2013
Forward genetics defines Xylt1 as a key, conserved regulator of early chondrocyte maturation and skeletal length
Mis EK, Liem KF, Kong Y, Schwartz NB, Domowicz M, Weatherbee SD. Forward genetics defines Xylt1 as a key, conserved regulator of early chondrocyte maturation and skeletal length. Developmental Biology 2013, 385: 67-82. PMID: 24161523, PMCID: PMC3895954, DOI: 10.1016/j.ydbio.2013.10.014.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBone and BonesCell DifferentiationCell ProliferationChondrocytesDwarfismFibroblast Growth FactorsHedgehog ProteinsMiceMice, Inbred C57BLMice, TransgenicMutation, MissenseOsteogenesisParathyroid Hormone-Related ProteinPentosyltransferasesSequence Analysis, DNASignal TransductionConceptsChondrocyte maturationCartilage templateN-ethyl-N-nitrosourea (ENU) mutagenesis screenSkeletal precursor cellsWild-type embryosHigh-throughput sequencingHuman birth defectsProteoglycan core proteinMutagenesis screenSequence captureVertebrate bodySubcellular localizationProteoglycan functionCoordinated processMouse mutantsMutantsAbnormal bone developmentMissense mutationsCore proteinBone developmentSkeletal elementsPrecursor cellsDwarfismMaturationGAG chainsForward genetics identifies Kdf1/1810019J16Rik as an essential regulator of the proliferation–differentiation decision in epidermal progenitor cells
Lee S, Kong Y, Weatherbee SD. Forward genetics identifies Kdf1/1810019J16Rik as an essential regulator of the proliferation–differentiation decision in epidermal progenitor cells. Developmental Biology 2013, 383: 201-213. PMID: 24075906, PMCID: PMC3841015, DOI: 10.1016/j.ydbio.2013.09.022.Peer-Reviewed Original ResearchMeSH Keywords14-3-3 ProteinsAllelesAnimalsBase SequenceCell DifferentiationCell ProliferationCleft PalateEmbryo LossEpidermisFemaleGene Expression Regulation, DevelopmentalGenes, RecessiveGenetic Complementation TestHeterozygoteKeratinocytesMaleMiceMice, Inbred C57BLMolecular Sequence DataPhenotypePhosphoproteinsPoint MutationProtein BindingProteinsRNA SplicingStem CellsTrans-ActivatorsConceptsEpidermal progenitor cellsEssential regulatorProgenitor cellsProliferation-differentiation balanceUnbiased genetic screenCell fate decisionsProliferation-differentiation decisionsCell proliferationUncontrolled cell proliferationFactor 1 geneProgenitor cell proliferationGenetic screenFate decisionsRepressive signalsTerminal fateInductive signalsPremature differentiationGenetic mechanismsInhibition of p63Terminal differentiationCell differentiationEpidermal cellsKDF1Rapid turnoverRate of proliferationAlleles of a Polymorphic ETV6 Binding Site in DCDC2 Confer Risk of Reading and Language Impairment
Powers NR, Eicher JD, Butter F, Kong Y, Miller LL, Ring SM, Mann M, Gruen JR. Alleles of a Polymorphic ETV6 Binding Site in DCDC2 Confer Risk of Reading and Language Impairment. American Journal Of Human Genetics 2013, 93: 19-28. PMID: 23746548, PMCID: PMC3710765, DOI: 10.1016/j.ajhg.2013.05.008.Peer-Reviewed Original ResearchMeSH KeywordsAllelesBase SequenceBinding SitesCase-Control StudiesDyslexiaGenetic Association StudiesHaplotypesHeLa CellsHumansLanguage Development DisordersLanguage TestsLinkage DisequilibriumMicrosatellite RepeatsMicrotubule-Associated ProteinsMolecular Sequence DataPhylogenyPolymorphism, GeneticPromoter Regions, GeneticProtein BindingProto-Oncogene Proteins c-etsRepressor ProteinsRisk Factors
2012
Exon capture and bulk segregant analysis: rapid discovery of causative mutations using high-throughput sequencing
del Viso F, Bhattacharya D, Kong Y, Gilchrist MJ, Khokha MK. Exon capture and bulk segregant analysis: rapid discovery of causative mutations using high-throughput sequencing. BMC Genomics 2012, 13: 649. PMID: 23171430, PMCID: PMC3526394, DOI: 10.1186/1471-2164-13-649.Peer-Reviewed Original ResearchConceptsBulk segregant analysisForward genetic screenSegregant analysisGenetic screenGenome assemblyExon captureCausative mutationsVertebrate model systemHigh-throughput sequencingHuman genetic analysisThousands of SNPsAssembly of scaffoldsModel systemGenomic resourcesVertebrate modelXenopus tropicalisFine mappingGenetic analysisCapture sequencingSequence variantsSequencingMutationsRapid discoveryMutantsExome sequencing
2009
Statistical Distributions of Sequencing by Synthesis with Probabilistic Nucleotide Incorporation
Kong Y. Statistical Distributions of Sequencing by Synthesis with Probabilistic Nucleotide Incorporation. Journal Of Computational Biology 2009, 16: 817-827. PMID: 19522665, DOI: 10.1089/cmb.2008.0215.Peer-Reviewed Original ResearchMeSH KeywordsBase PairingBase SequenceNucleotidesProbabilitySequence Analysis, DNAStatistical DistributionsCalculating complexity of large randomized libraries
Kong Y. Calculating complexity of large randomized libraries. Journal Of Theoretical Biology 2009, 259: 641-645. PMID: 19376134, DOI: 10.1016/j.jtbi.2009.04.008.Peer-Reviewed Original ResearchStatistical Distributions of Pyrosequencing
Kong Y. Statistical Distributions of Pyrosequencing. Journal Of Computational Biology 2009, 16: 31-42. PMID: 19072582, DOI: 10.1089/cmb.2008.0106.Peer-Reviewed Original Research