Enhancing human capillary tube network assembly and maturation through upregulated expression of pericyte-derived TIMP-3
Yrigoin K, Bernard K, Castaño M, Cleaver O, Sumanas S, Davis G. Enhancing human capillary tube network assembly and maturation through upregulated expression of pericyte-derived TIMP-3. Frontiers In Cell And Developmental Biology 2024, 12: 1465806. DOI: 10.3389/fcell.2024.1465806.Peer-Reviewed Original ResearchTIMP-3Endothelial cellsHuman pericytesPresence of doxycyclineCollagen type IVCo-culture modelIncreasing tube lengthHuman endothelial cellsStabilization networkTissue inhibitorNetwork assemblyPericyte recruitmentCapillary assemblyCo-assemblyType IVUpregulated expressionPericytesCo-cultureTube lengthDoxycycline additionEC-pericyte interactionsTube widthDoxycyclineNetwork of capillary tubes