2005
Period3 Structural Variation: A Circadian Biomarker Associated with Breast Cancer in Young Women
Zhu Y, Brown HN, Zhang Y, Stevens RG, Zheng T. Period3 Structural Variation: A Circadian Biomarker Associated with Breast Cancer in Young Women. Cancer Epidemiology Biomarkers & Prevention 2005, 14: 268-270. PMID: 15668506, DOI: 10.1158/1055-9965.268.14.1.Peer-Reviewed Original ResearchConceptsCircadian genesCell cycle regulationCycle regulationCircadian biologyBiological pathwaysGenesHuman cancersCell proliferationLength variationTumor developmentStructural variationsCircadian rhythmNovel panelNovel findingsBreast cancerCircadian disruptionPotential biomarkersBiologyMutationsCaucasian controlsApoptosisBiomarkers AssociatedPathwayRegulationDeregulation
2004
Methyl‐CpG‐binding domain 2
Zhu Y, Spitz M, Zhang H, Grossman H, Frazier M, Wu X. Methyl‐CpG‐binding domain 2. Cancer 2004, 100: 1853-1858. PMID: 15112265, DOI: 10.1002/cncr.20199.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceCase-Control StudiesDNA MethylationDNA-Binding ProteinsFemaleGene Expression Regulation, NeoplasticGenetic Predisposition to DiseaseHumansLogistic ModelsMaleMolecular Sequence DataOdds RatioProbabilityPrognosisPromoter Regions, GeneticReference ValuesReverse Transcriptase Polymerase Chain ReactionRisk FactorsRNA, MessengerSensitivity and SpecificityUrinary Bladder NeoplasmsConceptsMBD2 expressionCarcinoma riskCurrent case-control studyReverse transcription polymerase chain reaction assaysCase-control studyPeripheral blood lymphocytesQuantitative reverse transcription-polymerase chain reaction assaysTranscription-polymerase chain reaction assaysMessenger RNA expressionReal-time quantitative reverse transcription-polymerase chain reaction assaysControl patientsLight smokersCase patientsHeavy smokersUnderlying molecular mechanismsTumor tissue typesBlood lymphocytesChain reaction assaysProtective effectProtective roleQuartile distributionDomain 2 proteinOlder individualsTumor developmentYoung individuals