2024
Heightened response to positive facial cues as a potential marker of resilience following childhood adversity
Gerin M, Viding E, Neil L, Armbruster-Genc D, Freeman Z, Sharp M, Phillips H, McCrory E. Heightened response to positive facial cues as a potential marker of resilience following childhood adversity. European Journal Of Psychotraumatology 2024, 15: 2309783. PMID: 38318813, PMCID: PMC10849006, DOI: 10.1080/20008066.2024.2309783.Peer-Reviewed Original ResearchConceptsFacial cuesMaltreatment experiencesPresence of social supportSocial supportLow symptomsAssociated with lower symptomsThreat-related cuesPositive social cuesIncreased psychiatric riskPerceived emotional intensityMarkers of resilienceChildhood maltreatment experiencesNo group differencesMental health symptomsLevels of social supportPerceived social supportAssociated with better mental healthMental health vulnerabilitiesMental health outcomesBetter mental healthExperiences of abusePerceived intensityHappy facesChildhood maltreatmentImplicit processesAtypical Interpersonal Problem-Solving and Resting-state Functional Connectivity in Adolescents with Maltreatment Experience
Gerin M, Viding E, Puetz V, Armbruster-Genc D, Rankin G, McCrory E. Atypical Interpersonal Problem-Solving and Resting-state Functional Connectivity in Adolescents with Maltreatment Experience. Current Neuropharmacology 2024, 22: 290-301. PMID: 37818587, PMCID: PMC10788892, DOI: 10.2174/1570159x22666231002145440.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityPosterior cingulate cortexMedial prefrontal cortexMental health symptomsMaltreatment experiencesSocial functioningLingual gyrusFunctional connectivityHealth symptomsInterpersonal problem-solving skillsRetrosplenial cortexElevated mental health symptomsDefault mode network hubInterpersonal problem solvingPoor social functioningAdverse environmental experiencesProblem-solving performanceNon-maltreated peersProblem-solving skillsExperiences of abuseSeed-based analysisNeurocognitive processingNeurocognitive functioningMental health disordersEarly adversity
2023
A systematic review of childhood maltreatment and resting state functional connectivity
Gerin M, Viding E, Herringa R, Russell J, McCrory E. A systematic review of childhood maltreatment and resting state functional connectivity. Developmental Cognitive Neuroscience 2023, 64: 101322. PMID: 37952287, PMCID: PMC10665826, DOI: 10.1016/j.dcn.2023.101322.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmygdalaBrainBrain MappingChildChild AbuseGyrus CinguliHumansMagnetic Resonance ImagingConceptsResting-state functional connectivityAnterior cingulate cortexFunctional connectivityCingulate cortexChildhood maltreatmentAltered functional connectivityState functional connectivityDorsal anterior cingulate cortexNegative psychiatric outcomesVentral anterior cingulate cortexDorsolateral prefrontal cortexRsFC alterationsAltered connectivityInclusion criteriaAmygdala connectivityNineteen studiesPsychiatric outcomesFuture symptomsSystematic reviewBrain regionsClinical disordersBrain circuitsAnterior insulaPrefrontal cortexMaltreatment exposure
2022
Altered reward and effort processing in children with maltreatment experience: a potential indicator of mental health vulnerability
Armbruster-Genç D, Valton V, Neil L, Vuong V, Freeman Z, Packer K, Kiffin M, Roiser J, Viding E, McCrory E. Altered reward and effort processing in children with maltreatment experience: a potential indicator of mental health vulnerability. Neuropsychopharmacology 2022, 47: 1063-1070. PMID: 35149765, PMCID: PMC8832084, DOI: 10.1038/s41386-022-01284-7.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingInternalizing symptomsHistory of maltreatmentAnterior cingulate cortexEffort processingEffort-based decision-making taskDecision-making taskEffort-based decisionElevated internalizing symptomsNon-maltreated childrenImpact of maltreatmentMental health vulnerabilitiesFuture internalizing symptomsNeural indicesACC activationAltered rewardBehavioral indicesMaltreatment experiencesLatent vulnerabilityCingulate cortexEffort sensitivityGroup differencesRewardMaltreatmentLongitudinal study
2021
Functional brain plasticity following childhood maltreatment: A longitudinal fMRI investigation of autobiographical memory processing.
