Friedreich's Ataxia (GAA)n•(TTC)n Repeats Strongly Stimulate Mitotic Crossovers in Saccharomyces cerevisae
Tang W, Dominska M, Greenwell PW, Harvanek Z, Lobachev KS, Kim HM, Narayanan V, Mirkin SM, Petes TD. Friedreich's Ataxia (GAA)n•(TTC)n Repeats Strongly Stimulate Mitotic Crossovers in Saccharomyces cerevisae. PLOS Genetics 2011, 7: e1001270. PMID: 21249181, PMCID: PMC3020933, DOI: 10.1371/journal.pgen.1001270.Peer-Reviewed Original ResearchMeSH KeywordsChromosomes, FungalDNA Breaks, Double-StrandedDNA ReplicationGene ConversionMitosisSaccharomyces cerevisiaeTrinucleotide RepeatsConceptsDouble-strand breaksMitotic crossoversNon-reciprocal transferExpansions of trinucleotideFriedreich's ataxiaGenome instabilityMeiotic recombinationUnreplicated chromosomesDNA sequencesRecombination eventsCell cycleSaccharomyces cerevisaeYeastMajor classesChromosomesPotent sourceRepeatsHeterozygosityTrinucleotideCerevisaeRecombinationSequence