2021
Effect of Mahuang Fuzi and Shenzhuo Decoction on Idiopathic Membranous Nephropathy: A Multicenter, Nonrandomized, Single-Arm Clinical Trial
Dong Z, Dai H, Gao Y, Jiang H, Liu M, Liu F, Liu W, Feng Z, Zhang X, Ren A, Li X, Rui H, Tian X, Li G, Liu B. Effect of Mahuang Fuzi and Shenzhuo Decoction on Idiopathic Membranous Nephropathy: A Multicenter, Nonrandomized, Single-Arm Clinical Trial. Frontiers In Pharmacology 2021, 12: 724744. PMID: 34733157, PMCID: PMC8558382, DOI: 10.3389/fphar.2021.724744.Peer-Reviewed Original ResearchIdiopathic membranous nephropathySingle-arm clinical trialMahuang-FuziMembranous nephropathyCourse of treatmentRemission rateImmunosuppressive therapyDisease remissionUrine proteinClinical trialsSevere adverse eventsCases of patientsMean followAdverse eventsRenal functionClinical effectsNephropathyPatientsBlood albuminRemissionTherapyDecoctionMulticenterObjective performance criteriaTreatment
2020
Alleviation by Mahuang Fuzi and Shenzhuo Decoction in High Glucose‐Induced Podocyte Injury by Inhibiting the Activation of Wnt/β‐Catenin Signaling Pathway, Resulting in Activation of Podocyte Autophagy
Dai H, Liu F, Qiu X, Liu W, Dong Z, Jia Y, Feng Z, Liu Z, Zhao Q, Gao Y, Zhang Z, Gao C, Sun S, Tian X, Liu B. Alleviation by Mahuang Fuzi and Shenzhuo Decoction in High Glucose‐Induced Podocyte Injury by Inhibiting the Activation of Wnt/β‐Catenin Signaling Pathway, Resulting in Activation of Podocyte Autophagy. Evidence-based Complementary And Alternative Medicine 2020, 2020: 7809427. PMID: 32963573, PMCID: PMC7486640, DOI: 10.1155/2020/7809427.Peer-Reviewed Original ResearchDiabetic kidney diseaseHigh glucose-induced podocytesMahuang-FuziPodocyte injuryExcessive activationProtein expressionTreatment of DKDHigh glucoseTraditional Chinese medicine compoundWnt/β-Catenin Signaling PathwayInjury-related proteinsChinese medicine compoundΒ-Catenin Signaling PathwayPathway-related proteinsHigh glucose stimulationInhibition of autophagyKidney diseaseVariety of diseasesPodocyte autophagyFuzi decoctionOrgan fibrosisMetabolic diseasesGolden ChamberInhibitor DKK1Western blotting