Puetz V, Viding E, Maguire E, Mechelli A, Armbruster-Genç D, Sharp M, Rankin G, Gerin M, McCrory E. Functional brain plasticity following childhood maltreatment: A longitudinal fMRI investigation of autobiographical memory processing. Development And Psychopathology 2021, 35: 1382-1389. PMID: 34924093, DOI: 10.1017/s0954579421001292.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrainChildHumansMagnetic Resonance ImagingMemory, EpisodicMental RecallNeuronal PlasticityConceptsChildhood maltreatmentAutobiographical memory processingCortical midline structuresValenced cue wordsPotential developmental plasticityCue wordsMemory processingFMRI studyBOLD signal changesNeural functioningPsychological assessmentBrain networksMaltreatmentMidline structuresMaturational changesLongitudinal analysisProcessingSignal changesFMRIPsychopathologyRecallAdolescentsFunctioningWordsDevelopmental plasticityTrust and childhood maltreatment: evidence of bias in appraisal of unfamiliar faces
Neil L, Viding E, Armbruster‐Genc D, Lisi M, Mareschal I, Rankin G, Sharp M, Phillips H, Rapley J, Martin P, McCrory E. Trust and childhood maltreatment: evidence of bias in appraisal of unfamiliar faces. Journal Of Child Psychology And Psychiatry 2021, 63: 655-662. PMID: 34500497, DOI: 10.1111/jcpp.13503.Peer-Reviewed Original ResearchConceptsTrust processingUnfamiliar facesChildhood maltreatmentPoor social functioningMental health difficultiesMental health problemsFacial stimuliCognitive abilitiesTrust judgmentsTrust attributionTrustworthiness dimensionsCommunity-based sampleSocial service recordsSocial functioningMaltreatment experiencesHealth difficultiesChild maltreatmentMaltreatmentSocial bondsAtypical patternsPeersEvidence of biasChildrenSocioeconomic statusProcessingModulation of Amygdala Response by Cognitive Conflict in Adolescents with Conduct Problems and Varying Levels of CU Traits
Sebastian C, Stafford J, McCrory E, Sethi A, De Brito S, Lockwood P, Viding E. Modulation of Amygdala Response by Cognitive Conflict in Adolescents with Conduct Problems and Varying Levels of CU Traits. Research On Child And Adolescent Psychopathology 2021, 49: 1043-1054. PMID: 33728508, PMCID: PMC8222043, DOI: 10.1007/s10802-021-00787-z.Peer-Reviewed Original ResearchConceptsCallous-unemotional traitsNegative emotional stimuliAmygdala responseConduct problemsEmotional stimuliCognitive conflictTask demandsCognitive task demandsCognitive conflict tasksLow callous-unemotional traitsCP/HCUHealthy adult sampleCognitive controlEmotional facesReactive aggressionAtypical modulationConflict taskNeurocognitive responsesAffect regulationCU traitsPotential translational relevanceConflict conditionsPrefrontal areasHigh conflictAdult samples
2020
Individual differences in sensitivity to the early environment as a function of amygdala and hippocampus volumes: An exploratory analysis in 12-year-old boys
Pluess M, De Brito S, Bartoli A, McCrory E, Viding E. Individual differences in sensitivity to the early environment as a function of amygdala and hippocampus volumes: An exploratory analysis in 12-year-old boys. Development And Psychopathology 2020, 34: 901-910. PMID: 33342453, DOI: 10.1017/s0954579420001698.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmygdalaBrainChildHippocampusHumansIndividualityMagnetic Resonance ImagingMaleConceptsIndividual differencesLeft amygdalaEnvironmental influencesLeft amygdala volumeNeurobiological sensitivityImportant brain regionsChild behaviorBrain regionsEarly environmentContextual factorsPositive experiencesBrain structuresAmygdala volumePreliminary evidenceAmygdalaGeneral environmental qualityHippocampus volumeExploratory analysisBoysExploratory studyEnvironmental featuresThinking about Others’ Minds: Mental State Inference in Boys with Conduct Problems and Callous-Unemotional Traits
Roberts R, McCrory E, Bird G, Sharp M, Roberts L, Viding E. Thinking about Others’ Minds: Mental State Inference in Boys with Conduct Problems and Callous-Unemotional Traits. Research On Child And Adolescent Psychopathology 2020, 48: 1279-1290. PMID: 32632744, PMCID: PMC7445196, DOI: 10.1007/s10802-020-00664-1.Peer-Reviewed Original ResearchConceptsMental state inferencesSocial judgment taskConduct problemsState inferenceMental statesCP/HCUCallous-unemotional traitsMind-related commentsSocial cognitionJudgment taskIntact abilityAntisocial actionsUnemotional TraitsPeople's thoughtsDifferent mindsGroup differencesMore difficultyBest friendTaskMindBoysNew measureDifferent aspectsThoughtCognitionAutobiographical memory as a latent vulnerability mechanism following childhood maltreatment: Association with future depression symptoms and prosocial behavior
