2024
Gene trajectory inference for single-cell data by optimal transport metrics
Qu R, Cheng X, Sefik E, Stanley III J, Landa B, Strino F, Platt S, Garritano J, Odell I, Coifman R, Flavell R, Myung P, Kluger Y. Gene trajectory inference for single-cell data by optimal transport metrics. Nature Biotechnology 2024, 1-11. PMID: 38580861, PMCID: PMC11452571, DOI: 10.1038/s41587-024-02186-3.Peer-Reviewed Original ResearchGene dynamicsGene programTrajectory inferenceBiological processesCell-cell graphDynamics of genesCell trajectory inferenceSingle-cell RNA sequencingSingle-cell dataCell state transitionsMyeloid lineage maturationDynamics of biological processesGene distributionRNA sequencingPseudotemporal orderingGene processingTrajectories of cellsGenesActivity of biological processesTechnical noiseGroups of cellsLineage maturationCellsConstruct cellsSequence
2000
Structural proteomics of an archaeon
Christendat D, Yee A, Dharamsi A, Kluger Y, Savchenko A, Cort J, Booth V, Mackereth C, Saridakis V, Ekiel I, Kozlov G, Maxwell K, Wu N, McIntosh L, Gehring K, Kennedy M, Davidson A, Pai E, Gerstein M, Edwards A, Arrowsmith C. Structural proteomics of an archaeon. Nature Structural & Molecular Biology 2000, 7: 903-909. PMID: 11017201, DOI: 10.1038/82823.Peer-Reviewed Original ResearchConceptsStructural proteomicsHigh-throughput strategyFunctional genomicsNonmembrane proteinsPutative functionsBiochemical functionsSequence analysisMethanobacterium thermoautotrophicumProtein propertiesThroughput strategyX-ray crystallographicBiochemical methodsProteomicsStructural studiesCentral roleProteinStructural targetsNMR spectroscopic analysisProteomeArchaeonGenomicsThermoautotrophicumSequenceFunctionSpectroscopic analysis