychological indicatorsGABRA2 variantsSex differencesSecond analysisBody mass
2011
GABRG1 and GABRA2 Variation Associated with Alcohol Dependence in African Americans
Ittiwut C, Yang B, Kranzler HR, Anton RF, Hirunsatit R, Weiss RD, Covault J, Farrer LA, Gelernter J. GABRG1 and GABRA2 Variation Associated with Alcohol Dependence in African Americans. Alcohol Clinical And Experimental Research 2011, 36: 588-593. PMID: 21919924, PMCID: PMC3250564, DOI: 10.1111/j.1530-0277.2011.01637.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismBlack or African AmericanDNAFemaleGenetic VariationGenotypeHaplotypesHumansLinkage DisequilibriumMaleMiddle AgedPolymorphism, Single NucleotideReceptors, GABA-AAssociation of CHRNA4 polymorphisms with smoking behavior in two populations
Han S, Yang B, Kranzler HR, Oslin D, Anton R, Gelernter J. Association of CHRNA4 polymorphisms with smoking behavior in two populations. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2011, 156: 421-429. PMID: 21445957, PMCID: PMC3742073, DOI: 10.1002/ajmg.b.31177.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlack or African AmericanFemaleGenome-Wide Association StudyHumansLinkage DisequilibriumMaleMiddle AgedPolymorphism, Single NucleotideReceptors, NicotinicSmokingTobacco Use DisorderWhite PeopleConceptsSingle nucleotide polymorphismsVariation in NGFB is associated with primary affective disorders in women
Cui D, Zhang H, Yang B, Listman JB, Li D, Price LH, Carpenter LL, Tyrka AR, Anton RF, Kranzler HR, Gelernter J. Variation in NGFB is associated with primary affective disorders in women. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2011, 156: 401-412. PMID: 21294249, PMCID: PMC3108453, DOI: 10.1002/ajmg.b.31175.Peer-Reviewed Original Research
2007
Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case–control and family samples
Yang BZ, Kranzler HR, Zhao H, Gruen JR, Luo X, Gelernter J. Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case–control and family samples. Human Molecular Genetics 2007, 16: 2844-2853. PMID: 17761687, DOI: 10.1093/hmg/ddm240.Peer-Reviewed Original ResearchThe OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk
Zhang H, Kranzler HR, Yang BZ, Luo X, Gelernter J. The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk. Molecular Psychiatry 2007, 13: 531-543. PMID: 17622222, PMCID: PMC3163084, DOI: 10.1038/sj.mp.4002035.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAlcoholismCase-Control StudiesCocaine-Related DisordersEuropeExonsFemaleGenetic Predisposition to DiseaseHaplotypesHeroin DependenceHumansLinkage DisequilibriumMaleMiddle AgedPolymorphism, Single NucleotideReceptors, Opioid, deltaReceptors, Opioid, kappaRiskSubstance-Related DisordersUnited StatesConceptsLogistic regression analysisSingle nucleotide polymorphismsRegression analysisTag single nucleotide polymorphismsOPRD1 variantsG alleleC alleleDrug dependenceSignificant associationRisk effectsEuropean AmericansStratification artifactSignificant differencesPositive associationHaplotypic associationsMultiple testingAssociationOPRK1OPRD1Dependence riskSD
2006
Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence
Zhang H, Ozbay F, Lappalainen J, Kranzler HR, van Dyck CH, Charney DS, Price LH, Southwick S, Yang B, Rasmussen A, Gelernter J. Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2006, 141B: 387-393. PMID: 16649215, PMCID: PMC2567822, DOI: 10.1002/ajmg.b.30332.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAlzheimer DiseaseBrain-Derived Neurotrophic FactorChromatography, High Pressure LiquidDNA Mutational AnalysisFemaleGene FrequencyGenotypeHaplotypesHumansLinkage DisequilibriumLogistic ModelsMaleMiddle AgedMood DisordersPolymorphism, Single NucleotideSchizophreniaStress Disorders, Post-TraumaticSubstance-Related DisordersConceptsPosttraumatic stress disorderAffective disordersAlzheimer's diseaseSubstance dependenceGene variantsStress disorderBDNF gene variantsNormal control subjectsLogistic regression analysisAge of subjectsBDNF variantsNeurotrophic factorControl subjectsBDNF geneBDNF SNPsG genotypeEuropean-American subjectsG alleleDrug dependenceNeuropsychiatric disordersModest associationSchizophreniaDiseaseNovel gene variantsDisorders
2005
Tumour necrosis factor α polymorphism (−1031T/C) is associated with age of onset of schizophrenia
Zhang X, Haile C, Tan Y, Zuo L, Yang B, Cao L, Zhou D. Tumour necrosis factor α polymorphism (−1031T/C) is associated with age of onset of schizophrenia. Molecular Psychiatry 2005, 10: 897-899. PMID: 16027740, DOI: 10.1038/sj.mp.4001710.Peer-Reviewed Original ResearchAge of OnsetFemaleHumansMaleMiddle AgedPolymorphism, Single NucleotideSchizophreniaTumor Necrosis Factor-alpha