Puetz V, Viding E, Hoffmann F, Gerin M, Sharp M, Rankin G, Maguire E, Mechelli A, McCrory E. Autobiographical memory as a latent vulnerability mechanism following childhood maltreatment: Association with future depression symptoms and prosocial behavior. Development And Psychopathology 2020, 33: 1300-1307. PMID: 32573399, DOI: 10.1017/s0954579420000504.Peer-Reviewed Original ResearchConceptsOvergeneral memoryProsocial behaviorChildhood maltreatmentAutobiographical memory recallAutobiographical Memory TestSocio-emotional functioningPsycho-social functioningValenced cue wordsPoor social functioningSample of adolescentsFuture depression symptomsDepressive symptomsChildhood maltreatment historyTrend-level associationCognitive mechanismsCue wordsNeural reactivityAutobiographical memoryMemory testMemory recallVulnerability mechanismsBrain activitySocial functioningElevated depressive symptomsMaltreatment history
2019
Ghosts in the Nursery: An Experimental Investigation of a Parent’s Own Maltreatment Experience, Attention to Infant Faces, and Dyadic Reciprocity
Thompson-Booth C, Viding E, Puetz VB, Rutherford HJV, Mayes LC, McCrory EJ. Ghosts in the Nursery: An Experimental Investigation of a Parent’s Own Maltreatment Experience, Attention to Infant Faces, and Dyadic Reciprocity. Emotion 2019, 19: 1093-1102. PMID: 30234333, DOI: 10.1037/emo0000464.Peer-Reviewed Original ResearchConceptsInfant facesChildhood maltreatmentAttentional processingDyadic reciprocityLower attentional biasVisual search taskAttentional biasEmotional cuesCognitive processingPreferential processingInfant affectParenting behaviorsInfant cuesSearch taskAn Experimental InvestigationCommunity sampleMaltreatment experiencesMaltreatmentPreferential biasOwn childrenCuesExploratory analysisProcessingFaceImportant implicationsMulti–Polygenic Score Approach to Identifying Individual Vulnerabilities Associated With the Risk of Exposure to Bullying
Schoeler T, Choi S, Dudbridge F, Baldwin J, Duncan L, Cecil C, Walton E, Viding E, McCrory E, Pingault J. Multi–Polygenic Score Approach to Identifying Individual Vulnerabilities Associated With the Risk of Exposure to Bullying. JAMA Psychiatry 2019, 76: 730-738. PMID: 30942833, PMCID: PMC6583782, DOI: 10.1001/jamapsychiatry.2019.0310.Peer-Reviewed Original ResearchConceptsMental health vulnerabilitiesMAIN OUTCOMEPopulation-based birth cohort studyHealth vulnerabilityIndividual vulnerabilityBody mass indexBirth cohort studyDiagnosis of depressionYears of ageDate of deliveryAttention-deficit/hyperactivity disorderAvon Longitudinal StudyMental health problemsPolygenic score approachLast followCohort studyMass indexMultivariable analysisRisk of exposureAssessment of exposureRisk factorsPrevention strategiesHealth problemsSignificant associationALSPAC dataInvestigating patterns of neural response associated with childhood abuse v. childhood neglect
Puetz V, Viding E, Gerin M, Pingault J, Sethi A, Knodt A, Radtke S, Brigidi B, Hariri A, McCrory E. Investigating patterns of neural response associated with childhood abuse v. childhood neglect. Psychological Medicine 2019, 50: 1398-1407. PMID: 31190662, DOI: 10.1017/s003329171900134x.Peer-Reviewed Original ResearchConceptsNeural reactivityThreat reactivityMaltreatment experiencesChildhood abuseChildhood maltreatmentHigher-order cortical regionsFronto-parietal networkEffects of abuseChildhood abuse experiencesExperiences of neglectPoor mental health outcomesEffects of neglectChildhood maltreatment experiencesMental health outcomesExperiences of abuseCognitive processingBrain imaging analysisFacial cuesNeural responsesNeglect experiencesDifferential effectsAbuse experiencesChildhood neglectDorsal amygdalaVentral amygdalaHeightened amygdala reactivity and increased stress generation predict internalizing symptoms in adults following childhood maltreatment
Gerin M, Viding E, Pingault J, Puetz V, Knodt A, Radtke S, Brigidi B, Swartz J, Hariri A, McCrory E. Heightened amygdala reactivity and increased stress generation predict internalizing symptoms in adults following childhood maltreatment. Journal Of Child Psychology And Psychiatry 2019, 60: 752-761. PMID: 30933355, PMCID: PMC6594878, DOI: 10.1111/jcpp.13041.Peer-Reviewed Original ResearchConceptsMajor stressful life eventsStressful life eventsAmygdala reactivityChildhood maltreatmentLife eventsInternalizing disordersBaseline internalizing symptomsInternalizing symptomsHistory of maltreatmentThreat-related amygdala reactivityDevelopmental insultsPsychiatric riskPropensity scoreSymptomsFuture internalizing symptomsStress exposureMental healthYoung adultsSeverity 1Socioeconomic statusFuture psychopathologyPotent predictorSuch alterationsNonmaltreated peersMaltreatment statusEvidence of concurrent and prospective associations between early maltreatment and ADHD through childhood and adolescence
