2021
Ketogenic Diets Induced Glucose Intolerance and Lipid Accumulation in Mice with Alterations in Gut Microbiota and Metabolites
Li Y, Yang X, Zhang J, Jiang T, Zhang Z, Wang Z, Gong M, Zhao L, Zhang C. Ketogenic Diets Induced Glucose Intolerance and Lipid Accumulation in Mice with Alterations in Gut Microbiota and Metabolites. MBio 2021, 12: 10.1128/mbio.03601-20. PMID: 33785628, PMCID: PMC8092315, DOI: 10.1128/mbio.03601-20.Peer-Reviewed Original ResearchConceptsKetogenic dietGut microbiotaProportion of fatLipid metabolismGlucose intoleranceInsulin resistanceFat accumulationMouse trialsNeurodegenerative diseasesLipid accumulationMore fat accumulationInduced glucose intoleranceLipid metabolism disordersAffected lipid metabolismMetabolism disordersMetabolic disordersGlucose homeostasisGlucose metabolismSource of fatHuman studiesHigh fatTreatment of diseasesMiceBeneficial effectsWeight lossThe effect of calorie intake, fasting, and dietary composition on metabolic health and gut microbiota in mice
Zhang Z, Chen X, Loh Y, Yang X, Zhang C. The effect of calorie intake, fasting, and dietary composition on metabolic health and gut microbiota in mice. BMC Biology 2021, 19: 51. PMID: 33740961, PMCID: PMC7977615, DOI: 10.1186/s12915-021-00987-5.Peer-Reviewed Original ResearchConceptsHigh-fat dietAd libitum groupMetabolic healthGut microbiotaIntermittent fastingNormal chow miceTotal energy intakeGut microbiota modulationDietary structureIF regimenMetabolic ameliorationNormal chowCR regimenMicrobiota modulationFood intakeDietary regimensCalorie intakeCR groupCR miceRegimenControl groupEnergy intakeGut microbial communityLipid metabolismFasting-refeeding cycle
2020
Lactobacillus Mucosae Strain Promoted by a High-Fiber Diet in Genetic Obese Child Alleviates Lipid Metabolism and Modifies Gut Microbiota in ApoE-/- Mice on a Western Diet
Jiang T, Wu H, Yang X, Li Y, Zhang Z, Chen F, Zhao L, Zhang C. Lactobacillus Mucosae Strain Promoted by a High-Fiber Diet in Genetic Obese Child Alleviates Lipid Metabolism and Modifies Gut Microbiota in ApoE-/- Mice on a Western Diet. Microorganisms 2020, 8: 1225. PMID: 32806628, PMCID: PMC7464838, DOI: 10.3390/microorganisms8081225.Peer-Reviewed Original ResearchWestern dietHigh-fiber dietGut microbiotaApoE-/- miceModifies gut microbiotaTreatment of hyperlipidemiaSevere lipid accumulationGut microbiota structureProbiotic candidate strainSupplementation of probioticsNext-generation probioticsMetabolic endotoxemiaAortic sinusHuman-derived strainsHyperlipidemiaTherapeutic methodsLipid metabolismAtherosclerosisLipid accumulationMiceSelection of candidatesApoEMicrobiota structureDietProbiotics
2018
Genetically Obese Human Gut Microbiota Induces Liver Steatosis in Germ-Free Mice Fed on Normal Diet
Wang R, Li H, Yang X, Xue X, Deng L, Shen J, Zhang M, Zhao L, Zhang C. Genetically Obese Human Gut Microbiota Induces Liver Steatosis in Germ-Free Mice Fed on Normal Diet. Frontiers In Microbiology 2018, 9: 1602. PMID: 30079055, PMCID: PMC6062601, DOI: 10.3389/fmicb.2018.01602.Peer-Reviewed Original ResearchHepatic transcriptional profilePreM groupGut microbiotaLiver steatosisNon-alcoholic fatty liver diseaseDietary weight loss programObesity-associated gut microbiotaLipid metabolismPeroxisome proliferator-activated receptor alphaProliferator-activated receptor alphaDysbiotic gut microbiotaLiver macrovesicular steatosisFatty liver diseaseNormal chow dietWeight loss programC57BL/6J male miceNormal hepatic physiologyObese human donorsLiver diseaseChow dietLoss programMice fedHuman gut microbiotaMacrovesicular steatosisMetabolic deterioration