González R, Vélez-Pastrana M, McCrory E, Kallis C, Aguila J, Canino G, Bird H. Evidence of concurrent and prospective associations between early maltreatment and ADHD through childhood and adolescence. Social Psychiatry And Psychiatric Epidemiology 2019, 54: 671-682. PMID: 30903235, DOI: 10.1007/s00127-019-01659-0.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderADHD diagnosisEarly maltreatmentFoster placementPhysical abuseADHD medication statusRole of maltreatmentLongitudinal studyProspective associationsLikelihood of ADHDPuerto Rican backgroundHyperactivity disorderChildren-IVBoricua Youth StudyParental psychopathologyFamily environmentMaltreatment experiencesEmotional abuseMaltreatment exposureRisk of ADHDSexual abuseDisorder persistenceChildhood maltreatmentDiagnostic Interview ScheduleInitial evidenceNeurocognitive Adaptation and Mental Health Vulnerability Following Maltreatment: The Role of Social Functioning
McCrory E, Ogle J, Gerin M, Viding E. Neurocognitive Adaptation and Mental Health Vulnerability Following Maltreatment: The Role of Social Functioning. Child Maltreatment 2019, 24: 435-451. PMID: 30897955, DOI: 10.1177/1077559519830524.Peer-Reviewed Original ResearchConceptsSocial functioningEarly maltreatment experiencesMental health vulnerabilitiesMental health problemsNeurocognitive adaptationsEmotion regulationThreat processingStudy of childrenReward processingComputational psychiatryMental health disordersMaltreatment experiencesLatent vulnerabilityChildhood maltreatmentSocial supportFunctioningHealth disordersNeural functionMaltreatmentHealth vulnerabilityProcessingHealth problemsVulnerabilityKey findingsAdolescentsFacial emotion recognition during pregnancy: Examining the effects of facial age and affect
Byrne SP, Mayo A, O’Hair C, Zankman M, Austin GM, Thompson-Booth C, McCrory EJ, Mayes LC, Rutherford HJV. Facial emotion recognition during pregnancy: Examining the effects of facial age and affect. Infant Behavior And Development 2019, 54: 108-113. PMID: 30659998, DOI: 10.1016/j.infbeh.2018.09.008.Peer-Reviewed Original ResearchConceptsFacial expressionsFacial ageFacial emotion recognitionChildren's facial expressionsNeutral infantSad facesFacial affectAdult facesSad expressionsInfant facesEmotion recognitionPositive affectContext of evidenceFace typeFacial featuresFast recognitionAffectParticipantsFacePrior exposureNew mothersCuesRecognitionWeeks' gestationPregnancy women
2018
DRD4 methylation as a potential biomarker for physical aggression: An epigenome‐wide, cross‐tissue investigation
Cecil C, Walton E, Pingault J, Provençal N, Pappa I, Vitaro F, Côté S, Szyf M, Tremblay R, Tiemeier H, Viding E, McCrory E. DRD4 methylation as a potential biomarker for physical aggression: An epigenome‐wide, cross‐tissue investigation. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2018, 177: 746-764. PMID: 30411855, DOI: 10.1002/ajmg.b.32689.Peer-Reviewed Original ResearchEvidence for Depressogenic Spontaneous Thoughts and Altered Resting-State Connectivity in Adolescents With a Maltreatment History
Hoffmann F, Viding E, Puetz V, Gerin M, Sethi A, Rankin G, McCrory E. Evidence for Depressogenic Spontaneous Thoughts and Altered Resting-State Connectivity in Adolescents With a Maltreatment History. Journal Of The American Academy Of Child & Adolescent Psychiatry 2018, 57: 687-695.e4. PMID: 30196872, DOI: 10.1016/j.jaac.2018.05.020.Peer-Reviewed Original ResearchAn fMRI investigation of empathic processing in boys with conduct problems and varying levels of callous-unemotional traits
Sethi A, O'Nions E, McCrory E, Bird G, Viding E. An fMRI investigation of empathic processing in boys with conduct problems and varying levels of callous-unemotional traits. NeuroImage Clinical 2018, 18: 298-304. PMID: 29876250, PMCID: PMC5987797, DOI: 10.1016/j.nicl.2018.01.027.Peer-Reviewed Original ResearchConceptsCP/HCUMedial prefrontal cortexCallous-unemotional traitsConduct problemsOwn emotionsAnterior cingulate cortexAnterior insulaEmpathic processingAffective experienceConjunction analysisACC/medial prefrontal cortexBrain areasBayes factor analysisEmpathy deficitsFMRI investigationTD groupNeural responsesConjunction effectOne's feelingsLess empathyEmotionsPrefrontal cortexNeutral scenarioCingulate cortexOccipital cortex